Abstract: A system for moving an elongate tool through a lumen can include a proximal device and a distal device. The proximal device moves linearly in proximal and distal directions and includes a proximal shutter that between an open state in which an elongate tool moves freely through the proximal shutter and a closed state in which the elongate tool is fixedly held by the proximal shutter. The distal device moves linearly in the proximal and distal directions and includes a distal shutter that transitions between an open state in which the elongate tool moves freely through the distal shutter and a closed state in which the elongate tool is fixedly held by the distal shutter. The motions of the proximal and distal devices can be coordinate to provide smooth, continuous, and/or uninterrupted insertion or retraction of the elongate tool.

Abstract: A system for moving a catheter over a parked elongate tool through a lumen can include a catheter device, a proximal elongate tool device, and a distal elongate tool device. The catheter device can be engaged with the catheter device. An elongate device can be inserted through the lumen of the catheter and through the proximal elongate tool device and the distal elongate tool device. The catheter device can be configured to move proximally and distally to insert or retract the catheter. The proximal and distal elongate tool devices can be configured to walk proximally and distally along the parked elongate tool to maintain a desired spatial relationship between the catheter device and proximal and distal elongate tool devices.

Abstract: System for guiding an instrument within a vascular network of a patient are disclosed. In some embodiments, the system receives a medical image from a medical imaging device and identifies a distal tip and a direction the instrument in the image. The system may then determine a waypoint for the distal tip of the instrument based at least in part on the position and direction of the distal tip of the instrument. The system may then generate a trajectory command for moving the instrument through the vascular network from the current position to the waypoint. The system may operate in a closed loop. The system may provide the trajectory command to a robotic medical system configured to move the instrument according to the command.

Abstract: In a general aspect, the friction of a fracture treatment fluid is monitored during a hydraulic fracture treatment. In some aspects, a system includes a conduit that communicates a facture treatment fluid from a pump system toward a well system during a hydraulic fracture treatment. The conduit includes interior and exterior surfaces. A first channel extends from a first interior port defined by the interior surface to a first exterior port defined by the exterior surface. A second channel extends from a second interior port defined by the interior surface to a second exterior port defined by the exterior surface. The system includes a differential pressure sensor that measures a pressure difference between the first and second exterior ports of the conduit during the hydraulic fracture treatment. The system includes a control unit that determines a friction of the fracture treatment fluid based on the pressure difference and the distance.

Abstract: In a general aspect, a submersible barge includes a deck having a support surface and an additive manufacturing system. The submersible barge may be deployed on a body of water. The additive manufacturing system is configured to fabricate a cementitious body on the support surface by successively depositing layers of flowable cementitious material on top of each other. The submersible barge also includes a buoyancy system that is configured to lower the cementitious body into the body of water by altering a draft of the submersible barge between first and second drafts. When the submersible barge is at the first draft, the support surface resides above a surface of the body of water. When the submersible barge is at the second draft, the support surface resides below the surface of the body of water.

Abstract: A data pipeline validation system and method configured to partially automate testing of data pipelines in a distributed computing environment. The system includes a data pipeline analytic device equipped with various modules, such as a query generation module, data frame comparison module, and metadata management module. The query generation module employs natural language processing techniques to analyze configuration entries and dynamically generate SQL queries tailored to specific test cases. The data frame comparison module compares the results of different test cases using distributed collections, enabling parallel processing and efficient result comparison. The metadata management module captures and stores relevant metadata for traceability and auditing purposes. The system facilitates comprehensive validation of data pipelines, enabling organizations to ensure the accuracy, reliability, and integrity of data.

Abstract: Systems and methods for vision-based position and orientation determination for endovascular tools are disclosed. In one example, a method includes receiving a two-dimensional medical image including a view of at least a distal portion of a medical instrument, the distal portion of the medical instrument including one or more fiducials positioned thereon, the one or more fiducials being radio-opaque and visible in the medical image. The method also includes detecting, within the medical image, a two-dimensional appearance of the one or more fiducials, and based on the two-dimensional appearance of the one or more fiducials, determining at least one of a roll angle of the distal portion of the medical instrument, and an incline of the distal portion of the medical instrument.

