Abstract: An antiseptic solution including, a cationic antiseptic agent, a film forming polymer, an anionic tinting agent, and a solvent, wherein the cationic antiseptic agent, the film forming polymer and the anionic tinting agent each remain solubilized within the solution for greater than about 1 hour at 25° C. and 60% relative humidity. The antiseptic agent is preferably octenidine dihydrochloride or chlorhexadine gluconate. The film forming polymer is preferably an acrylate polymer. The solvent is preferably ethanol, isopropanol, and n-propanol. When a drape is adhered to a dried surgical film via the antiseptic solution, the force required to peel the drape from the surgical film is at least about 105 g/25 mm.

Abstract: Copper salts of ion exchange materials provide copper ions at levels suitable for use as an anti-infective agent. The copper salts of ion exchange materials may be formed using ether and ester derivatives of cellulose, such as carboxymethyl cellulose (CMC), ethylcellulose (EC), methylcellulose (MC), hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), hydroxyethyl methyl cellulose (HEMC), cellulose acetate, and cellulose triacetate. Wound dressings having copper salts of ion exchange materials incorporated therein are also provided, and may be used to reduce the incidence of infection in wounds. The wound dressings may also be used to prevent infections in long-term wounds, such as those formed at wound drain, catheter, and ostomy entry sites. Copper salts of ion exchange materials may be used to kill microorganisms, and may optionally be used with additional anti-infective agents.

Abstract: The present invention relates to methods and compositions for enhancing folding and stability of biological molecules. In particular, the present invention relates to methods and compositions for identifying biological molecules with enhanced stability. The present invention further relates to host cells that confer enhanced stability to biological molecules expressed therein.

Abstract: An antiseptic solution including, a cationic antiseptic agent, a film forming polymer, an anionic tinting agent, and a solvent, wherein the cationic antiseptic agent, the film forming polymer and the anionic tinting agent each remain solubilized within the solution for greater than about 1 hour at 25° C. and 60% relative humidity. The antiseptic agent is preferably octenidine dihydrochloride or chlorhexadine gluconate. The film forming polymer is preferably an acrylate polymer. The solvent is preferably ethanol, isopropanol, and n-propanol. When a drape is adhered to a dried surgical film via the antiseptic solution, the force required to peel the drape from the surgical film is at least about 105 g/25 mm.

Abstract: An applicator having a hydrophobic foam that is suitable for use with antiseptic solutions may be a hydrophobic polyurethane foam that does not reduce the amount of active ingredient in the solution as it passes through the foam so that it can be applied to the skin. The foam may be used to deliver antiseptics solutions such as octenidine salts, chlorhexidine salts, or any cationic molecule to the skin. The solution may include alcohol solution. The foam may be attached to an applicator containing an antiseptic solution, or it may be used in conjunction with an unattached antiseptic solution reservoir. The foam also allows the solution to wick into the foam and fully saturate the foam without dripping or channeling.

Abstract: An applicator having a hydrophilic foam that is suitable for use with antiseptic solutions may be a hydrophilic polyurethane foam that does not reduce the amount of active ingredient in the solution as it passes through the foam so that it can be applied to the skin. The foam may be used to deliver antiseptics solutions such as octenidine salts, chlorhexidine salts, or any cationic molecule to the skin. The foam may be attached to an applicator containing an antiseptic solution, or it may be used in conjunction with an unattached antiseptic solution reservoir. The foam also allows the solution to wick into the foam and fully saturate the foam without dripping or channeling.

Abstract: Copper salts of ion exchange materials provide copper ions at levels suitable for use as an anti-infective agent. The copper salts of ion exchange materials may be formed using ether and ester derivatives of cellulose, such as carboxymethyl cellulose (CMC), ethylcellulose (EC), methylcellulose (MC), hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), hydroxyethyl methyl cellulose (HEMC), cellulose acetate, and cellulose triacetate. Wound dressings having copper salts of ion exchange materials incorporated therein are also provided, and may be used to reduce the incidence of infection in wounds. The wound dressings may also be used to prevent infections in long-term wounds, such as those formed at wound drain, catheter, and ostomy entry sites. Copper salts of ion exchange materials may be used to kill microorganisms, and may optionally be used with additional anti-infective agents.

Abstract: The present invention relates generally to particles that include one or more antimicrobial agents therein and/or thereon. The particles may be provided with one or more coatings that contain one or more antimicrobial agents, or the one or more antimicrobial agents may be embedded in the particles. The present invention also relates to goods such as medical devices, personal care products, and household devices that incorporate one or more antimicrobial particles. The goods may be provided with one or more coatings that contain the antimicrobial particles, or the antimicrobial particles may be physically embedded in the medical devices. The present invention is further directed towards methods of making such medical devices. The goods incorporating the antimicrobial particles may be used in accordance with methods of killing microorganisms and preventing infections.

Abstract: The present invention relates to methods and compositions for enhancing folding and stability of biological molecules. In particular, the present invention relates to methods and compositions for identifying biological molecules with enhanced stability. The present invention further relates to host cells that confer enhanced stability to biological molecules expressed therein.

Abstract: Aqueous antiseptic solutions and compatible dyes and methods for making and using such solutions are provided. Specifically, in one embodiment, the present invention relates to an antiseptic solution comprising a micellular complex consisting of a cationic excipient and an anionic dye. The antiseptic solution further includes a cationic antiseptic.

Abstract: Aqueous antiseptic solutions and compatible dyes and methods for making and using such solutions are provided. More specifically, in one embodiment, the present invention relates to an aqueous antiseptic solution comprising an aqueous solution of chlorhexidine or a salt thereof, an anionic dye in an amount sufficient to stain a patient's skin when the aqueous solution is applied thereon, and a cationic excipient.

Abstract: Aqueous antiseptic solutions and compatible dyes for staining skin and methods for making and using such solutions are provided. More specifically, in one embodiment, the present invention relates to an aqueous antiseptic solution comprising an aqueous solution of chlorhexidine or a salt thereof and a cationic dye in an amount sufficient to stain a patient's skin when the aqueous solution is applied thereon.

Abstract: The present invention relates generally to applicators and a method for reducing the concentration of unwanted chemicals, such as para-chloroaniline (PCA) from an antiseptic solution. More specifically, the applicator includes antiseptic solution in amount sufficient to be applied to a desired surface and to have an antimicrobial effect on the desired surface and a porous element. The porous element selectively removes undesired by-products from the antiseptic solution when the antiseptic solution contacts the at least one porous element.

Abstract: A device, and method for making same, for insertion into a hollow organ of an animal, including humans is disclosed. The device includes a first tubular member having a first diameter, a proximal portion, and a distal portion formed to include a first aperture. The device further includes a tubular access assembly comprising a proximal portion having a second diameter and formed to include a second aperture, and a distal portion having said the diameter, where that distal portion of the access assembly is continuously attached to the proximal portion of the first tubular member, and where the second diameter is greater than or equal to the first diameter. The device further includes an inflatable internal retention assembly disposed around the distal portion of the first tubular member, where that inflatable retention assembly comprises a fluorinated siloxane elastomer.