Patents by Inventor James Brown

James Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200231601
    Abstract: The present disclosure provides a class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, X, R2, R2?, R3, R4, R5, R6, and R7 of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A? plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.
    Type: Application
    Filed: December 13, 2017
    Publication date: July 23, 2020
    Applicant: AMGEN INC.
    Inventors: Jennifer R. ALLEN, Matthew P. BOURBEAU, James A. BROWN, Ning CHEN, Michael J. FROHN, Zice FU, Longbin LIU, Qingyian LIU, Liping H. PETTUS, Wenyuan QIAN, Corey REEVES, Aaron C. SIEGMUND
  • Publication number: 20200228390
    Abstract: Methods, systems, and devices are described for orchestrating server management in a modern IT network. The described techniques may be implemented to manage any number of networked severs, whether local, remote, or both. Server orchestration may leverage a central, cloud-based management system and/or one or more autonomous agents installed on servers with the network. The autonomous agents may each be registered with the supervisory server and may have awareness of one another.
    Type: Application
    Filed: March 26, 2020
    Publication date: July 16, 2020
    Inventors: Rajat Bhargava, James Brown, Christopher Marie
  • Patent number: 10714389
    Abstract: Semiconductor devices and methods to fabricate the devices are provided. For example, a semiconductor device includes a back-end-of-line (BEOL) structure formed on a semiconductor substrate. The BEOL structure further includes at least one metallization layer comprising a pattern of elongated parallel metal lines. The pattern of elongated metal lines comprises a plurality of metal lines having a minimum width and at least one wider metal line having a width which is greater than the minimum width.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: July 14, 2020
    Assignee: ELPIS TECHNOLOGIES, INC.
    Inventors: Hsueh-Chung Chen, James Kelly, Yann Mignot, Cornelius Brown Peethala, Lawrence A. Clevenger
  • Patent number: 10712357
    Abstract: Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: July 14, 2020
    Assignee: Georgia Tech Research Corporation
    Inventors: Edgar A. Brown, James D. Ross, Richard A. Blum, Stephen P. DeWeerth
  • Publication number: 20200220872
    Abstract: Methods, systems, and devices for enterprise-wide management of disparate devices, applications, and users are described. A cloud-based central server may maintain an integrated hosted directory, which may allow user authentication, authorization, and management of information technology (IT) resources across device types, operating systems, and software-as-a-service (SaaS) and. on-premises applications. IT resources for multiple and separate customers may be managed from a single, central directory, and servers may be brought online to allow access to the directory according to system loading.
    Type: Application
    Filed: March 23, 2020
    Publication date: July 9, 2020
    Inventors: Rajat Bhargava, James Brown, Christopher Marie
  • Publication number: 20200219817
    Abstract: Various methods and structures for fabricating BEOL metallization layer including at least one bulk cobalt contact, the at least one bulk cobalt contact including a replacement non-cobalt metal cap integral to the at least one bulk cobalt contact. The method includes performing selective deposition, by a chemical exchange reaction of metal between a non-cobalt metal and Cobalt in the at least one bulk cobalt contact, of the replacement non-cobalt metal cap integrally formed in a top surface region of the bulk cobalt contact.
    Type: Application
    Filed: March 16, 2020
    Publication date: July 9, 2020
    Applicant: International Business Machines Corporation
    Inventors: James J. KELLY, Cornelius Brown PEETHALA
  • Patent number: 10696666
    Abstract: A compound which is an arylimidazolyl isoxazole of formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: June 30, 2020
    Assignee: CELLCENTRIC LIMITED
    Inventors: Neil Anthony Pegg, Stuart Thomas Onions, David Michel Adrien Taddei, Jonathan Shannon, Silvia Paoletta, Richard James Brown, Don Smyth, Gareth Harbottle
  • Patent number: 10695763
    Abstract: A method of extracting assay fluid from an EWOD device, the EWOD device comprising two opposing substrates defining a fluid space there between and an aperture for extraction of fluid from the fluid space. The method comprises providing, in the fluid space of the EWOD device, a droplet of assay fluid adjacent to the aperture such that the droplet blocks extraction, via the aperture, of filler fluid contained in the fluid space of the EWOD device, and extracting, via the aperture, at least some of the assay fluid of the droplet from the fluid space. The method comprises, during the extracting, controlling the assay fluid droplet by electrowetting to maintain the blocking of extraction of filler fluid. By controlling the position of the unextracted portion of the assay fluid droplet relative to the aperture during the extraction process, the unextracted portion of the assay fluid droplet continues to block extraction of filler fluid.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: June 30, 2020
    Assignee: Sharp Life Science (EU) Limited
    Inventors: Emma Jayne Walton, Lesley Anne Parry-Jones, Christopher James Brown
  • Patent number: 10688611
    Abstract: A system and method for using a robotic arm and a part gripping jaw to tend a CNC machine. A robotic arm picks up a part gripping jaw and used the jaw to grip a part, and moves the part into a vise in the CNC machine. The part gripping jaw has features which the vise engages, and secures the part in the part gripping jaw for processing in the CNC machine. The system and method includes a novel racking system, robotic end of arm tool, jaw grippers and vise system. The jaw grippers that hold the part are moved from the rack system, with the part to be processed, by the robot, to the vise where the vise uses the jaw grippers to secure the part for processing. After the part is processed, the robot removes the part from the vise with the jaw grippers and stores the part back into the rack system using the jaw grippers.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: June 23, 2020
    Assignee: VersaBuilt, Inc.
