Patents by Inventor James BUTTON

James BUTTON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phage display library, members thereof and uses of the same
    Patent number: 10829540
    Abstract: The present invention relates to a library (in particular a phage display library) from which an improved human antibody having greater specificity and potency for its target may be generated; and to methods of generating such a human antibody. In particular, the invention relates to a human antibodies against challenging targets obtainable from such a library and which have HCDR3s of at least 18 amino acids in length.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: November 10, 2020
    Assignee: Medimmune Limited
    Inventors: Tristan Vaughan, David Lowe, Stacey Chin, Benjamin David Grimshaw, James Button
  • P2X4 ANTIBODIES & USES THEREOF
    Publication number: 20200247885
    Abstract: The invention provides antibodies that specifically bind a P2X4 polypeptide and modulate P2X4 channel activity, recombinant P2X4 polypeptides and methods for generating such polypeptides, as well as compositions and methods for generating anti-P2X4 antibodies, and methods of using P2X4 antibodies for the treatment of neuropathic pain and other indications.
    Type: Application
    Filed: April 6, 2020
    Publication date: August 6, 2020
    Inventors: Wendy A. WILLIAMS, Clare JONES, James BUTTON, John LINLEY, Harm Jan SNIJDER, Ling HUANG, Yoko SHIBATA, Sudharsan SRIDHARAN, Maria GROVES, Claire DOBSON
  • P2X4 antibodies and uses thereof
    Patent number: 10654926
    Abstract: The invention provides antibodies that specifically bind a P2X4 polypeptide and modulate P2X4 channel activity, recombinant P2X4 polypeptides and methods for generating such polypeptides, as well as compositions and methods for generating anti-P2X4 antibodies, and methods of using P2X4 antibodies for the treatment of neuropathic pain and other indications.
    Type: Grant
    Filed: May 2, 2015
    Date of Patent: May 19, 2020
    Assignee: MedImmune Limited
    Inventors: Wendy A Williams, Clare Jones, James Button, John Linley, Harm Jan Snijder, Ling Huang, Yoko Shibata, Sudharsan Sridharan, Maria Groves, Claire Dobson
  • NOVEL PHAGE DISPLAY LIBRARY, MEMBERS THEREOF AND USES OF THE SAME
    Publication number: 20180155409
    Abstract: The present invention relates to a library (in particular a phage display library) from which an improved human antibody having greater specificity and potency for its target may be generated; and to methods of generating such a human antibody. In particular, the invention relates to a human antibodies against challenging targets obtainable from such a library and which have HCDR3s of at least 18 amino acids in length.
    Type: Application
    Filed: April 29, 2016
    Publication date: June 7, 2018
    Inventors: Tristan VAUGHAN, David LOWE, Stacey CHIN, Benjamin David GRIMSHAW, James BUTTON
  • ION CHANNEL MODULATORS AND USES THEREOF
    Publication number: 20170166634
    Abstract: The invention provides antibodies that specifically bind a P2X4 polypeptide and modulate P2X4 channel activity, recombinant P2X4 polypeptides and methods for generating such polypeptides, as well as compositions and methods for generating anti-P2X4 antibodies, and methods of using P2X4 antibodies for the treatment of neuropathic pain and other indications.
    Type: Application
    Filed: May 2, 2015
    Publication date: June 15, 2017
    Applicant: Medimmune Limited
    Inventors: Wendy A WILLIAMS, Clare JONES, James BUTTON, John LINLEY, Harm Jan SNIJDER, Ling HUANG, Yoko SHIBATA, Sudharsan SRIDHARAN, Maria GROVES, Claire DOBSON