Abstract: Various devices, methods, and systems to implant and secure a fusion cage or intervertebral prosthesis during treatment of spinal injury or disease are provided. In various embodiments, such devices may comprise an instrument assembly having a body comprising a head, a shaft, and a handle; an insertion stop; and an intervertebral device retainer. Various embodiments also may comprise an impactor assembly comprising a housing; a bit comprising a head, a shaft, and a coupler; a transmission comprising a housing, a cam, a cam follower, a collet, and a driveshaft; and the motor. In various embodiments, the impactor assembly may be deployed with adjustments for the frequency, displacement, and force of impulses delivered to an anchor for the intervertebral device.

Abstract: Various devices, methods, and systems to implant and secure a fusion cage or intervertebral prosthesis during treatment of spinal injury or disease are provided. In various embodiments, such devices may comprise an instrument assembly having a body comprising a head, a shaft, and a handle; an insertion stop; and an intervertebral device retainer. Various embodiments also may comprise an impactor assembly comprising a housing; a bit comprising a head, a shaft, and a coupler; a transmission comprising a housing, a cam, a cam follower, a collet, and a driveshaft; and the motor. In various embodiments, the impactor assembly may be deployed with adjustments for the frequency, displacement, and force of impulses delivered to an anchor for the intervertebral device.

Abstract: Various devices, methods, and systems to implant and secure a fusion cage or intervertebral prosthesis during treatment of spinal injury or disease are provided. In various embodiments, such devices may comprise an instrument assembly having a body comprising a head, a shaft, and a handle; an insertion stop; and an intervertebral device retainer. Various embodiments also may comprise an impactor assembly comprising a housing; a bit comprising a head, a shaft, and a coupler; a transmission comprising a housing, a cam, a cam follower, a collet, and a driveshaft; and the motor. In various embodiments, the impactor assembly may be deployed with adjustments for the frequency, displacement, and force of impulses delivered to an anchor for the intervertebral device.

Abstract: According to embodiments of the present invention, a dishwasher may include a manifold assembly including a manifold and an attachment assembly. The manifold may provide a fluid connection with a fluid supply and direct fluid from the fluid supply to a spray device. The attachment assembly may couple the manifold to a dish rack. Further, the attachment assembly may facilitate movement of the dish rack relative to the manifold between a retracted position and an extended position while maintaining the fluid connection with the fluid supply. The attachment assembly may include at least one sliding rail and a first plurality of engagement members that couple the sliding rail to the dish rack. Additionally, a second plurality of engagement members may couple the manifold and the sliding rail so as to allow movement along the sliding rail along a major axis of the sliding rail.

Abstract: According to embodiments of the present invention, a dishwasher may include a manifold assembly including a manifold and an attachment assembly. The manifold may provide a fluid connection with a fluid supply and direct fluid from the fluid supply to a spray device. The attachment assembly may couple the manifold to a dish rack. Further, the attachment assembly may facilitate movement of the dish rack relative to the manifold between a retracted position and an extended position while maintaining the fluid connection with the fluid supply. The attachment assembly may include at least one sliding rail and a first plurality of engagement members that couple the sliding rail to the dish rack. Additionally, a second plurality of engagement members may couple the manifold and the sliding rail so as to allow movement along the sliding rail along a major axis of the sliding rail.

Abstract: A drain valve for a dishwasher and associated apparatus and method are provided. A housing receives fluid through an inlet channel and channels the fluid toward an outlet channel extending from an outlet port defined by the housing. A sealing member is disposed within the housing and is capable of forming a sealing engagement with the outlet port. A cradle member disposed within the housing is configured to receive and partially constrain freedom of movement of the sealing member. The cradle member is movable between a valve closed position, where fluid flow toward the outlet channel urges the sealing member into sealing engagement with the outlet port to close the drain valve, and a valve open position, where fluid flow is allowed between the inlet channel and the outlet channel, through the housing, without the sealing member engaging the outlet port.

Abstract: Described is a method of modulating the activation of a Rho, Arf, Rab, Ran or Rap family protein, said method comprising administering to said sample a USP-17 modulator, for example an inhibitor of expression or activity of DUB-3. The invention enables the use of USP-17 modulators in the treatment of metastatic cancer and other conditions.

Abstract: A drain valve for a dishwasher and associated apparatus and method are provided. A housing receives fluid through an inlet channel and channels the fluid toward an outlet channel extending from an outlet port defined by the housing. A sealing member is disposed within the housing and is capable of forming a sealing engagement with the outlet port. A cradle member disposed within the housing is configured to receive and partially constrain freedom of movement of the sealing member. The cradle member is movable between a valve closed position, where fluid flow toward the outlet channel urges the sealing member into sealing engagement with the outlet port to close the drain valve, and a valve open position, where fluid flow is allowed between the inlet channel and the outlet channel, through the housing, without the sealing member engaging the outlet port.

