Patents by Inventor James Briscoe

James Briscoe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetic demonstration of requirement for NKX6.1 and NKX2.2 in ventral neuron generation
    Patent number: 7393686
    Abstract: This invention provides a method of converting a stem cell into a ventral neuron which comprises introducing into the stem cell a nucleic acid which expresses homeodomain transcription factor Nkx6.1 protein in the stem cell so as to thereby convert the stem cell into the ventral neuron. Provided are methods of diagnosing a motor neuron degenerative disease in a subject. Also provides is a method of treating neuronal degeneration in a subject which comprises implanting in diseased neural tissue of the subject a neural stem cell which comprises an isolated nucleic acid molecule which is capable of expressing homeodomain Nkx6.1 protein under conditions such that the stem cell is converted into a motor neuron after implantation, thereby treating neuronal degeneration in the subject.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: July 1, 2008
    Assignees: Trustees of Columbia University in the City of New York, The Regents of the University of California
    Inventors: Thomas M. Jessell, James Briscoe, Johan Ericson, John L. R. Rubenstein, Maike Sander
  • Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation
    Patent number: 7312081
    Abstract: This invention provides a method of converting a stem cell into a ventral neuron which comprises introducing into the stem cell a nucleic acid which expresses homeodomain transcription factor Nkx6.1 or Nkx6.2 protein in the stem cell so as to thereby convert the stem cell into the ventral neuron. Provided are methods of diagnosing a motor neuron degenerative disease in a subject. Also provides is a method of treating neuronal degeneration in a subject which comprises implanting in diseased neural tissue of the subject a neural stem cell which is capable of expressing homeodomain Nkx6.1 or Nkx6.2 protein under conditions such that the stem cell is converted into a motor neuron after implantation, thereby treating neuronal degeneration in the subject.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: December 25, 2007
    Assignees: The Trustees of Columbia University in the City of New York, The Regents of the University of California
    Inventors: Thomas M. Jessell, James Briscoe, Johan Ericson, John L. R. Rubenstein, Maike Sander
  • Homeodomain protein code specifying progenitor cell identify and neuronal fate in the ventral neural tube
    Patent number: 6955802
    Abstract: Provided are genetically engineered cells comprising a neural stem cell and retroviral expression system in the neural stem cell, which is capable of expressing homeodomain transcription factor Nkx6.1 protein but does not express homeodomain transcription factor Irx3 protein or homeodomain transcription factor Nkx2.2 protein; which is capable of expressing homeodomain transcription factor Nkx6.1 protein and homeodomain transcription factor Irx3 protein; and which is capable of expressing homeodomain transcription factor Nkx2.2 protein or homeodomain transcription factor Nkx2.9 protein. Also provided are methods of generating such genetically engineered motor neurons, V2 neurons, and V3 neurons.
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: October 18, 2005
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Thomas M. Jessell, James Briscoe, Johan Ericson
  • Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation
    Publication number: 20040053210
    Abstract: This invention provides a method of converting a stem cell into a ventral neuron which comprises introducing into the stem cell a nucleic acid which expresses homeodomain transcription factor Nkx6.1 or Nkx6.2 protein in the stem cell so as to thereby convert the stem cell into the ventral neuron. Provided are methods of diagnosing a motor neuron degenerative disease in a subject. Also provides is a method of treating neuronal degeneration in a subjet which comprises implanting in diseased neural tissue of the subject a neural stem cell which is capable of expressing homeodomain Nkx6.1 or Nkx6.2 protein under conditions such that the stem cell is converted into a motor neuron after implantation, thereby treating neuronal degeneration in the subject.
    Type: Application
    Filed: August 1, 2003
    Publication date: March 18, 2004
    Inventors: Thomas M. Jessell, James Briscoe, Johan Ericson, John L.R. Rubenstein, Maike Sander