Abstract: A medical system for obstructive sleep apnea (OSA) treatment includes therapy delivery circuitry configured to output one or more electrical stimulation signals to a tongue of a patient; sensing circuitry configured to sense one or more compound muscle action potential (CMAP) signals, wherein the one or more CMAP signals are generated in response to the delivery of the one or more electrical stimulation signals; and processing circuitry configured to: cause the therapy delivery circuitry to output the one or more electrical stimulation signals to the tongue; receive information indicative of the one or more CMAP signals from the sensing circuitry; determine, based on the one or more CMAP signals, one or more therapeutic stimulation parameters for the OSA treatment; and cause the therapy delivery circuitry to deliver therapeutic electrical stimulation signals according to at least the determined one or more therapeutic stimulation parameters.

Abstract: An apparatus for monitoring EMG signals of a patient's laryngeal muscles includes an endotracheal tube having an exterior surface. Conductive electrodes are formed on the endotracheal tube. The conductive electrodes are configured to receive the EMG signals from the laryngeal muscles when the endotracheal tube is placed in a trachea of the patient. At least wireless sensor is formed on the endotracheal tube, and is configured to wirelessly transmit information to a processing apparatus.

Abstract: An ablation system includes an ablation device having an electrode configured to deliver electrosurgical energy to tissue and an electrosurgical generator configured to deliver electrosurgical energy to the electrode. The electrosurgical generator is also configured to calculate a number of Joules of electrosurgical energy delivered to the electrode. The ablation system also includes a feedback device. The feedback device is configured to provide feedback (e.g., audible and/or visual) correlated with the calculated number of Joules of electrosurgical energy delivered to the electrode.

Abstract: Disclosed are surfactants, as well as methods of using thereof in oil and gas operations.

Abstract: Disclosed are co-solvents as well as methods of using thereof in oil and gas operations. Described herein are also methods of displacing an unrefined petroleum material in contact with a solid material, said method comprising: contacting the unrefined petroleum material with the compound described herein or a composition described herein, wherein the unrefined petroleum material is in contact with the solid material; and allowing the unrefined petroleum material to separate from the solid material, thereby displacing the unrefined petroleum material in contact with the solid material.

Abstract: Disclosed are compounds as well as methods of using thereof in oil and gas operations. The compounds described herein can be used in Enhanced Oil Recovery (EOR) formulations to provide aqueous stability and ultra-low interfacial tension region. Accordingly, also provided are aqueous compositions for use in EOR that comprise the compounds described herein.

Abstract: A system for ablating a thyroid nodule using a moving shot technique includes an ablation device configured to be inserted into a thyroid nodule. The ablation device has an electrode configured to be retracted along an axis defined through the thyroid nodule while delivering energy to the thyroid nodule. The system also includes an electrosurgical generator configured to delivery energy to the ablation device. An audio device is in communication with the electrosurgical generator. The audio device is configured to broadcast a sound correlated with at least one sensed tissue property such that the audio device changes the sound in response to a change in the at least one sensed tissue property.

Abstract: Methods are provided for predicting the efficacy of midostaurin for the treatment of a cancer in an individual subject or a cohort of patients. The method comprises determining a phosphoproteomic and/or a proteomic signature within a sample obtained from the individual subject wherein the phosphoproteomic and/or proteomic signature provides a personalised prediction for the individual subject of the efficacy of midostaurin for treatment of cancer. This invention has utility in methods for treatment of a range of cancers including acute myeloid leukaemia (AML). Companion diagnostic kits and their use in dosage regimens for the treatment of cancer are also provided.

Abstract: An implantable neurostimulator (INS) and method of use, the INS including an electrical lead having formed thereon at least a pair of bi-polar electrodes, wherein the electrical lead is configured for placement of the pair of bi-polar electrodes proximate protrusor muscles of a patient, a pulse generator electrically connected to the electrical lead and configured to deliver electrical energy to the pair of bi-polar electrodes, the pulse generator having mounted therein a sensor and a control circuit, and the sensor is configured to generate signals representative of an orientation of the pulse generator and communicate the signals to the control circuit and the control circuit is configured to determine the orientation of the pulse generator and deliver electrical energy to the bi-polar electrodes when the determined orientation correlates to a pre-determined orientation.

