Abstract: A wide variety of scenarios are supported for per-biosample aggregation of sequencing yield. A sequencing system can sequence a plurality of biosamples in parallel. As sequencing yield results are acquired, they can be matched to biosamples and sequencing progress for the biosamples can be monitored. A target amount of yield can be specified so that a sequencing yield analysis application is automatically launched when aggregated yield reaches the target. Other features related to quality control and yield-in-progress can result in more efficient sequencing activities and reduction in waste.

Abstract: The invention relates methods of improving signal detection from an array and methods for background subtraction in an array. The invention provides for novel array compositions including arrays with wells with different shapes, or surfaces coated with reflective or selectively absorptive coatings. In addition, the array include a signal transducer element.