Abstract: The present application discloses a method of shaping a working material (12) into an article, consisting of two primary stages: (a) in the absence of added heat, consolidating and shaping the working material into a pre-form shape using a dynamic hydroforming process that employs a rigid, male-shaped tool (32) and a non-rigid, female-shaped tool (23, 24, 26); and (b) in the presence of added heat, further consolidating and shaping the working material into the final shape using at least one additional rigid forming tool (50).

Abstract: Gadgets integrate with spreadsheets and the spreadsheet calculation engine. A gadget is bound to a range of cells (one or more) within a sheet. When one or more of the cells of the bound range is accessed (e.g. selected, hovered over, edited, deleted, added), the gadget is notified. The gadget may use this information for updating a display rendered by the gadget and/or performing some other action. The gadget uses an Application Programming Interface (API) to create the binding, communicate with the spreadsheet, and perform actions in the spreadsheet. The gadget is a Named Item object within the spreadsheet such that the gadget may be viewed/displayed differently from other objects. Out of date requests from the gadget are attempted to be detected and prevented from being processed such that the gadget is not acting on the latest data.

Abstract: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, among others.

Abstract: Described herein are intracameral implants including at least one therapeutic agent for treatment of at least one ocular condition. The implants described herein are not anchored to the ocular tissue, but rather are held in place by currents and gravity present in the anterior chamber of an eye. The implants are preferably polymeric, biodegradable and provide sustained release of at least one therapeutic agent to both the trabecular meshwork and associated ocular tissue and the fluids within the anterior chamber of an eye.

Abstract: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.

Abstract: A user interface provides historical and hierarchical search and navigation modes through previously selected and hierarchically linked multimedia applications, documents and directories. The system permits a search for information through hierarchically linked documents accessible via the Internet in which an individual document contains a reference link to a succeeding document. The systems includes an input processor for receiving a user entered search information item identifying an object associated with at least one of the hierarchically linked documents. An Internet processor for searching and identifying a plurality of child documents hierarchically linked to a parent document identified by the object and excluding non-hierarchically associated documents in response to user initiation of a hierarchical search. An output processor processes data identifying the plurality of child documents for communication to a reproduction device.

Abstract: A drug delivery system (DDS) comprised of segmented biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The segmented implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer, and permit the DDS to have segments that possess individual and different drug release characteristics.

Abstract: Described herein are intracameral implants including at least one therapeutic agent for treatment of at least one ocular condition. The implants described herein are not anchored to the ocular tissue, but rather are held in place by currents and gravity present in the anterior chamber of an eye. The implants are preferably polymeric, biodegradable and provide sustained release of at least one therapeutic agent to both the trabecular meshwork and associated ocular tissue and the fluids within the anterior chamber of an eye.

Abstract: Gadgets integrate with spreadsheets and the spreadsheet calculation engine. A gadget is bound to a range of cells (one or more) within a sheet. When one or more of the cells of the bound range is accessed (e.g. selected, hovered over, edited, deleted, added), the gadget is notified. The gadget may use this information for updating a display rendered by the gadget and/or performing some other action. The gadget uses an Application Programming Interface (API) to create the binding, communicate with the spreadsheet, and perform actions in the spreadsheet. The gadget is a Named Item object within the spreadsheet such that the gadget may be viewed/displayed differently from other objects. Out of date requests from the gadget are attempted to be detected and prevented from being processed such that the gadget is not acting on the latest data.

Abstract: The present invention provides a sustained release implant for intraocular use to treat elevated intraocular pressure, which implant is configured for intracameral or anterior vitreal administration to a patient with elevated intraocular pressure (IOP), said implant comprising a core of an antihypertensive agent surrounded by a polymer, which limits the rate of passage of the antihypertensive agent from the implant into the eye of said patient and said implant provides a linear rate of release of therapeutically effective amounts of said anti-hypertensive agent into the eye for a period of time of between 14 days and 365 days.

Abstract: A drug delivery system (DDS) comprised of segmented biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The segmented implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer, and permit the DDS to have segments that possess individual and different drug release characteristics.

Abstract: The present invention provides method and apparatus for treating tissue in a region at depth by applying optical radiation thereto of a wavelength able to reach the depth of the region and of a selected relatively low power for a duration sufficient for the radiation to effect the desired treatment while concurrently cooling tissue above the selected region to protect such tissue. Treatment may be enhanced by applying mechanical, acoustic or electrical stimulation to the region.

Abstract: A clothing style selection display image includes, first and second windows enabling a user to select a top dress item and a bottom dress item respectively and a match zone. The match zone presents a selected top dress item and a bottom dress item adjacent, in response to user selection of the selected top dress item and the selected bottom dress item in the first and second windows respectively. In a clothing style selection and matching game embodiment, the display image presents an indicator of degree of match of dress items in the match zone with a winner having best match. In another game embodiment, the display image presents multiple different match zones with a winner matching dress items in the multiple different match zones fastest. The match zone presents the selected top dress item and the bottom dress item with substantially matching waist size.

Abstract: A system and method are provided for secure network communications. A proxy server receives meter data, from a meter of a set of meters via a local network, for an energy management server. The proxy server uses secure communications to send the meter data via a non-secure network to the energy management server.

Abstract: Compositions and methods for treating dry age related macular degeneration (dry AMO) by administration to an intraocular location of an anti-neovascular agent (such as bevacizumab) in either a liquid or solid polymeric vehicle (or both), such as a biodegradable hyaluronic acid or PLGA (or PLA).

Abstract: Compositions and methods for treating dry age related macular degeneration (dry AMD) by administration to an intraocular location of an anti-neovascular agent (such as bevacizumab) in either a liquid or solid polymeric vehicle (or both), such as a biodegradable hyaluronic acid or PLGA (or PLA).

Abstract: An engine cranking system and a method of cranking an engine are provided. The engine cranking system comprises an engine, cranking motor, and capacitor. The engine cranking system further comprises an electrical path interconnecting the cranking motor or a battery to the capacitor. The engine cranking system further comprises a control circuit coupled to the capacitor. The control circuit comprises a timer operative to track temporal information. The control circuit is operative to apply a control voltage that varies in response to the tracked temporal information. The control circuit further comprises a relay included in the electrical path. The relay is operative to switch, in response to the control voltage, between an open-circuit condition, in which the relay interrupts the electrical path, and a closed-circuit condition.

Abstract: Biodegradable drug delivery systems, such as extruded implants, for the sustained delivery of a protein to an ocular region of the eye or intraarticular region in the body are described. The drug delivery systems may be used to treat a variety of ocular and medical conditions, including macular degeneration. Methods for using and making the drug delivery systems are also described. The drug delivery systems can be in the form of extruded filaments configured for placement in an ocular region such as the vitreous body or anterior chamber of the eye.

Abstract: Described herein are intracameral implants including at least one therapeutic agent for treatment of at least one ocular condition. The implants described herein are not anchored to the ocular tissue, but rather are held in place by currents and gravity present in the anterior chamber of an eye. The implants are preferably polymeric, biodegradable and provide sustained release of at least one therapeutic agent to both the trabecular meshwork and associated ocular tissue and the fluids within the anterior chamber of an eye.

Abstract: Described herein are intracameral implants including at least one therapeutic agent for treatment of at least one ocular condition. The implants described herein are not anchored to the ocular tissue, but rather are held in place by currents and gravity present in the anterior chamber of an eye. The implants are preferably polymeric, biodegradable and provide sustained release of at least one therapeutic agent to both the trabecular meshwork and associated ocular tissue and the fluids within the anterior chamber of an eye.