Abstract: A system includes memory, and processing circuitry coupled to the memory, the processing circuitry configured to: determine at least one of: a cross-electrical signal measurement at a first electrode on a first lead implanted within a tongue of the patient based on a stimulation signal between a second electrode on the first lead or a second lead implanted within the tongue of the patient and a third electrode, or a strain measurement of at least one of the first lead or the second lead. The processing circuitry is configured to determine movement of the tongue based on at least one of the cross-electrical signal measurement or the strain measurement, and generate information indicative of the movement of the tongue.

Abstract: A system operable to allowing viewing of a physical subject with information regarding at least an item separate from the subject overlaid thereon. The system includes a viewscreen. The system is further able to determine the position of the item relative to the subject.

Abstract: A first medical device for obstructive sleep apnea therapy includes therapy delivery circuitry coupled to a first set of electrodes implantable proximate to a first hypoglossal nerve within a tongue of the patient and configured to deliver a first electrical stimulation signal to the first hypoglossal nerve that causes the tongue of the patient to advance and includes information to communicate to a second medical device implantable within the head or neck of the patient and coupled to a second set of electrodes implantable proximate to a second hypoglossal nerve within the tongue of the patient; and sensing circuitry coupled to the first set of electrodes and configured to receive a second electrical stimulation signal, delivered to the second hypoglossal nerve by the second medical device, that includes information that the second medical device communicates to the first medical device.

Abstract: A medical system for obstructive sleep apnea (OSA) treatment includes therapy delivery circuitry configured to output one or more electrical stimulation signals to a tongue of a patient; sensing circuitry configured to sense one or more compound muscle action potential (CMAP) signals, wherein the one or more CMAP signals are generated in response to the delivery of the one or more electrical stimulation signals; and processing circuitry configured to: cause the therapy delivery circuitry to output the one or more electrical stimulation signals to the tongue; receive information indicative of the one or more CMAP signals from the sensing circuitry; determine, based on the one or more CMAP signals, one or more therapeutic stimulation parameters for the OSA treatment; and cause the therapy delivery circuitry to deliver therapeutic electrical stimulation signals according to at least the determined one or more therapeutic stimulation parameters.

Abstract: Disclosed is a system for stimulation of a subject. The stimulation may be to provide therapy to treat the subject. Stimulation may be of selected muscle groups and/or portions.

Abstract: A first medical device for obstructive sleep apnea therapy includes therapy delivery circuitry coupled to a first set of electrodes implantable proximate to a first hypoglossal nerve within a tongue of the patient and configured to deliver a first electrical stimulation signal to the first hypoglossal nerve that causes the tongue of the patient to advance and includes information to communicate to a second medical device implantable within the head or neck of the patient and coupled to a second set of electrodes implantable proximate to a second hypoglossal nerve within the tongue of the patient; and sensing circuitry coupled to the first set of electrodes and configured to receive a second electrical stimulation signal, delivered to the second hypoglossal nerve by the second medical device, that includes information that the second medical device communicates to the first medical device.

Abstract: Disclosed is a system for stimulation of a subject. The stimulation may be to provide therapy to treat the subject. Stimulation may be of selected muscle groups and/or portions.

Abstract: An implantable neurostimulator (INS) and method of use, the INS including an electrical lead having formed thereon at least a pair of bi-polar electrodes, wherein the electrical lead is configured for placement of the pair of bi-polar electrodes proximate protrusor muscles of a patient, a pulse generator electrically connected to the electrical lead and configured to deliver electrical energy to the pair of bi-polar electrodes, the pulse generator having mounted therein a sensor and a control circuit, and the sensor is configured to generate signals representative of an orientation of the pulse generator and communicate the signals to the control circuit and the control circuit is configured to determine the orientation of the pulse generator and deliver electrical energy to the bi-polar electrodes when the determined orientation correlates to a pre-determined orientation.

Abstract: Disclosed is a system for stimulation of a subject. The stimulation may be to provide therapy to treat the subject. Stimulation may be of selected muscle groups and/or portions.

Abstract: Disclosed is a system for stimulation of a subject. The stimulation may be to provide therapy to treat the subject. Stimulation may be of selected muscle groups and/or portions.

Abstract: Disclosed is a system for stimulation of a subject. The stimulation may be to provide therapy to treat the subject. Stimulation may be of selected muscle groups and/or portions.