Patents by Inventor James Bubien

James Bubien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of inward sodium currents in cancer
    Publication number: 20070092444
    Abstract: Described is a constitutive inward Na+ currents found in a variety of human cancers. The constitutive inward Na+ current plays a role in increased cellular proliferation, cellular migration and volume regulation. The inward current is mediated, at least in part, by AISC-containing Na+ channels. In addition, an inhibitor of the inward current, the PcTX1 peptide, is described. Also provided are methods for screening compounds to inhibit the inward Na+ current, methods for screening for tumors expressing the inward Na+ current and methods for treating tumors expressing the inward Na+ current.
    Type: Application
    Filed: September 13, 2004
    Publication date: April 26, 2007
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventors: Dale Benos, James Bubien, G. Gillespie