Patents by Inventor James B. Thomas

James B. Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12281558
    Abstract: Methods of stimulating a hydrocarbon well are disclosed herein. The hydrocarbon well includes a wellbore that extends within a subterranean formation and a tubular that extends within the wellbore and defines a tubular conduit. The methods include retaining a sealing structure within the tubular conduit and, during the retaining, stimulating a zone of the subterranean formation. Subsequent to the stimulating, the methods include fluidly isolating the zone of the subterranean formation from the uphole region by at least partially sealing the plurality of perforations. Subsequent to the fluidly isolating, the methods include moving the sealing structure in a downhole direction within the tubular conduit. The methods also include repeating the retaining, the stimulating, the fluidly isolating, and the moving a plurality of times to stimulate a plurality of corresponding zones of the subterranean formation.
    Type: Grant
    Filed: November 3, 2023
    Date of Patent: April 22, 2025
    Assignee: ExxonMobil Technology and Engineering Company
    Inventors: James B. Thomas, Owen J. Hehmeyer, Nancy H. Choi, Erik N. English, Eric R. Grueschow
  • Patent number: 11852002
    Abstract: Methods of stimulating a hydrocarbon well are disclosed herein. The hydrocarbon well includes a wellbore that extends within a subterranean formation and a tubular that extends within the wellbore and defines a tubular conduit. The methods include retaining a sealing structure within the tubular conduit and, during the retaining, stimulating a zone of the subterranean formation. Subsequent to the stimulating, the methods include fluidly isolating the zone of the subterranean formation from the uphole region by at least partially sealing the plurality of perforations. Subsequent to the fluidly isolating, the methods include moving the sealing structure in a downhole direction within the tubular conduit. The methods also include repeating the retaining, the stimulating, the fluidly isolating, and the moving a plurality of times to stimulate a plurality of corresponding zones of the subterranean formation.
    Type: Grant
    Filed: September 22, 2022
    Date of Patent: December 26, 2023
    Assignee: ExxonMobil Technology and Engineering Company
    Inventors: James B. Thomas, Owen J. Hehmeyer, Nancy H. Choi, Erik N. English, Eric R. Grueschow
  • Patent number: 11512572
    Abstract: Methods of stimulating a hydrocarbon well are disclosed herein. The hydrocarbon well includes a wellbore that extends within a subterranean formation and a tubular that extends within the wellbore and defines a tubular conduit. The methods include retaining a sealing structure within the tubular conduit and, during the retaining, stimulating a zone of the subterranean formation. Subsequent to the stimulating, the methods include fluidly isolating the zone of the subterranean formation from the uphole region by at least partially sealing the plurality of perforations. Subsequent to the fluidly isolating, the methods include moving the sealing structure in a downhole direction within the tubular conduit. The methods also include repeating the retaining, the stimulating, the fluidly isolating, and the moving a plurality of times to stimulate a plurality of corresponding zones of the subterranean formation.
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: November 29, 2022
    Assignee: ExxonMobil Upstream Research Company
    Inventors: James B. Thomas, Owen J. Hehmeyer, Nancy H. Choi, Erik N. English, Eric R. Grueschow
  • Patent number: 11292783
    Abstract: Potent opioid receptor antagonists of formula (I) and their use as pharmacotherapies for treating depression, anxiety, schizophrenia, eating disorders, and addiction to cocaine, methamphetamine, nicotine, alcohol, and opiates are disclosed. More specifically, the disclosure provides potent and selective kappa opioid receptor antagonist compounds, pharmaceutical compositions of those compounds and uses of those compounds to ameliorate or treat addictions, eating disorders, etc.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: April 5, 2022
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Chad M. Kormos, Pauline W. Ondachi, Scott P. Runyon, Hernan A. Navarro, James B. Thomas, S. Wayne Mascarella
  • Publication number: 20190263781
    Abstract: Potent opioid receptor antagonists of formula (I) and their use as pharmacotherapies for treating depression, anxiety, schizophrenia, eating disorders, and addiction to cocaine, methamphetamine, nicotine, alcohol, and opiates are disclosed. More specifically, the disclosure provides potent and selective kappa opioid receptor antagonist compounds, pharmaceutical compositions of those compounds and uses of those compounds to ameliorate or treat addictions, eating disorders, etc.
