Abstract: The present invention relates to a library (in particular a phage display library) from which an improved human antibody having greater specificity and potency for its target may be generated; and to methods of generating such a human antibody. In particular, the invention relates to a human antibodies against challenging targets obtainable from such a library and which have HCDR3s of at least 18 amino acids in length.

Abstract: The invention provides antibodies that specifically bind a P2X4 polypeptide and modulate P2X4 channel activity, recombinant P2X4 polypeptides and methods for generating such polypeptides, as well as compositions and methods for generating anti-P2X4 antibodies, and methods of using P2X4 antibodies for the treatment of neuropathic pain and other indications.

Abstract: The invention provides antibodies that specifically bind a P2X4 polypeptide and modulate P2X4 channel activity, recombinant P2X4 polypeptides and methods for generating such polypeptides, as well as compositions and methods for generating anti-P2X4 antibodies, and methods of using P2X4 antibodies for the treatment of neuropathic pain and other indications.

Abstract: The present invention relates to a library (in particular a phage display library) from which an improved human antibody having greater specificity and potency for its target may be generated; and to methods of generating such a human antibody. In particular, the invention relates to a human antibodies against challenging targets obtainable from such a library and which have HCDR3s of at least 18 amino acids in length.

Abstract: The invention provides antibodies that specifically bind a P2X4 polypeptide and modulate P2X4 channel activity, recombinant P2X4 polypeptides and methods for generating such polypeptides, as well as compositions and methods for generating anti-P2X4 antibodies, and methods of using P2X4 antibodies for the treatment of neuropathic pain and other indications.

Abstract: Systems and methods for determining user specific information and knowledge relevancy, relevant knowledge and information discovery, user intent and relevant interactions via intelligent messaging, collaboration, sharing and information categorization, further delivering created knowledge accessible through a personalized user experience.

Abstract: Light diffusing optical fibers and methods for producing light diffusing optical fibers are disclosed. In one embodiment, a light diffusing optical fiber includes a core portion formed from silica glass and comprising a plurality of helical void randomly distributed in the core portion of the optical fiber and wrapped around the long axis of the optical fiber. A pitch of the helical voids may vary along the axial length of the light diffusing optical fiber in order to achieve the desired illumination along the length of the optical fiber. A cladding may surround the core portion. Light guided by the core portion is scattered by the helical voids radially outward, through the cladding, such that the light diffusing optical fiber emits light with a predetermined intensity over an axial length of the light diffusing optical fiber, the light diffusing optical fiber having a scattering induced attenuation loss greater than about 0.2 dB/m at a wavelength of 550 nm.

Abstract: Light diffusing optical fibers and methods for producing light diffusing optical fibers are disclosed. In one embodiment, a light diffusing optical fiber includes a core portion formed from silica glass and comprising a plurality of helical void randomly distributed in the core portion of the optical fiber and wrapped around the long axis of the optical fiber. A pitch of the helical voids may vary along the axial length of the light diffusing optical fiber in order to achieve the desired illumination along the length of the optical fiber. A cladding may surround the core portion. Light guided by the core portion is scattered by the helical voids radially outward, through the cladding, such that the light diffusing optical fiber emits light with a predetermined intensity over an axial length of the light diffusing optical fiber, the light diffusing optical fiber having a scattering induced attenuation loss greater than about 0.2 dB/m at a wavelength of 550 nm.

Abstract: Systems and methods for determining user specific information and knowledge relevancy, relevant knowledge and information discovery, user intent and relevant interactions via intelligent messaging, collaboration, sharing and information categorisation, further delivering created knowledge accessible through a personalised user experience.

Abstract: A multi-amplification path optical amplifier including a first amplification path for propagating and amplifying a first in-band optical communication signal, including a spectrally selective filter for substantially blocking the propagation and amplification of an out-of-band optical communication signal along the first amplification path, and a second amplification path for propagating and amplifying a second in-band optical communication signal, including a spectrally selective filter for substantially blocking the propagation and amplification of an out-of-band optical communication signal along the second amplification path, wherein the location. If the spectrally selective filters in each respective amplification path is selected so that a target noise figure performance and a target output power performance can be obtained from the device. The spectrally selective insertion losses suppress crosstalk or optical leakage that gives rise to multipath interference, return loss, and self oscillation.

Abstract: A multi-amplification path optical amplifier including a first amplification path for propagating and amplifying a first in-band optical communication signal, including a spectrally selective filter for substantially blocking the propagation and amplification of an out-of-band optical communication signal along the first amplification path, and a second amplification path for propagating and amplifying a second in-band optical communication signal, including a spectrally selective filter for substantially blocking the propagation and amplification of an out-of-band optical communication signal along the second amplification path, wherein the location of the spectrally selective filters in each respective amplification path is selected so that a target noise figure performance and a target output power performance can be obtained from the device. The spectrally selective insertion losses suppress crosstalk or optical leakage that gives rise to multipath interference, return loss, and self oscillation.