Patents by Inventor James Bottomley
James Bottomley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240383949Abstract: Described are mutant human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.Type: ApplicationFiled: February 7, 2024Publication date: November 21, 2024Applicant: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Enrico MALITO, Matthew James BOTTOMLEY, Andrea CARFI, Sumana CHANDRAMOULI, Kate LUISI
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Patent number: 11932669Abstract: Described are mutant human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.Type: GrantFiled: April 6, 2021Date of Patent: March 19, 2024Assignee: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Enrico Malito, Matthew James Bottomley, Andrea Carfi, Sumana Chandramouli, Kate Luisi
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Publication number: 20230303637Abstract: Polypeptides capable of self-assembling into a nanoparticle, and nanoparticles made up of such polypeptides.Type: ApplicationFiled: June 11, 2021Publication date: September 28, 2023Applicant: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Matthew James BOTTOMLEY, Newton Muchugu WAHOME
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Publication number: 20230250142Abstract: Pairs of peptides capable of forming spontaneous covalent bonds, and their uses, such as in forming fusion proteins.Type: ApplicationFiled: June 11, 2021Publication date: August 10, 2023Applicant: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Matthew James BOTTOMLEY, Roberta COZZI, Newton Muchugu WAHOME
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Patent number: 11194639Abstract: Embodiments of the present systems and methods may provide additional security mechanisms inside an operating system kernel itself by executing system calls in a dedicated address space to reduce the amount of shared resources that are visible to and thus exploitable by a malicious application. For example, in an embodiment, a method implemented in a computer may comprise a processor, memory accessible by the processor, and computer program instructions stored in the memory and executable by the processor, the method may comprise: when a user process makes a system call, switching to kernel mode and using a system call page table for the user process to execute a system call handler, when the system call handler attempts to access unmapped kernel space memory, generating a page fault, and handling the page fault by determining whether the attempted access to unmapped kernel space memory is allowed.Type: GrantFiled: May 19, 2019Date of Patent: December 7, 2021Assignee: International Business Machines CorporationInventors: James Bottomley, Joel Kelly Nider, Michael Rapoport
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Publication number: 20210277067Abstract: Described are mutant human cytomegalovirus (HCMV) pentamer complex polypeptides, methods of making them, and their use in HCMV protein complexes and compositions. In particular, the use of the modified HCMV polypeptides to stabilize HCMV complexes or unmask a pentamer epitope is described.Type: ApplicationFiled: April 6, 2021Publication date: September 9, 2021Inventors: Enrico MALITO, Matthew James BOTTOMLEY, Andrea CARFI, Sumana CHANDRAMOULI, Kate LUISI
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Patent number: 11093657Abstract: Embodiments of the present systems and methods may provide additional security mechanisms inside an operating system kernel itself by isolating parts of the kernel to protect them from attacks. For example, in an embodiment, a computer-implemented method implemented in a computer comprising a processor, memory accessible by the processor, and computer program instructions stored in the memory and executable by the processor, the method may comprise: creating a namespace in an operating system kernel-space in the memory of the computer, creating an address space for the namespace that maps only kernel objects owned by the namespace, and providing access to kernel objects owned by the namespace only to the least one user process using the combined page table.Type: GrantFiled: May 19, 2019Date of Patent: August 17, 2021Assignee: International Business Machines CorporationInventors: James Bottomley, Joel Kelly Nider, Michael Rapoport
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Publication number: 20200364375Abstract: Embodiments of the present systems and methods may provide additional security mechanisms inside an operating system kernel itself by isolating parts of the kernel to protect them from attacks. For example, in an embodiment, a computer-implemented method implemented in a computer comprising a processor, memory accessible by the processor, and computer program instructions stored in the memory and executable by the processor, the method may comprise: creating a namespace in an operating system kernel-space in the memory of the computer, creating an address space for the namespace that maps only kernel objects owned by the namespace, and providing access to kernel objects owned by the namespace only to the least one user process using the combined page table.Type: ApplicationFiled: May 19, 2019Publication date: November 19, 2020Inventors: James Bottomley, Joel Kelly Nider, Michael Rapoport
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Publication number: 20200364101Abstract: Embodiments of the present systems and methods may provide additional security mechanisms inside an operating system kernel itself by executing system calls in a dedicated address space to reduce the amount of shared resources that are visible to and thus exploitable by a malicious application. For example, in an embodiment, a method implemented in a computer may comprise a processor, memory accessible by the processor, and computer program instructions stored in the memory and executable by the processor, the method may comprise: when a user process makes a system call, switching to kernel mode and using a system call page table for the user process to execute a system call handler, when the system call handler attempts to access unmapped kernel space memory, generating a page fault, and handling the page fault by determining whether the attempted access to unmapped kernel space memory is allowed.Type: ApplicationFiled: May 19, 2019Publication date: November 19, 2020Inventors: James Bottomley, Joel Kelly Nider, Michael Rapoport
