Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of CTNNB1 gene expression and/or activity, and/or modulate a beta-catenin gene expression pathway. Specifically the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against CTNNB1 gene expression.

Abstract: A vehicle guidance system and method includes at least one guidance sensor configured to mount on or adjacent to a pantograph along a lateral width of the pantograph. The pantograph installs on a vehicle and conducts electrical energy from a conductive pathway as the vehicle travels along a route. The vehicle guidance system and method includes a controller that receives one or more sensor signals generated by the at least one guidance sensor and determines a lateral position of the conductive pathway relative to the pantograph based on the one or more sensor signals.

Abstract: A heating circuit has at least three series-connected resistance-heating elements, each resistance-heating element being connected between a pair of nodes, each pair of adjacent resistance-heating elements in the series being connected via one of the nodes, each node being connectable to a voltage. Optionally, the heating circuit may have one or more switching elements to allow selective connection of one or more voltages to the resistance heating elements.

Abstract: A limb positioning and support device for achieving and maintaining reduction of a human bone in connection with surgical procedures involving orthopedic and other surgical fracture tables. The limb positioning and support device includes an articulating and rotating positioning and support arm coupled between a surgical table and a limb saddle. The positioning and support arm is configured to selectively allow translation and/or rotation of the limb saddle in three degrees of freedom. Actuation mechanisms drive the limb saddle vertically and horizontally. A pivot joint coupled between the limb saddle and the positioning and support arm permits rotation of the limb saddle about a vertical axis, and the limb saddle can be angularly displaced about the longitudinal axis of the subject limb. The limb saddle can be positioned and adjusted to bring fractured bone ends into alignment and hold the fracture stationary during the surgical procedure.

Abstract: Method of processing a polycrystalline diamond element may include laser ablating at least a portion of a polycrystalline diamond element to form a laser-shaped surface and exposing at least a portion of the laser-shaped surface to a leaching solution to define a leached polycrystalline diamond volume and an unleached polycrystalline diamond volume.

Abstract: A computer system and computer-implemented method for duplicating an application state are provided, the method including: recording one or more point-in-time characteristics generated by prior user inputs at one or more user interface elements, the one or more point-in-time characteristics associated with a first application state of a first application instance; transferring the one or more point-in-time characteristics to the provisioned memory resources for generating the second application state; generating a second application instance based on the one or more point-in-time characteristics; configuring the second application state based on the one or more point-in-time characteristics to duplicate the first application state of the first application instance; and storing the prior user inputs in a journal, wherein the journal is configured to enable reproduction of a state of a plurality of modified states of the first application instance.

Abstract: A packaging container for a car floor mat including: a main body; at least one post member extending from the main body for supporting the car floor mat, and a securing arrangement releasably secured to the post member, the car floor mat being retained on the post member when the securing arrangement is secured to the post member, the car floor mat being removable from the packaging container when the securing arrangement is released from the post member, wherein the securing arrangement includes a catch supported on the main body by a hinged connection, the catch including a ring member for encircling the post member when engaging the post member, the ring member having an inwardly directed engagement member for engaging an overbite provided on the post member when the catch is hinged towards and interlocks with the post member.

Abstract: An improved configuration for a bearing housing assembly is disclosed herein in which a ring can be configured to be secured in at least two positions such that the bearing assembly positioned inside of the housing can be retained in either a fixed state or a floating state. The ring can be configured to be secured at least partially within the housing in at least a first configuration and a second configuration, such that: (i) the ring is configured to abut the bearing assembly in the first configuration such that the bearing assembly is axially fixed relative to the housing, and (ii) the ring is configured to be spaced apart from the bearing assembly in the second configuration such that the bearing assembly is axially displaceable within the housing.

Abstract: Provided herein are systems and methods for storing digital information by assembling an identifier nucleic acid molecule from at least a first component nucleic acid molecule and a second component nucleic acid molecule. The system may include a first printhead configured to dispense a first droplet of a first solution comprising the first component nucleic acid molecule onto a coordinate on a substrate, and a second printhead configured to dispense a second droplet of a second solution comprising the second component nucleic acid molecule onto the coordinate on the substrate, such that the first and second component nucleic acid molecules are collocated on the substrate. The system may include a finisher that dispenses a reaction mix onto the coordinate on the substrate to physically link the first and second component nucleic acid molecules, provides a condition necessary to physically link the first and second component nucleic acid molecules, or both.

Abstract: Disclosed are techniques, devices and systems that provide a compact reservoir and plunger arrangement. In the disclosed examples, a reservoir may include a housing, a plunger, a lead screw and an elastic sleeve. The housing may have a first end and a second end. The plunger may be configured to fit within the housing. The leadscrew may be coupled to the plunger. The elastic sleeve may surround the leadscrew and be coupled to a surface of the plunger and to a surface of the second end of the housing. The elastic sleeve is leakproof.

