Abstract: The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: Disclosed are novel compounds which inhibit RSK, methods of making such compounds and pharmaceutical compositions comprising such compounds. Also disclosed are methods of treating RSK2 regulated disorders using compounds of the invention.

Abstract: Methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using substituted pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents.

Abstract: Disclosed are compounds of formula (I) and compositions of the present invention which are inhibitors of the sodium proton exchanger isoform-1 (NHE-I). Also disclosed are methods of using and making the same.

Abstract: The present invention is related to treated filler and processes for producing said treated filler. Untreated filler slurry can be treated with a treating material and, optionally, a coupling material and then subjected to conventional drying method(s), to produce the treated filler of the invention. Treated filler has a wide variety of applications including but not limited to battery separators and rubber compositions such as tires.

Abstract: The present invention is related to treated filler and processes for producing said treated filler. Untreated filler slurry can be treated with a treating material and then subjected to conventional drying method(s), to produce the treated filler of the invention. Treated filler has a wide variety of applications including but not limited to battery separators and rubber compositions such as tires.

Abstract: The present invention is related to treated filler and processes by which it can be produced. Untreated filler slurry can be treated with a treating material and then subjected to conventional drying method(s), to produce the treated filler of the invention. Treated filler has a wide variety of applications including but not limited to battery separators and rubber compositions such as tires.

Abstract: The present invention is related to treated filler, processes for producing said treated filler and the use of said treated filler in polymeric compositions. In particular, filler can be treated with at least one non-coupling material and at least one coupling material, then subjected to conventional drying method(s), to produce the treated filler of the present invention. The resultant treated filler has a wide variety of applications including polymeric compositions such as but not limited to rubber compositions such as tires.

Abstract: Substituted and Fused pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.

Abstract: An ignition coil, spark plug, and pressure sensor for an internal combustion engine are, in a preferred embodiment, integrated into a single assembly and mounted directly on a plug hole of an internal combustion engine. A hard spark plug shell serves as a pressure member and on which a strain gage is affixed. Changes in the pressure in the combustion chamber deform the shell, causing a corresponding change in the resistance of the strain gage. A bridge circuit or the like is used to measure the resistance change thereby providing a direct indication of cylinder pressure.

Abstract: A device for simultaneously and evenly toasting articles of differing contours and dimensions arranged upon a heated griddle. A clamshell plate, positioned in stand-off relationship above said griddle-arranged articles, has a plurality of slideably moveable fingers or pins mounted therein which float, that is, are brought into contacting and resting relation with the upper surfaces of said articles to provide a gentle pressure thereon to urge the lower surfaces into more intimate contact with the griddle until the toasting process is completed, thereby accelerating the toasting process without undesirable side effects such as distortion of, and condensation on, the upper surfaces and caramelization of the lower surfaces of said articles.

Abstract: Substituted and pyridines and pyridazines having angiogenesis inhibiting activity and the generalized structural formula 1

Abstract: Substituted pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.

Abstract: A monitoring system for adjusting a light source for a counting cell signal in a counting and dispensing system, which light deteriorates over time as a result of dust accumulation from the handling of pills, capsules, and tablets. The monitoring system uses electronics to adjust the light relative to the dust accumulation, thus maintaining an accurate counting cell signal, so that the system can continue to function. In this respect, the monitoring system provides for longer intervals between required maintenance operations, and therefore reduces the cost of operation.

Abstract: A device for simultaneously and evenly toasting articles of differing contours and dimensions arranged upon a heated griddle. A clamshell plate, positioned in stand-off relationship above said griddle-arranged articles, has a plurality of slideably moveable fingers or pins mounted therein which float, that is, are brought into contacting and resting relation with the upper surfaces of said articles to provide a gentle pressure thereon to urge the lower surfaces into more intimate contact with the griddle until the toasting process is completed, thereby accelerating the toasting process without undesirable side effects such as distortion of, and condensation on, the upper surfaces and caramelization of the lower surfaces of said articles.

Abstract: A laminating heating module for use in a flatbed laminating machine. The heating module comprises an elongate body portion with at least one heating pad attached thereto. The heating pad is fabricated from silicone rubber and includes three separate heating zones for regulating the heat to the body portion. Attached to each heating zone of the heating pad is a respective thermocouple to control the temperature of each heating zone. The heating module further comprises a thermostat attached to the heating pad and operative to protect the temperature of the body portion of the heating module from overheating.

Abstract: A lamination machine for adhesively heat laminating adjacent surfaces of two lengths of material to each other. The machine includes a flatbed pre-laminating station with upper and lower pre-lamination conveyor belts and banks of heater components immediately above and below. At least one pre-lamination belt is vertically movable to establish and adjust a gap between belts while its associated bank of heating elements is vertically pressuredly movable to thereby tightly maintain proximity of heater elements, belts, and laminate materials. Situated immediately downstream is a pressure roller independently vertically movable to establish and adjust laminate gap distance and, during lamination operation, tensioned against a lower conveyor belt guide roller and movable by a roller pressure driver toward the guide roller.

Abstract: A lamination machine for adhesively heat laminating adjacent surfaces of two or more layers of material to each other. The machine includes upper and lower opposing conveyor belts disposed one above the other to form a lamination passage therebetween and through which layers of material travel during lamination. At least one pressure roller is tensioned against the layers to be laminated. A heating module is disposed between the entrance and pressure roller, while a cooling module is disposed between the pressure roller and an exit. The heating module provides a plurality of rigidly maintained single-structure extruded heater components for melting an adhesion constituent disposed between the layers of material in preparation for lamination.

Abstract: A digitally controlled, manually actuated press comprising a housing having a lower platen attached thereto. The lower platen defines a generally planar top surface. Pivotally connected to the housing are left and right actuation handles, each of which is selectively movable between a loading/unloading and a press position. The press further comprises left and right transitional leveling members which are cooperatively engaged to respective ones of the actuation handles. Also included in the press are left and right upper platens which are cooperatively engaged to respective ones of the leveling members. Each of the upper platens define a generally planar bottom surface. In the press, each of the leveling members is configured to facilitate the rotation of the bottom surface of the corresponding upper platen into generally parallel relation to the top surface during the movement of the corresponding actuation handle from its loading/unloading position to its press position.

Abstract: A lamination machine for adhesively heat laminating adjacent surfaces of two lengths of material to each other. The machine includes a flatbed pre-laminating station with upper and lower pre-lamination conveyor belts and banks of heater components immediately above and below. At least one pre-lamination belt is vertically movable to establish and adjust a gap between belts while its associated bank of heating elements is vertically pressuredly movable to thereby tightly maintain proximity of heater elements, belts, and laminate materials. Situated immediately downstream is a pressure roller independently vertically movable to establish and adjust laminate gap distance and, during lamination operation, tensioned against a lower conveyor belt guide roller and movable by a roller pressure driver toward the guide roller.