Abstract: Systems and methods for protein engineering. The systems include a sequence testing subsystem and a machine learning subsystem. The sequence testing subsystem is configured to express proteins and test the expressed proteins for a given property. The machine learning subsystem is configured to model the activities of a set of possible proteins in light of the properties of the tested proteins and provide one or more untested proteins in the set to the sequence testing subsystem for subsequent testing. The system can be run in an iterative fashion and be fully automated. Methods of using the systems are provided.

Abstract: A collimator is compact and uses power efficient light emitting diodes as the illumination source to generate a test image in collimated space. The collimator provides a test image across a wide field of view, which is useful for calibration of optical devices that have a wide field of regard. An optical projection system in the collimator utilizes an array of light emitting diodes, whose light is converged by a Fresnel lens, through a holographic diffuser plate, onto a target plate bearing the test pattern to be projected out into collimated space through a converging lens. An alignment structure provides translation of the target plate along the main axis of the collimator and provides rotational freedom about two axes (vertical and horizontal) via a gimbal structure mounted on the translation mechanism.