Abstract: A method of encryption key provisioning that includes providing, by a quantum computing safe method, a shared secret data to a device and to a security service; using the provided shared secret data to provide a root key; and using the root key for a sequence of stages, wherein each stage includes an operation which converts a start key into a different generated key, and the same stages are carried out in parallel at the device and at the security service; wherein the root key is used as the start key for a first stage, and a generated key produced by each stage, except for the final stage, is used as a start key for a next stage of the sequence; and wherein the generated keys produced by the last stage of the sequence at the device and at the security service are symmetric keys.

Abstract: A cage assembly for a bearing includes a first cage half and a second cage half. The first cage half includes a first annular section with a first plurality of circumferentially spaced apertures for receiving a plurality of rolling elements, and a first cylindrical section arranged for positioning the cage assembly on a first shaft. The second cage half includes a second annular section with a second plurality of circumferentially spaced apertures for receiving the plurality of rolling elements, and a second cylindrical section arranged for positioning the cage assembly on a second shaft. In an example embodiment, the first cylindrical section or the second cylindrical section has an aperture for radial flow of a lubricant.

Abstract: A substrate support system 10 for a conveyor printer is provided, comprising a support unit 100 comprising a plurality of vacuum apertures 108 arranged for fluidic communication with a source of negative pressure. The support unit 100 also comprises at least one air bearing 114 arranged for fluidic communication with a source of positive pressure. The air bearing 114 comprises porous media 116. The substrate support system 10 also comprises a conveyor belt 150 arranged over the support unit 100 for supporting a substrate 170 to be printed on. The conveyor belt 150 comprises a plurality of belt apertures. The vacuum apertures 108 are arranged to convey a negative pressure through the belt apertures for retaining the substrate 170 on the conveyor belt 150. The at least one air bearing 114 is arranged to convey a positive pressure to support the conveyor belt 150.

Abstract: A thrust bearing cage includes a piloting feature to radially locate a thrust bearing with respect to one of the shafts. Specifically, the bearing cage includes an axial extension at an outer diameter that extends beyond the rollers and around an outer diameter of end of the shaft. This feature permits elimination of a washer.

Abstract: According to an embodiment of the present invention, a method, system, and computer program product for preparing a CZ state for use in magic state distillation. The embodiment may include initializing a code state across data qubits. The embodiment may include measuring a CZ operator of the codes state on at least one ancilla qubit proximal to the data qubits. The embodiment may include performing additional quantum operations with the CZ state based on the measurement of the at least one ancilla qubit.

Abstract: A bearing module that supports adjacent ends of coaxial shafts, includes an outer ring having first and second axially adjacent raceways and first and second flanges located at the respective ends. A first group of rolling elements rolls on the first raceway, and a second group of rolling elements rolls on the second raceway. A first cage retains the first group of rolling elements circumferentially spaced apart from one another, and a second cage retains the second group of rolling elements. An axial bearing is retained axially between the first and second groups of rolling elements, and has axial bearing rolling elements that are configured for rolling contact with (a) facing axial side raceways on first and second inner rings supported respectively on the first and second groups of rolling elements, (b) the adjacent ends of the two coaxial shafts, or (c) integral washers of the axial bearing.

Abstract: A method for managing data processes in a network of computing resources includes: receiving at least one child request being routed from an intermediary device to at least one corresponding destination device, the at least one child request requesting execution of at least one corresponding child data process, each of the at least one child data process for executing at least a portion of the at least one parent data process from an instructor device, and each of the at least one child request including a destination key derived at least in part from the at least one instructor key; storing the at least one child request in at least one storage device; modifying the at least one child request upon receiving a child request modification signal; and generating signals for communicating the child requests to one or more requesting devices.

Abstract: A bearing configuration for an oil pump assembly is disclosed herein. The bearing configuration includes a first radially extending hydrodynamic bearing element configured to directly face a first axial side of a gear, a second radially extending hydrodynamic bearing element configured to directly face a second axial side of the gear, and an axially extending hydrodynamic bearing element configured to directly face a radially inner side of the gear. The bearing configuration is configured to be used to support an idler gear in a transmission assembly, in one example.

Abstract: An electro-wetting on dielectric (EWOD) device, comprises first and second substrates defining a fluid chamber therebetween, a plurality of electro-wetting electrodes on the first substrate, and at least one first electrode and at least two second electrodes on the second substrate. The device further includes a current sensor for sensing a difference between (1) a first current flowing between the first electrode and one of the second electrodes via a first fluid package in the fluid chamber of the EWOD device and (2) a second current flowing between the first electrode and another of the second electrodes via a second fluid package in the fluid chamber of the EWOD device.