Abstract: A method is provided for manufacturing an aqueous formulation of a manganese-containing coordination complex, by combining a source of the manganese-containing coordination complex with a source of chloride anion in an aqueous solution, and simultaneously with or following combination of the source of chloride anion and the source of manganese-containing coordination complex in the aqueous solution, providing a source of a dianion to the aqueous solution to form the aqueous formulation.

Abstract: The present invention provides compositions for the treatment of cancer. The compositions include liposomes containing a phosphatidylcholine lipid, a sterol, a PEG-lipid, and a taxane. The PEG-lipid constitutes from about 2 to about 8 mol % of the lipids in the liposome. The taxane is docetaxel esterified at the 2?-O position with a heterocyclyl-(C2-5 alkanoic acid). The present invention also provides liposomal compositions for the treatment of cancer comprising administering to a patient in need thereof a liposome, wherein the liposome comprises: a phosphatidylcholine lipid; a sterol; a PEG-lipid; and a taxane or a pharmaceutically acceptable salt thereof; wherein the taxane is docetaxel esterified at the 2?-O-position with a heterocyclyl-(C2-5alkanoic acid); and wherein upon administration of the liposomal composition to the patient, the plasma concentration of docetaxel remain above an efficacy threshold of 0.2 ?M for at least 5 hours.

Abstract: The present invention provides compositions for the treatment of cancer. The compositions include liposomes containing a phosphatidylcholine lipid, a sterol, a PEG-lipid, and a taxane. The PEG-lipid constitutes from about 2 to about 8 mol % of the lipids in the liposome. The taxane is docetaxel esterified at the 2?-O position with a heterocyclyl-(C2-5alkanoic acid). Methods for preparation of liposomal taxanes and treatment of cancer with liposomal taxanes are also disclosed.

Abstract: A multi-ply paper web is formed by bringing a top ply liner into ply-bonding engagement with a base ply web (W.sub.B) traveling on a base ply forming wire (36). The top ply liner (W.sub.T) is formed between two co-running forming wires (10, 20) in a convex upwardly/concave downwardly curved, substantially horizontal forming zone. Dewatering in the forming zone is effected by applying sub-atmospheric air pressure solely beneath the lower surface of the top ply liner (W.sub.T) being formed. Water is removed from the upper surface of the top ply liner (W.sub.T) solely by wire tension, gravity and centrifugal force created by passing the co-running forming wires (10, 20) over the convex upwardly curved path of travel. This permits a greater concentration of pulp stock fines to remain in the upper surface of the top ply liner (W.sub.T) to effect greater ply-bonding affinity with the base ply (W.sub.B) when the two plies (W.sub.T, W.sub.B) are brought together and bonded.