Patents by Inventor James B. Trager

James B. Trager has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene expression markers for predicting overall survival in subjects treated with sipuleucel-T
    Patent number: 11970743
    Abstract: Gene expression profiling in patients with mCRPC identifying genes that predict overall survival in response to treatment with sipuleucel-T, the method comprising the steps of (a) determining a gene expression level of a first biomarker; (b) determining a gene expression level of at least one additional biomarker different from the first biomarker; and (c) transforming the expression level of the first biomarker and the at least one additional biomarker into a first score corresponding to a probability of overall survival in response to treatment with sipuleucel-T.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: April 30, 2024
    Assignee: Dendreon Pharmaceuticals LLC
    Inventors: James B. Trager, Nadeem A. Sheikh, Debraj GuhaThakurta, Harini Kandadi, Li-Qun Fan
  • METHODS FOR THE SIMULTANEOUS EXPANSION OF MULTIPLE IMMUNE CELL TYPES, RELATED COMPOSITIONS AND USES OF SAME IN CANCER IMMUNOTHERAPY
    Publication number: 20220047635
    Abstract: Several embodiments disclosed herein relate to methods and processes for the co-expansion of multiple types of immune cells, in order to generate a mixed cell population. Some embodiments relate to the use of various stimuli specific to the various subpopulations to achieve expansion of those subpopulations at a particular time in a culturing process in order to generate an expanded population of immune cells having a desired ratio of the various subpopulations. In several embodiments, such mixed cell populations exhibit desirable characteristics, such as cytotoxic effects against tumor cells that enhance the efficacy of cancer immunotherapy.
    Type: Application
    Filed: November 22, 2019
    Publication date: February 17, 2022
    Inventors: Daofeng LIU, Guangnan LI, James B. TRAGER
  • GENE EXPRESSION MARKERS FOR PREDICTING OVERALL SURVIVAL IN SUBJECTS TREATED WITH SIPULEUCEL-T
    Publication number: 20200017921
    Abstract: Gene expression profiling in patients with mCRPC identifying genes that predict overall survival in response to treatment with sipuleucel-T, the method comprising the steps of (a) determining a gene expression level of a first biomarker; (b) determining a gene expression level of at least one additional biomarker different from the first biomarker; and (c) transforming the expression level of the first biomarker and the at least one additional biomarker into a first score corresponding to a probability of overall survival in response to treatment with sipuleucel-T.
    Type: Application
    Filed: September 9, 2019
    Publication date: January 16, 2020
    Inventors: James B. Trager, Nadeem A. Sheikh, Debraj GuhaThakurta, Harini Kandadi, Li-Qun Fan
  • GENE EXPRESSION MARKERS FOR PREDICTING OVERALL SURVIVAL IN SUBJECTS TREATED WITH SIPULEUCEL-T
    Publication number: 20170107580
    Abstract: Gene expression profiling in patients with mCRPC identifying genes that predict overall survival in response to treatment with sipuleucel-T, the method comprising the steps of (a) determining a gene expression level of a first biomarker; (b) determining a gene expression level of at least one additional biomarker different from the first biomarker; and (c) transforming the expression level of the first biomarker and the at least one additional biomarker into a first score corresponding to a probability of overall survival in response to treatment with sipuleucel-T.
    Type: Application
    Filed: September 16, 2016
    Publication date: April 20, 2017
    Inventors: James B. Trager, Nadeem A. Sheikh, Debraj GuhaThakurta, Harini Kandadi, Li-Qun Fan