    Inventors: Albert James Youngwerth, Shane Christopher Dittrich, Benjamin Thomas Blaine, Sean Gabriel Brown, Eric James Lebsack
  • Patent number: 10689697
    Abstract: Analysis Of A Polymer A biochemical analysis system analyses polymers by taking measurements of a polymer from a sensor element comprising a nanopore during translocation of the polymer through the nanopore. When a polymer has partially translocated, the series of measurements is analysed using reference data derived from a reference sequence to provide a measure of similarity. Responsive to the measure of similarity, the sensor element may be selectively operated to eject the polymer and thereby make the nanopore available to receive a further polymer. Where the biochemical analysis system comprises an array of sensor elements and is takes measurements from sensor elements selected in a multiplexed manner, responsive to the measure of similarity, the biochemical analysis system ceases taking measurements from the currently selected sensor element and to starts taking measurements from a newly selected sensor element.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: June 23, 2020
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Stuart William Reid, Gavin Harper, Clive Gavin Brown, Daniel John Turner, Andrew John Heron, Christopher James Wright
  • Patent number: 10690017
    Abstract: A hydraulic lash adjuster (HLA) sleeve configured to be received within a lifter bore of an engine block, includes a cylindrical sleeve having an outer surface defining an outer diameter, and an inner surface defining an inner diameter. The outer diameter is sized for an interference fit with the lifter bore to prevent rotation of the HLA sleeve within the lifter bore. The inner diameter is sized to receive a lifter.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: June 23, 2020
    Assignee: Eaton Intelligent Power Limited
    Inventors: Leon Brown, James E. McCarthy, Jr.
  • Publication number: 20200191951
    Abstract: The present invention relates to methods and arrangements for safety monitoring of a safety zone under and in near vicinity around a parked autonomous vehicle before driving, wherein the method comprise acquiring sensor data from an active sensor system located on the undercarriage of the vehicle, wherein the active sensor system is arranged to transmit a signal and receive the signal reflected off objects within the safety zone and store sensor data representative of substantially all of the safety zone, repeatedly building a representation of the safety zone by acquiring sensor data from the active sensor system; iteratively aggregating the representations of the safety zone with a statistical model, and continuously analysing the aggregation of representations and determining if a sensitive object is located within the safety zone of the vehicle.
    Type: Application
    Filed: December 6, 2019
    Publication date: June 18, 2020
    Inventors: Kaice REILLY, James POPLAWSKI, Mark BEELER, Ryan BROWN, Jon D. DEMERLY
  • Patent number: 10683891
    Abstract: A stacked thrust bearing arrangement including a central washer arranged between a first and second bearing assembly is disclosed. The central washer is axially positioned between a first inner bearing ring of the first bearing assembly, and a second inner bearing ring of the second bearing assembly. An inner sleeve defines a first retention flange adapted to engage a first cage of the first bearing assembly, and a second retention flange adapted to engage a second cage of the second bearing assembly.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: June 16, 2020
    Assignee: SCHAEFFLER TECHNOLOGIES AG & CO. KG
    Inventors: Dennis Roffe, James Brown
  • Publication number: 20200182295
    Abstract: A stacked thrust bearing arrangement including a central washer arranged between a first and second bearing assembly is disclosed. The central washer is axially positioned between a first inner bearing ring of the first bearing assembly, and a second inner bearing ring of the second bearing assembly. An inner sleeve defines a first retention flange adapted to engage a first cage of the first bearing assembly, and a second retention flange adapted to engage a second cage of the second bearing assembly.
