Patents by Inventor James Bustillo

James Bustillo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHEMICAL SENSOR WITH CONSISTENT SENSOR SURFACE AREAS
    Publication number: 20140264472
    Abstract: In one embodiment, a chemical sensor is described. The chemical sensor includes a chemically-sensitive field effect transistor including a floating gate conductor having an upper surface. A material defines an opening extending to the upper surface of the floating gate conductor, the material comprising a first dielectric underlying a second dielectric. A conductive element contacts the upper surface of the floating gate conductor and extending a distance along a sidewall of the opening.
    Type: Application
    Filed: March 5, 2014
    Publication date: September 18, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Keith G. FIFE, Jordan OWENS, Shifeng LI, James BUSTILLO
  • CHEMICAL SENSOR WITH PROTRUDED SENSOR SURFACE
    Publication number: 20140264322
    Abstract: In one implementation, a chemical sensor is described. The chemical sensor includes a chemically-sensitive field effect transistor including a floating gate conductor having an upper surface. A conductive element protrudes from the upper surface of the floating gate conductor into an opening. A dielectric material defines a reaction region. The reaction region overlies and extends below an upper surface of the conductive element.
    Type: Application
    Filed: March 5, 2014
    Publication date: September 18, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Keith G. FIFE, Jordan OWENS, Shifeng LI, James BUSTILLO
  • CHEMICAL DEVICE WITH THIN CONDUCTIVE ELEMENT
    Publication number: 20140264471
    Abstract: In one implementation, a chemical device is described. The sensor includes a chemically-sensitive field effect transistor including a floating gate structure having a plurality of floating gate conductors electrically coupled to one another. A conductive element overlies and is in communication with an uppermost floating gate conductor in the plurality of floating gate conductors. The conductive element is wider and thinner than the uppermost floating gate conductor. A dielectric material defines an opening extending to an upper surface of the conductive element.
    Type: Application
    Filed: March 5, 2014
    Publication date: September 18, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Keith G. FIFE, Jordan OWENS, Shifeng LI, James BUSTILLO
  • CHEMICAL SENSORS WITH PARTIALLY EXTENDED SENSOR SURFACES
    Publication number: 20140264465
    Abstract: In one implementation, a chemical sensor is described. The chemical sensor includes a chemically-sensitive field effect transistor including a floating gate conductor having an upper surface. A dielectric material defines an opening extending to the upper surface of the floating gate conductor. A conductive element is on a sidewall of the opening and spaced away from an upper surface of the dielectric material, the conductive element communicating with the floating gate conductor.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 18, 2014
    Applicant: Life Technologies Corporation
    Inventors: Keith Fife, James Bustillo, Jordan Owens
  • CHEMICAL SENSOR WITH SIDEWALL SPACER SENSOR SURFACE
    Publication number: 20140264464
    Abstract: In one implementation, a chemical sensor is described. The chemical sensor includes chemically-sensitive field effect transistor including a floating gate conductor having an upper surface. A dielectric material defines an opening extending to the upper surface of the floating gate conductor. A conductive sidewall spacer is on a sidewall of the opening and contacts the upper surface of the floating gate conductor.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 18, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Keith G. FIFE, James BUSTILLO, Jordan OWENS
  • METHODS FOR MANUFACTURING CHEMICAL SENSORS WITH EXTENDED SENSOR SURFACES
    Publication number: 20140273324
    Abstract: In one implementation, a method for manufacturing a chemical sensor is described. The method includes forming a chemically-sensitive field effect transistor including a floating gate conductor having an upper surface. A dielectric material is formed defining an opening extending to the upper surface of the floating gate conductor. A conductive material is formed within the opening and on an upper surface of the dielectric material. A fill material is formed on the conductive material. The fill material is used as a protect mask to remove the conductive material on the upper surface of the dielectric material. The fill material is then removed to expose remaining conductive material on a sidewall of the opening.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 18, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Keith G. Fife, James Bustillo, Jordan Owens
  • Titanium nitride as sensing layer for microwell structure
    Patent number: 8821798
    Abstract: A method of fabricating a microwell in an array structure is disclosed herein. The array structure can include a plurality of field effect transistors (FETs), where each FET has a gate structure. The method can include disposing a titanium nitride (TiN) layer on at least one conductive layer coupled to the gate structure of at least one FET. A insulation layer can also be disposed on the array structure, where the insulation layer lies above the TiN layer. Further, an opening above the gate structure of the at least one FET can be etched to remove the insulation layer above the gate structure and to expose the TiN layer. A microwell with at least one sidewall formed from the insulation layer and with a bottom surface formed from the TiN layer is a result of the etching process.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: September 2, 2014
    Assignee: Life Technologies Corporation
    Inventors: James Bustillo, Todd Rearick, Wolfgang Hinz, Keith Fife
  • ELECTRIC FIELD DIRECTED LOADING OF MICROWELL ARRAY
    Publication number: 20140217477
    Abstract: An apparatus includes a device substrate including an array of sensors. Each sensor of the array of sensors can include a electrode structure disposed at a surface of the device substrate. The apparatus further includes a wall structure overlying the surface of the device substrate and defining an array of wells at least partially corresponding with the array of sensors. The well structure including an electrode layer and an insulative layer.