Abstract: A tubular manifold device for a dishwasher and associated method are provided. The manifold device defines a contiguous interior channel between opposed inlet and outlet ends. The manifold device has an inner surface defining the interior channel and an opposing outer surface, and comprises at least two discretely-formed manifold portions, each extending between and at least bisecting the opposed inlet and outlet ends of the interior channel. The at least two manifold portions are capable of cooperating via respective engagable longitudinal edges so as to form at least two joints therebetween. At least one overmold member is configured to sealingly engage the at least two manifold portions, across each of the at least two joints, such that the interior channel is fluid-tight between the inlet and outlet ends.

Abstract: A boring tool moves having a pitch orientation, a yaw orientation and a roll orientation and is steerable underground using the roll orientation. A maximum drill string curvature is established for steering. The boring tool is advanced over a path segment. An averaged roll characteristic is determined for movement of the boring tool along the path segment. A path segment pitch orientation is established based on at least one measured pitch orientation along the path segment. Using the maximum drill string curvature in combination with the averaged roll characteristic and the path segment pitch orientation, the yaw orientation is determined. The averaged roll characteristic is determined based on a series of incremental roll measurements that are spaced across the path segment. A set of coupled ordinary differential equations is used to characterize movement of the boring tool.

Abstract: A tubular manifold device for a dishwasher and associated method are provided. The manifold device defines a contiguous interior channel between opposed inlet and outlet ends. The manifold device has an inner surface defining the interior channel and an opposing outer surface, and comprises at least two discretely-formed manifold portions, each extending between and at least bisecting the opposed inlet and outlet ends of the interior channel. The at least two manifold portions are capable of cooperating via respective engagable longitudinal edges so as to form at least two joints therebetween. At least one overmold member is configured to sealingly engage the at least two manifold portions, across each of the at least two joints, such that the interior channel is fluid-tight between the inlet and outlet ends.

Abstract: Described is a novel human deubiquitinating enzyme, DUB-3, (SEQ ID NO: 1), and variants and fragments thereof. Also described are nucleic acid molecules encoding the enzyme, and use of the polypeptide and nucleic acid molecules in treatment of cancer, assays.

Abstract: A boring tool moves having a pitch orientation, a yaw orientation and a roll orientation and is steerable underground using the roll orientation. A maximum drill string curvature is established for steering. The boring tool is advanced over a path segment. An averaged roll characteristic is determined for movement of the boring tool along the path segment. A path segment pitch orientation is established based on at least one measured pitch orientation along the path segment. Using the maximum drill string curvature in combination with the averaged roll characteristic and the path segment pitch orientation, the yaw orientation is determined. The averaged roll characteristic is determined based on a series of incremental roll measurements that are spaced across the path segment. A set of coupled ordinary differential equations is used to characterize movement of the boring tool.

Abstract: Methods and apparatus for manipulating separation media in the context of filling one or more capillaries with a separation medium for electrophoresis. A polymer-displacement pump system and method for reciprocating a pump piston in a first direction to draw fresh fluid into a chamber, and reciprocating the pump piston in a second direction to cause the fresh fluid to exit the chamber and fill a single capillary or multi-capillary array. The pump piston movement can be electrically controlled.

Abstract: A boring tool moves having a pitch orientation, a yaw orientation and a roll orientation and is steerable underground using the roll orientation. A maximum drill string curvature is established for steering. The boring tool is advanced over a path segment. An averaged roll characteristic is determined for movement of the boring tool along the path segment. A path segment pitch orientation is established based on at least one measured pitch orientation along the path segment. Using the maximum drill string curvature in combination with the averaged roll characteristic and the path segment pitch orientation, the yaw orientation is determined. The averaged roll characteristic is determined based on a series of incremental roll measurements that are spaced across the path segment. A set of coupled ordinary differential equations is used to characterize movement of the boring tool.

Abstract: A machine for producing corrugated board which utilizes a dual thermal sensing system to determine the length of the web is disclosed. The corrugating machine includes a frame through which a web material is adapted to be traversed, an applicator adapted to apply a liquid spot, such as water, to the web, and first and second temperature sensors adapted to detect the liquid spot after the liquid spot is applied.

Abstract: An implantable orthopedic prosthesis has a macro/micro-textured bone and soft tissue attachment surface to which a spiked washer is clamped by a threaded bolt received through said washer and threaded into said prosthesis. Soft tissue is secured to the prosthesis by clamping between said washer and said soft tissue attachment surface. The tissue attachment surface is arranged as a regular grid of depressions separated by orthogonal ridges formed by electrodischarge machining of the prosthesis using a machining electrode having a mold-opposite surface texture with a micro-textured roughened surface finish. The spacing of the spikes is and integer multiple of the spacing of the depressions to assure registry of the spikes with the depressions.