Abstract: A steerable catheter system is disclosed. The system includes a steerable catheter including a handle and a steerable elongated body. The handle includes user inputs for image space control commands for articulating the elongated body with respect to a plane of a medical image. The elongated body includes pose determination features that allow determination of a roll angle of the elongated body. The system also includes a control unit that receives the image space control commands, determines the roll angle of the elongated body based on the pose determination features, translates the image space control commands into pullwire commands based on the roll angle, and transmits the pullwire commands to the steerable catheter, whereby the elongated body is articulated according to the pullwire commands.

Abstract: A system for moving a catheter over a parked elongate tool through a lumen can include a catheter device, a proximal elongate tool device, and a distal elongate tool device. The catheter device can be engaged with the catheter device. An elongate device can be inserted through the lumen of the catheter and through the proximal elongate tool device and the distal elongate tool device. The catheter device can be configured to move proximally and distally to insert or retract the catheter. The proximal and distal elongate tool devices can be configured to walk proximally and distally along the parked elongate tool to maintain a desired spatial relationship between the catheter device and proximal and distal elongate tool devices.

Abstract: A system for moving an elongate tool through a lumen can include a proximal device and a distal device. The proximal device moves linearly in proximal and distal directions and includes a proximal shutter that between an open state in which an elongate tool moves freely through the proximal shutter and a closed state in which the elongate tool is fixedly held by the proximal shutter. The distal device moves linearly in the proximal and distal directions and includes a distal shutter that transitions between an open state in which the elongate tool moves freely through the distal shutter and a closed state in which the elongate tool is fixedly held by the distal shutter. The motions of the proximal and distal devices can be coordinate to provide smooth, continuous, and/or uninterrupted insertion or retraction of the elongate tool.

Abstract: A steerable catheter system is disclosed. The system includes a steerable catheter including a handle and a steerable elongated body. The handle includes user inputs for image space control commands for articulating the elongated body with respect to a plane of a medical image. The elongated body includes pose determination features that allow determination of a roll angle of the elongated body. The system also includes a control unit that receives the image space control commands, determines the roll angle of the elongated body based on the pose determination features, translates the image space control commands into pullwire commands based on the roll angle, and transmits the pullwire commands to the steerable catheter, whereby the elongated body is articulated according to the pullwire commands.

Abstract: A steerable catheter system is disclosed. The system includes a steerable catheter including a handle and a steerable elongated body. The handle includes user inputs for image space control commands for articulating the elongated body with respect to a plane of a medical image. The elongated body includes pose determination features that allow determination of a roll angle of the elongated body. The system also includes a control unit that receives the image space control commands, determines the roll angle of the elongated body based on the pose determination features, translates the image space control commands into pullwire commands based on the roll angle, and transmits the pullwire commands to the steerable catheter, whereby the elongated body is articulated according to the pullwire commands.

Abstract: A data pipeline validation system and method configured to partially automate testing of data pipelines in a distributed computing environment. The system includes a data pipeline analytic device equipped with various modules, such as a query generation module, data frame comparison module, and metadata management module. The query generation module employs natural language processing techniques to analyze configuration entries and dynamically generate SQL queries tailored to specific test cases. The data frame comparison module compares the results of different test cases using distributed collections, enabling parallel processing and efficient result comparison. The metadata management module captures and stores relevant metadata for traceability and auditing purposes. The system facilitates comprehensive validation of data pipelines, enabling organizations to ensure the accuracy, reliability, and integrity of data.

Abstract: System for guiding an instrument within a vascular network of a patient are disclosed. In some embodiments, the system receives a medical image from a medical imaging device and identifies a distal tip and a direction the instrument in the image. The system may then determine a waypoint for the distal tip of the instrument based at least in part on the position and direction of the distal tip of the instrument. The system may then generate a trajectory command for moving the instrument through the vascular network from the current position to the waypoint. The system may operate in a closed loop. The system may provide the trajectory command to a robotic medical system configured to move the instrument according to the command.