    Type: Application
    Filed: April 3, 2014
    Publication date: August 7, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Kristopher BARBEE, John F. DAVIDSON, Wolfgang HINZ, Shifeng LI, James BUSTILLO
  • CHEMICAL SENSOR WITH CONDUCTIVE CUP-SHAPED SENSOR SURFACE
    Publication number: 20140220697
    Abstract: A system includes a sensor including a sensor pad and a well wall structure defining a well operatively coupled to the sensor pad. The well is further defined by a lower surface disposed over the sensor pad. The well wall structure defines an upper surface and defines a wall surface extending between the upper surface and the lower surface. The system further includes a conductive layer disposed over the lower surface and the wall surface.
    Type: Application
    Filed: April 24, 2014
    Publication date: August 7, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Shifeng LI, James BUSTILLO, Wolfgang HINZ
  • METHODS FOR MANUFACTURING WELL STRUCTURES FOR LOW-NOISE CHEMICAL SENSORS
    Publication number: 20140191293
    Abstract: In one implementation, a method for manufacturing a chemical detection device is described. The method includes forming a chemical sensor having a sensing surface. A dielectric material is deposited on the sensing surface. A first etch process is performed to partially etch the dielectric material to define an opening over the sensing surface and leave remaining dielectric material on the sensing surface. An etch protect material is formed on a sidewall of the opening. A second etch process is then performed to selectively etch the remaining dielectric material using the etch protect material as an etch mask, thereby exposing the sensing surface.
    Type: Application
    Filed: January 8, 2013
    Publication date: July 10, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: James BUSTILLO, Shifeng LI
  • Methods for operating chemically sensitive sensors with sample and hold capacitors
    Patent number: 8764969
    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: July 1, 2014
    Assignee: Life Technologies Corporation
    Inventors: Jonathan Rothberg, Wolfgang Hinz, Kim Johnson, James Bustillo
  • Chemically-sensitive sample and hold sensors
    Patent number: 8766328
    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: July 1, 2014
    Assignee: Life Technologies Corporation
    Inventors: Jonathan M. Rothberg, Wolfgang Hinz, Kim L. Johnson, James Bustillo
  • Chemical sensor with conductive cup-shaped sensor surface
    Patent number: 8747748
    Abstract: A system includes a sensor including a sensor pad and a well wall structure defining a well operatively coupled to the sensor pad. The well is further defined by a lower surface disposed over the sensor pad. The well wall structure defines an upper surface and defines a wall surface extending between the upper surface and the lower surface. The system further includes a conductive layer disposed over the lower surface and the wall surface.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: June 10, 2014
    Assignee: Life Technologies Corporation
    Inventors: Shifeng Li, James Bustillo, Wolfgang Hinz
  • Chemically sensitive sensors with sample and hold capacitors
    Patent number: 8742472
    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: June 3, 2014
    Assignee: Life Technologies Corporation
    Inventors: Jonathan M. Rothberg, Wolfgang Hinz, Kim L. Johnson, James Bustillo
  • Chemical Coating of Microwell for Electrochemical Detection Device
    Publication number: 20140113303
    Abstract: The described embodiments may provide a method of fabricating a chemical detection device. The method may comprise forming a microwell above a CMOS device. The microwell may comprise a bottom surface and sidewalls. The method may further comprise applying a first chemical to be selectively attached to the bottom surface of the microwell, forming a metal oxide layer on the sidewalls of the microwell, and applying a second chemical to be selectively attached to the sidewalls of the microwell. The second chemical may lack an affinity to the first chemical.
    Type: Application
    Filed: December 23, 2013
    Publication date: April 24, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Wolfgang HINZ, John M. MAURO, Shifeng LI, James BUSTILLO
  • Chemical sensor array having multiple sensors per well
    Patent number: 8692298
    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: April 8, 2014
    Assignee: Life Technologies Corporation
    Inventors: Jonathan M. Rothberg, Wolfgang Hinz, Kim L. Johnson, James Bustillo
  • Methods and apparatus for high-speed operation of a chemically-sensitive sensor array
    Patent number: 8685230
    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.
    Type: Grant
    Filed: July 24, 2012
    Date of Patent: April 1, 2014
    Assignee: Life Technologies Corporation
    Inventors: Jonathan Rothberg, Wolfgang Hinz, Kim Johnson, James Bustillo
  • Methods for operating an array of chemically-sensitive sensors
    Patent number: 8658017
    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: February 25, 2014
    Assignee: Life Technologies Corporation
    Inventors: Jonathan Rothberg, Wolfgang Hinz, Kim Johnson, James Bustillo
  • Chemical coating of microwell for electrochemical detection device
    Patent number: 8647577
    Abstract: The described embodiments may provide a method of fabricating a chemical detection device. The method may comprise forming a microwell above a CMOS device. The microwell may comprise a bottom surface and sidewalls. The method may further comprise applying a first chemical to be selectively attached to the bottom surface of the microwell, forming a metal oxide layer on the sidewalls of the microwell, and applying a second chemical to be selectively attached to the sidewalls of the microwell. The second chemical may lack an affinity to the first chemical.
    Type: Grant
    Filed: October 10, 2012
    Date of Patent: February 11, 2014
    Assignee: Life Technologies Corporation
    Inventors: Wolfgang Hinz, John Matthew Mauro, Shifeng Li, James Bustillo
  • METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS
    Publication number: 20130324421
    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in the concentration of inorganic pyrophosphate (PPi), hydrogen ions, and nucleotide triphosphates.
    Type: Application
    Filed: August 13, 2013
    Publication date: December 5, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Jonathan M. ROTHBERG, Wolfgang HINZ, Kim L. JOHNSON, James BUSTILLO, John LEAMON, Jonathan SCHULTZ