    Type: Application
    Filed: September 15, 2017
    Publication date: August 29, 2019
    Applicant: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Chad M. Kormos, Pauline W. Ondachi, Scott P. Runyon, Hernan A. Navarro, James B. Thomas, S. Wayne Mascarella
  • Patent number: 9750738
    Abstract: Provided are opioid receptor antagonists represented by the formula (I): where R, Y3, R1, R2, R3, R4 and R5 are as defined herein.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: September 5, 2017
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Frank Ivy Carroll, Juan P. Cueva, James B. Thomas, S. Wayne Mascarella, Scott P. Runyon
  • Patent number: 9512105
    Abstract: Provided are compounds represented by the formula: where R, Y3, R1, R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: December 6, 2016
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Frank I. Carroll, James B. Thomas, Hernan A. Navarro, S. Wayne Mascarella, Scott P. Runyon, Chunyang Jin, Chad M. Kormos
  • Patent number: 9273027
    Abstract: Provided are opioid receptor antagonists represented by the formula (I) where R, Y3, R1, R2, R3, R4 and R5 are as defined herein.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: March 1, 2016
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Frank I. Carroll, Juan P. Cueva, James B. Thomas, S. Wayne Mascarella, Scott P. Runyon
  • Patent number: 8968373
    Abstract: An implantable screw system for maintaining horizontal and/or vertical space during bone grafting procedures is provided, the screw comprising: a contoured head having a region adapted to support soft tissue and permit bone growth; a threaded shaft and a tip adapted to penetrate bone tissue; and where one screw contains a threaded chamber for engaging a second screw for additional space maintenance; wherein the screw(s) comprises cortical bone material. Methods of implanting one or more screws during bone grating procedures are disclosed.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: March 3, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Jonathan M. Brunger, Jeffrey M. Badura, James B. Thomas
  • Publication number: 20150005315
    Abstract: Provided are compounds represented by the formula: where R, Y3, R1, R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.
    Type: Application
    Filed: December 10, 2012
    Publication date: January 1, 2015
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: Frank I. Carroll, James B. Thomas, Hernan A. Navarro, S. Wayne Mascarella, Scott P. Runyon, Chunyang Jin, Chad M. Kormos
  • Publication number: 20130158072
    Abstract: Kappa opioid recep-tor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor, such as heroin or cocaine addictions.
    Type: Application
    Filed: January 19, 2010
    Publication date: June 20, 2013
    Applicant: Research Triangle Institute
    Inventors: Frank Ivy Carroll, James B. Thomas, S. Wayne Mascarella
  • Publication number: 20120295919
    Abstract: Provided are opioid receptor antagonists represented by the formula (I) where R, Y3, R1, R2, R3, R4 and R5 are as defined herein.
    Type: Application
    Filed: October 12, 2010
    Publication date: November 22, 2012
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: Frank I. Carroll, Juan P. Cueva, James B. Thomas, S. Wayne Mascarella, Scott P. Runyon
  • Publication number: 20120178781
    Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
    Type: Application
    Filed: February 29, 2012
    Publication date: July 12, 2012
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: Frank Ivy CARROLL, Hernan A. Navarro, Lawrence E. Brieaddy, Scott P. Runyon, James B. Thomas
  • Patent number: 8173678
    Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: May 8, 2012
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Hernan A. Navarro, Lawrence E. Brieaddy, Scott P. Runyon, James B. Thomas
  • Patent number: 8048895
    Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: November 1, 2011
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Hernan A. Navarro, James B. Thomas, Tingwei Cai
  • Publication number: 20110065743
    Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
    Type: Application
    Filed: October 25, 2010
    Publication date: March 17, 2011
    Applicant: Research Triangle Institute
    Inventors: Frank Ivy CARROLL, Hernan A. Navarro, Lawrence E. Brieaddy, Scott P. Runyon, James B. Thomas
  • Patent number: 7872023
    Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: January 18, 2011
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Hernan A. Navarro, Lawrence E. Brieaddy, Scott P. Runyon, James B. Thomas
  • Publication number: 20100190746
    Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.
    Type: Application
    Filed: November 20, 2009
    Publication date: July 29, 2010
    Applicant: ICAGEN, INC.
    Inventors: Grant A. McNaughton-Smith, James B. Thomas, JR., George S. Amato
  • Publication number: 20100023064
    Abstract: An implantable screw system for maintaining horizontal and/or vertical space during bone grafting procedures is provided, the screw comprising: a contoured head having a region adapted to support soft tissue and permit bone growth; a threaded shaft and a tip adapted to penetrate bone tissue; and where one screw contains a threaded chamber for engaging a second screw for additional space maintenance; wherein the screw(s) comprises cortical bone material. Methods of implanting one or more screws during bone grating procedures are disclosed.
    Type: Application
    Filed: July 24, 2008
    Publication date: January 28, 2010
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Jonathan M. BRUNGER, Jeffrey M. Badura, James B. Thomas
  • Publication number: 20090264462
    Abstract: Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
    Type: Application
    Filed: April 18, 2008
    Publication date: October 22, 2009
    Applicant: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Hernan A. Navarro, James B. Thomas, Tingwei Cai