Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Tumors utilize multiple mechanisms to avoid the host's anti-tumor immune response. Humoral immunosuppression is one of the mechanisms. Tumors produce circulating factors that can suppress antibody or complement-mediated immune responses to enhance their own survival. Mesothelin is a cell surface protein overexpressed by several cancer types that are associated with tumors exhibiting immunosuppressed microenvironments. Anti-mesothelin antibodies are often subject to such immunosuppressive microenvironments. Alternatively formatted anti-mesothelin antibodies, however, are effective in killing mesothelin-expressing cancers irrespective of tumor microenvironment immune status.

Abstract: The CA125/MUC16 protein has been found to be a suppressor of humoral immunity, in particular, antibody-mediated humoral immunity mediated through the direct binding to a subset of antibodies. Antibody variants can be generated that have reduced or eliminated CA125 binding yet retain the antigen specificity of the parental antibody. These can be used in treating patients with elevated CA125. CA 125-refractory antibodies are developed and used for treatment. Additionally, proteins that enhance humoral immunity in the presence of CA125 can be used to counter the suppression of humoral immunity.

Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.

Abstract: A transport trailer includes a chassis, a deck, a lifting assembly, and a stabilizer assembly. The lifting assembly is mechanically coupled to the deck and the chassis and selectively raises and lowers the deck relative to the chassis. The stabilizer assembly includes a support post and a slide member. The support post is laterally disposed between first and second edges of the deck and extends from the chassis to a top end of the support post. The slide member is coupled to the deck and translates along a length of the support post as the deck is raised and lowered to stabilize the deck. An upper surface of the deck is above the top end of the support post when the deck is in a raised position and is below the top end of the support post when the deck is in a lowered position.

Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.

Abstract: The present subject matter relates to systems, assemblies, and methods for connecting structural members together. A connector assembly includes an elongated track having a web, opposed edge portions that extend from a first surface of the web and that form a pair of slide channels, and one or more protrusions protruding from a second surface of the web opposing the first surface, the one or more protrusions being configured to connect to the first building member. A connecting member is adapted to connect to the second building member and includes a base that retains the connecting member to the channels but is movable within the channels along the track. In this configuration, when the connector assembly is connected between the first and second building members, the connecting member is movable in the track in response to relative movement between the first and second building members.

Abstract: Pipe-handling tool for use in a drilling rig catwalk. A V-shaped pipe kicker plate is mounted in a pipe trough and has a pinned end mounted for rotation about the pin and a free end. An actuator has an extendable rod end attached to the kicker plate. The extendable rod has telescopically engaged first and second stages. An annular first stage piston is slidably disposed to engage a drive end of the first stage of the rod. A first stage gland slidably receives the first stage of the rod. A second stage piston is slidably disposed within the first stage piston to engage a drive end of the second stage of the rod. The first stage can have a longer stroke than the first stage, whereas the second stage can have a higher stroke velocity to assist kicking the pipe from the trough.

Abstract: The CA125/MUC16 protein has been found to be a suppressor of humoral immunity, in particularly antibody-mediated humoral immunity. The generation of antagonists that can block its immune suppressive effects on antibodies may lead to enhanced therapeutic responses by antibodies that are negatively impacted by CA125/MUC16. In addition, it offers the ability to unlock humoral immune suppression of a patient's endogenous humoral response that may be suppressed by CA125/MUC16 suppression. CA125/MUC16 antagonists can be used to enhance humoral response of therapeutic antibodies and patients with CA125/MUC16-expressing diseases, including cancer.

Abstract: An apparatus for cleaning an inner surface of a slot includes a first block segment that has an outer perimeter that conforms to and fits inside the inner surface of the slot. A first cleaning pad is connected to the first block segment and extends beyond at least a portion of the outer perimeter of the first block segment.

Abstract: A grill shield is provided for use with grills, some may be Kamado style grills. The shield can be provided in upper and lower shield portions which respectively connect to the top and the bottom of the grill. The shield portion(s) can connect with brackets to provide an air gap about the exterior surface of the grill and the shield thereby permitting the shield to be at a lower temperature than an exterior surface of the grill.

Abstract: A fluid collection and retention system is provided. In some embodiments, the system is integrated with and comprises a retaining wall structure, and the retaining wall structure forms at least a portion of an enclosed volume of a module for collecting and storing fluid. Various features of a fluid retention module and related supporting structures are also provided.

Abstract: An apparatus and method for servicing a combustion liner in a combustion case of a turbine is provided. The apparatus includes an elongated bar having a handle at one end and a force applying member at an opposing end of the elongated bar. An attachment member is configured for attachment to a flange of the combustion case. The attachment member is also configured for pivotal attachment to the elongated bar. The apparatus is configured to apply a radially outward force on a downstream portion of the combustion liner when a radially inward force is applied to the handle.

Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.

Abstract: A tool for installing a turbomachine component in a first dovetail slot of a first component mount is provided. The tool may include a tool mount having a body for selective fixing in a second dovetail slot of a second component mount adjacent to the first component mount. The tool may also include a lever arm including a first portion, an intermediate pivot for pivotally engaging the tool mount, and a second portion for engaging the turbine component. Actuating the lever arm against the tool mount causes the second portion of the lever arm to install the turbomachine component into the first dovetail slot of the first component.

Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.