    Type: Application
    Filed: December 7, 2018
    Publication date: June 11, 2020
    Applicant: Schaeffler Technologies AG & Co. KG
    Inventors: Dennis Roffe, James Brown
  • Publication number: 20200181572
    Abstract: Provided herein are methods of activating immune cells. The method includes providing a population of immune cells and contacting the population of immune cells with a first agent and a second agent. The first agent includes an immune cell activator attached to a first binder moiety, and the second agent includes at least one capture oligomer. The at least one capture oligomer is capable of associating with the first binder moiety. Also provided are kits for activating immune cells.
    Type: Application
    Filed: August 24, 2017
    Publication date: June 11, 2020
    Inventors: Ernest William Kovacs, Anup Sood, Reginald Donovan Smith, Evelina Roxana Loghin, Padmaparna Chaudhuri, Vandana Keskar, Chrystal Mae Chadwick, Martin James Brown
  • Patent number: 10675499
    Abstract: An adjustable weight lifting bench includes a frame, a seat pad, and a back pad. The back pad is pivotably coupled to the frame about a first pivot axis and angularly adjustable between a plurality of user-selectable incline and decline positions. A hydraulic mechanism supports the back pad in the incline and decline positions. A movable operating lever operably coupled to the hydraulic mechanism operates to change the mechanism between an activated condition in which the back pad is movable and a deactivated condition in which the back pad locks into a selected one of the positions. When the mechanism is in activated condition, applying pressure against the back pad the lowers the back pad and removing the pressure raises the back pad. In one embodiment, the mechanism automatically raises the back pad when the pressure is removed and the mechanism is in the deactivated condition.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: June 9, 2020
    Assignee: MAXX BENCH
    Inventors: David Vorozilchak, James J. Lennox, Kenneth Brown, Philip Matthew Hunt
  • Patent number: 10676108
    Abstract: A method of shipping automobiles, railcars for shipping automobiles, and methods of manufacturing railcars for shipping automobiles to enable more efficient shipping of automobiles by facilitating conversion of autorack cars between unilevel, bi-level and tri-level configurations, and/or by providing increased load factors.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: June 9, 2020
    Assignee: Trinity Rail Group, LLC
    Inventors: Robert J. Cencer, Robert C. Ortner, George S. Creighton, Andrew Brown, James R. Mitzenberg
  • Publication number: 20200175522
    Abstract: A method for determining a customer service metric using time-based predictive association based on user interactions over interaction channels. Events associated with intended transaction types are identified as characterized or uncharacterized, and sorted chronologically based on when the event occurred. Sequences of events are created based on analysis of each event against a chronologically consecutive later event and a determination of whether each event is uncharacterized and occurred before the later event and the sequence does not include a characterized event, or, that the earlier event is a characterized event or the sequence includes a characterized event, and the earlier event occurred a period of time before the later event. The later event is appended to a sequence, or an additional sequence is created including the later event, and the sequences are filtered. A customer service metric is determined based on a duration of time calculated for each sequence.
    Type: Application
    Filed: November 29, 2018
    Publication date: June 4, 2020
    Inventors: Xiao Zhang, Vineel Gujjar, James Brown, Shailesh Lahariya, Scott Geller
  • Publication number: 20200175932
    Abstract: An AM-EWOD device includes a plurality of array elements arranged in an array of rows and columns; each column including a column addressing line that applies control signals to a corresponding column of array elements, and each row including a row addressing line that applies control signals to a corresponding row of array elements; each array element including an element electrode for receiving an actuation voltage and a switch transistor, wherein the switch transistor is electrically connected between the column addressing line and the element electrode and is switched by the row addressing line; and a column detection circuit comprising an addressing circuit that applies an electrical perturbation during a sensing operation to the column addressing line of an array element being sensed, and a measuring circuit that measures an output signal from one of the column addressing lines, wherein the output signal varies based upon a capacitance present at the element electrode.
    Type: Application
    Filed: December 3, 2018
    Publication date: June 4, 2020
    Inventors: Benjamin James Hadwen, Oliver James Beard, Christopher James Brown
  • Patent number: D891073
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: July 28, 2020
    Assignee: Allbirds, Inc.
    Inventors: Dennice Quijano Barerra, Timothy Brown, Lisa Halbower-Fenton, James Romero, Talia Rapier, April Gourdie, Jad Finck, Jamie S. McLellan