Patents by Inventor James Brian Thoden

James Brian Thoden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline 1&agr;-hydroxyvitamin D2 and method of purification thereof
    Patent number: 6462031
    Abstract: A method of purifying 1&agr;-hydroxyvitamin D2 to obtain 1&agr;-hydroxyvitamin D2 in crystalline form. The method includes the steps of boiling a solvent selected from the group consisting of ethyl formate, ethyl acetate and a 2-propanol-hexane mixture under inert atmosphere, dissolving a product containing 1&agr;-hydroxyvitamin D2 to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of 1&agr;-hydroxyvitamin D2 crystals, and recovering the 1&agr;-hydroxyvitamin D2 crystals. Petroleum ether is also added to the solvent after dissolving the product to be purified in the solvent.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: October 8, 2002
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Rafal R. Sicinski, Hazel Holden, James Brian Thoden
  • Crystalline 1&agr;-hydroxyvitamin D2 and method of purification thereof
    Patent number: 6432936
    Abstract: A method of purifying 1&agr;-hydroxyvitamin D2 to obtain 1&agr;-hydroxyvitamin D2 in crystalline form. The method includes the steps of boiling a solvent selected from the group consisting of ethyl formate, ethyl acetate and a 2-propanol-hexane mixture under inert atmosphere, dissolving a product containing 1&agr;-hydroxyvitamin D2 to be purified in the. solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of 1&agr;-hydroxyvitamin D2 crystals, and recovering the 1&agr;-hydroxyvitamin D2 crystals. Optionally, petroleum ether may be added to the solvent after dissolving the product to be purified in the solvent.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: August 13, 2002
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Rafal R. Sicinski, Hazel Holden, James Brian Thoden
  • Crystalline 1&agr;, 24(S)-dihydroxyvitamin D2 and method of purification thereof
    Patent number: 6362350
    Abstract: A method of purifying 1&agr;,24(S)-dihydroxyvitamin D2 to obtain 1&agr;,24(S)-dihydroxyvitamin D2 in crystalline form. The method includes the steps of boiling a solvent under inert atmosphere, dissolving a product containing 1&agr;,24(S)-dihydroxyvitamin D2 to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of 1&agr;,24(S)-dihydroxyvitamin D2 crystals, and recovering the 1&agr;,24(S)-dihydroxyvitamin D2 crystals. The purification technique involves using one of several binary solvent systems, namely, acetone and hexane, 2-propanol and hexane, or ethyl formate and petroleum ether.
    Type: Grant
    Filed: November 10, 1999
    Date of Patent: March 26, 2002
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Rafal R. Sicinski, Hazel Holden, James Brian Thoden
  • Crystalline1alpha,24(S)-dihydroxyvitamin D2 and method of purification thereof
    Publication number: 20010051738
    Abstract: A method of purifying 1&agr;,24(S)-dihydroxyvitamin D2 to obtain 1&agr;,24(S)-dihydroxyvitamin D2 in crystalline form. The method includes the steps of boiling a solvent under inert atmosphere, dissolving a product containing 1&agr;,24(S)-dihydroxyvitamin D2 to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of 1&agr;,24(S)-dihydroxyvitamin D2 crystals, and recovering the 1&agr;,24(S)-dihydroxyvitamin D2 crystals. The purification technique involves using one of several binary solvent systems, namely, acetone and hexane, 2-propanol and hexane, or ethyl formate and petroleum ether.
    Type: Application
    Filed: June 22, 2001
    Publication date: December 13, 2001
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Rafal R. Sicinski, Hazel Holden, James Brian Thoden
  • Crystalline 1alpha-hydroxyvitamin D2 and method of purification thereof
    Publication number: 20010039359
    Abstract: A method of purifying 1&agr;-hydroxyvitamin D2 to obtain 1&agr;-hydroxyvitamin D2 in crystalline form. The method includes the steps of boiling a solvent selected from the group consisting of ethyl formate, ethyl acetate and a 2-propanol-hexane mixture under inert atmosphere, dissolving a product containing 1&agr;-hydroxyvitamin D2 to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of 1&agr;-hydroxyvitamin D2 crystals, and recovering the 1&agr;-hydroxyvitamin D2 crystals. Petroleum ether is also added to the solvent after dissolving the product to be purified in the solvent.
    Type: Application
    Filed: December 15, 2000
    Publication date: November 8, 2001
    Inventors: Hector F. DeLuca, Rafal R. Sicinski, Hazel Holden, James Brian Thoden