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Publication number: 20170350893Abstract: The invention relates to a method of determining an increased risk of cancer in an immunosuppressed patient, the method comprising: (a) determining the percentage of CD8+CD57+ T-cells in a population of CD8+ T-cells in a sample from the patient; wherein a percentage of 40% or greater of CD8+CD57+ T-cells is indicative of an increased risk of cancer; and/or (b) determining the percentage of CD4+CD57+ T-cells in a population of CD4+ T-cells in a sample from the patient; wherein a percentage of 10% or greater of CD4+CD57+ T-cells is indicative of an increased risk of cancer.Type: ApplicationFiled: October 23, 2015Publication date: December 7, 2017Inventors: Paul Neil HARDEN, Kathyrn Jayne WOOD, Matthew James BOTTOMLEY
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Patent number: 9716688Abstract: A method, system and computer program product for a VPN for containers and VMs implemented on different network node. A number of network hardware nodes have containers and VMs running on them. The containers and VMs are aggregated into VPNs assembled across the hardware nodes. Each hardware node has a network edge programmable switch configured to route packets to containers and VMs only inside a particular VPN. The switch detects a number of the VPN inside the packet header, replaces this number by a standard broadcast header number and multi-casts the packet to the containers and the VMs inside the VPN.Type: GrantFiled: January 6, 2017Date of Patent: July 25, 2017Assignee: Parallels International GmbHInventors: Pavel Emelyanov, James Bottomley
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Patent number: 9548964Abstract: A method, system and computer program product for a VPN for containers and VMs implemented on different network node. A number of network hardware nodes have containers and VMs running on them. The containers and VMs are aggregated into VPNs assembled across the hardware nodes. Each hardware node has a network edge programmable switch configured to route packets to containers and VMs only inside a particular VPN. The switch detects a number of the VPN inside the packet header, replaces this number by a standard broadcast header number and multi-casts the packet to the containers and the VMs inside the VPN.Type: GrantFiled: October 25, 2016Date of Patent: January 17, 2017Assignee: Parallels International GmbHInventors: Pavel Emelyanov, James Bottomley
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Patent number: 9485219Abstract: A method, system and computer program product for a VPN for containers and VMs implemented on different network node. A number of network hardware nodes have containers and VMs running on them. The containers and VMs are aggregated into VPNs assembled across the hardware nodes. Each hardware node has a network edge programmable switch configured to route packets to containers and VMs only inside a particular VPN. The switch detects a number of the VPN inside the packet header, replaces this number by a standard broadcast header number and multi-casts the packet to the containers and the VMs inside the VPN.Type: GrantFiled: May 13, 2015Date of Patent: November 1, 2016Assignee: Parallels IP Holdings GmbHInventors: Pavel Emelyanov, James Bottomley
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Patent number: 5500068Abstract: An absorbent, flushable, bio-degradable, and medically-safe nonwoven fabric suitable for use as wraps, wipes, absorbent pads, etc., is composed of from 2% to 10% by weight of untreated, water-soluble polyvinyl alcohol (PVA) fibers that are heat-bonded to a matrix of absorbent fibers. The use of PVA fibers in low amounts provides softness, while sufficient wet strength is provided by heat bonding the PVA fibers completely to the other fibers in a two-stage heating process. The resulting nonwoven fabric has a high wet-to-dry tensile strength ratio, good drape softness, and high fluid absorptive capacity. In a method for producing the nonwoven fabric, the PVA fibers are blended with the absorbent fibers, the blended fibers are carded onto a moving web, sufficient water is added to wet the PVA fibers while maintaining web integrity, then the web is heated in two stages, the first with heating cylinders at 40.degree. C. to 80.degree. C., then the second with heating cylinders of 60.degree. C. to 100.degree. C.Type: GrantFiled: June 5, 1995Date of Patent: March 19, 1996Assignee: International Paper CompanyInventors: Ramesh Srinivasan, James Bottomley, W. Andrew Coslett
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Patent number: 5500281Abstract: An absorbent, flushable, bio-degradable, and medically-safe nonwoven fabric suitable for use as wraps, wipes, absorbent pads, etc., is composed of from 2% to 10% by weight of untreated, water-soluble polyvinyl alcohol (PVA) fibers that are heat-bonded to a matrix of absorbent fibers. The use of PVA fibers in low amounts provides softness, while sufficient wet strength is provided by heat bonding the PVA fibers completely to the other fibers in a two-stage heating process. The resulting nonwoven fabric has a high wet-to-dry tensile strength ratio, good drape softness, and high fluid absorptive capacity. In a method for producing the nonwoven fabric, the PVA fibers are blended with the absorbent fibers, the blended fibers are carded onto a moving web, sufficient water is added to wet the PVA fibers while maintaining web integrity, then the web is heated in two stages, the first with heating cylinders at 40.degree. C. to 80.degree. C., then the second with heating cylinders of 60.degree. C. to 100.degree. C.Type: GrantFiled: February 23, 1994Date of Patent: March 19, 1996Assignee: International Paper CompanyInventors: Ramesh Srinivasan, James Bottomley, W. Andrew Coslett
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Patent number: D803599Type: GrantFiled: October 30, 2014Date of Patent: November 28, 2017Inventor: Timothy James Bottomley