Abstract: A system for advancing a guidewire through a patient lumen including a first advancement device and a second advancement device. The second advancement device may be positioned between the first advancement device and an access point to the patient lumen. The first advancement device may close to contact the guidewire and open to not contact the wire. When the first advancement device is closed the first advancement device may move from a first position to a second position to advance the guidewire through the patient lumen. The first advancement device may rotate to rotate the guidewire. The second advancement device may be coupled to a microcatheter.

Abstract: Systems and methods for vision-based position and orientation determination for endovascular tools are disclosed. In one example, a method includes receiving a two-dimensional medical image including a view of at least a distal portion of a medical instrument, the distal portion of the medical instrument including one or more fiducials positioned thereon, the one or more fiducials being radio-opaque and visible in the medical image. The method also includes detecting, within the medical image, a two-dimensional appearance of the one or more fiducials, and based on the two-dimensional appearance of the one or more fiducials, determining at least one of a roll angle of the distal portion of the medical instrument, and an incline of the distal portion of the medical instrument.

Abstract: Techniques for assessing a computing risk of an entity based on a social media footprint of that user. Social media accounts of an entity are identified. Queries are executed against the accounts to determine a social media footprint the entity has based on engagements with those accounts. The footprint reflects at least how much information associated with the entity has been exposed as a result of the engagements with those accounts. Based on the footprint, a risk score for the entity is developed. The risk score reflects a determined amount of computing risk the entity has with regard to potential malicious use of exposed entity information. Based on the risk score, mitigation operations are performed in an attempt to reduce the risk score.

Abstract: A computer-implemented method for indicating the possibility of a cyber-attack on a computer network, comprising: receiving, from one or more security components installed in a network, an indication of activity within the network associated with a security threat; mapping the indication of activity to one or more cyber-attack techniques; identifying one or more previously received indications of activity within the network associated with a security threat; identifying one or more cyber-attack techniques to which the previously received indication(s) of activity have been mapped; determining whether the indication of activity is associated with one or more of the previously received indication(s) of activity, the determination based at least in part on a strength of a relationship between the one or more cyber-attack techniques to which the indication of activity is mapped and the one or more cyber-attack techniques to which the previously received indication(s) of activity have been mapped; and dependent on

Abstract: The present disclosure relates generally to encapsulated strict obligate anaerobic bacteria, (e.g., Megasphaera eldesdenii and Ruminicoccus bromi), compositions comprising same, and the use of said capsules and/or compositions to deliver the strict obligate anaerobic bacteria to the gastrointestinal tract (GI) of an animal, such as a livestock animal (e.g., a ruminant or hindgut fermenter). The present disclosure relates to the encapsulation of strict obligate anaerobic bacteria which utilize lactic acid and/or starch and the use of those encapsulated bacteria in the field of animal health and nutrition. In particular examples, the present disclosure utilises porous capsules comprising surface pores with a molecular weight cut off between 50 and 200 kDa and wall comprising a complex formed from sodium cellulose sulphate and poly [dimethyldially-ammonium chloride].

Abstract: A computer-implemented method for indicating the possibility of a cyber-attack on a computer network, comprising: receiving, from one or more security components installed in a network, an indication of activity within the network associated with a security threat; mapping the indication of activity to one or more cyber-attack techniques; identifying one or more previously received indications of activity within the network associated with a security threat; identifying one or more cyber-attack techniques to which the previously received indication(s) of activity have been mapped; determining whether the indication of activity is associated with one or more of the previously received indication(s) of activity, the determination based at least in part on a strength of a relationship between the one or more cyber-attack techniques to which the indication of activity is mapped and the one or more cyber-attack techniques to which the previously received indication(s) of activity have been mapped; and dependent on