Abstract: Novel phosphotetrahydropyran compounds that mimic mannose-6-phosphate but that are more resistant to phosphatases and mannosidases, and pharmaceutical compositions thereof, are disclosed. These compounds and compositions inhibit T lymphocyte migration from blood to tissues or to other extravascular sites. By inhibiting such migration, these compounds are useful for treating diseases or disorders that are mediated at least in part by such T lymphocyte migration. Such diseases and disorders include rheumatoid arthritis, multiple sclerosis, acute disseminated encephalomyelitis, psoriasis, inflammatory bowel disease, T cell-mediated dermatitis, stromal keratitis, uveitis, thyroiditis, sialitis and type I diabetes.

Abstract: A light detector having spaced electrodes preset by pins or a spacer within a sealed enclosure. The detector may have a MEMS structure that is separate from the sealing of the enclosure. Further, the detector may have a lens for the transmission of light onto the elements. The lens may be coated to affect the amount of light admitted into the enclosure. Light detectable by the sensor may be ultra-violet.

Abstract: Systems and methods for trading property loss or damage on a futures-based exchange. A system can include receiving information related to one or more futures-based contracts. A transaction is generated with respect to the one or more futures-based contracts. The futures-based exchange is used as a clearing house with respect to the generated transaction.

Abstract: A step-down power transfer device for providing a dropped drive line in a front engine and rear drive vehicle. The step-down power transfer device is preferably chain or gear driven. A preferred vehicle a includes a power train having a longitudinally mounted front engine, a step-down power transfer device, a single segment drive shaft, a half-shaft differential, swing axles and geared reduction wheel end drives. The vehicle can have an exceptionally low, i.e., 16 to 18 inches, load floor that is flat at least between the step-down power transfer device and the differential. The resultant vehicle has many parts in common with popular traditional front engine/rear drive trucks. Combining the power train described above with a low profile rear suspension provides added low load floor benefits.

Abstract: A light detector having spaced electrodes preset by pins or a spacer within a sealed enclosure. The detector may have a MEMS structure that is separate from the sealing of the enclosure. Further, the detector may have a lens for the transmission of light onto the elements. The lens may be coated to affect the amount of light admitted into the enclosure. Light detectable by the sensor may be ultra-violet.

Abstract: The present invention provides phosphotetrahydropyran compounds and the use thereof in treating diseases or conditions that are dependent on T-lymphocyte migration, as well as compositions containing said compounds.

Abstract: The present invention provides phosphotetrahydropyran compounds and the use thereof in treating diseases or conditions that are dependent on T-lymphocyte migration, as well as compositions containing said compounds.

Abstract: A device for moving a rock lodged in a rock crusher which includes a support on which is mounted a first turntable. Connected to and extending from the first turntable is a second turntable the rotational axis of which is offset from the rotational axis of the first turntable. Also provided is a boom pivotally connected to the second turntable. The boom includes an extendable boom member slidably mounted in the main boom portion and on the end thereof a pivotal hook together with means for operating the turntables, boom and hook individually or in combination to place the hook adjacent a rock in a crusher and then move the rock to a position whereby the crusher can accept and crush it.