Patents by Inventor James BRUGAROLAS

James BRUGAROLAS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOMARKERS OF RESPONSE TO HIF-2-ALPHA INHIBITION IN CANCER AND METHODS FOR THE USE THEREOF
    Publication number: 20210222257
    Abstract: Described herein are methods and systems for identifying and/or treating subjects having cancer who are more likely to respond to treatment with an inhibitor of the transcription factor HIF-2?.
    Type: Application
    Filed: March 19, 2021
    Publication date: July 22, 2021
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Min Soo KIM, James BRUGAROLAS, Tae Hyun HWANG, Yang XIE
  • PET RADIOPHARMACEUTICALS FOR NON-INVASIVE EVALUATION OF HIF-2alpha
    Publication number: 20210190788
    Abstract: Provided herein are hypoxia inducible factor 2-alpha (HIF-2?)-specific radioactive tracers, methods of use thereof, and methods of synthesis thereof. Specifically, provided herein are HIF-2?-specific radioactive tracers comprising an HIF-2?-specific agent developed as a therapeutic inhibitor and a positron emitting radioactive label. Embodiments provide methods of detecting an HIF-2?-expressing tumor, detecting an HIF-2? inhibitor resistant tumor, evaluating a change in HIF-2? expression in response to an anti-cancer treatment, detecting acquisition of HIF-2? inhibitor resistance, evaluating efficacy of an HIF-2? depletion therapy, or detecting or monitoring an ischemic area in a subject. Also provided are methods of synthesizing an HIF-2?-specific radioactive tracer.
    Type: Application
    Filed: December 21, 2020
    Publication date: June 24, 2021
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: James BRUGAROLAS, Xiankai SUN, Sashi DEBNATH
  • PET RADIOPHARMACEUTICALS FOR NON-INVASIVE EVALUATION OF HIF-2alpha
    Publication number: 20210187130
    Abstract: Provided herein are hypoxia inducible factor 2-alpha (HIF-2?)-specific radioactive tracers, methods of use thereof, and methods of synthesis thereof. Specifically, provided herein are HIF-2?-specific radioactive tracers comprising an HIF-2?-specific agent developed as a therapeutic inhibitor and a positron emitting radioactive label. Embodiments provide methods of detecting an HIF-2?-expressing tumor, detecting an HIF-2? inhibitor resistant tumor, evaluating a change in HIF-2? expression in response to an anti-cancer treatment, detecting acquisition of HIF-2? inhibitor resistance, evaluating efficacy of an HIF-2? depletion therapy, detecting or monitoring an ischemic area in a subject, or detecting and monitoring pulmonary hypertension in a subject. Also provided are methods of synthesizing an HIF-2?-specific radioactive tracer.
    Type: Application
    Filed: January 20, 2021
    Publication date: June 24, 2021
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: James BRUGAROLAS, Xiankai SUN, Sashi DEBNATH
  • BIOMARKERS OF RESPONSE TO HIF-2-ALPHA INHIBITION IN CANCER AND METHODS FOR THE USE THEREOF
    Publication number: 20190048421
    Abstract: Described herein are methods and systems for identifying and/or treating subjects having cancer who are more likely to respond to treatment with an inhibitor of the transcription factor HIF-2?.
    Type: Application
    Filed: September 16, 2016
    Publication date: February 14, 2019
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Min Soo KIM, James BRUGAROLAS, Tae Hyun HWANG, Yang XIE