Abstract: A novel oral pharmaceutical composition in the form of a stable flocculated suspension in water is described as comprising: megestrol acetate; at least one compound selected from the group consisting of polyethylene glycol, propylene glycol, glycerol, and sorbitol; and a surfactant, wherein polysorbate and polyethylene glycol are not simultaneously present.

Abstract: A novel oral pharmaceutical composition in the form of a stable flocculated suspension in water is described as comprising: megestrol acetate; at least one compound selected from the group consisting of polyethylene glycol, propylene glycol, glycerol, and sorbitol; and a surfactant, wherein polysorbate and polyethylene glycol are not simultaneously present.

Abstract: A novel oral pharmaceutical composition in the form of a stable flocculated suspension in water is described as comprising: megestrol acetate; at least one compound selected from the group consisting of polyethylene glycol, propylene glycol, glycerol, and sorbitol; and a surfactant, wherein polysorbate and polyethylene glycol are not simultaneously present.

Abstract: A novel oral pharmaceutical composition in the form of a stable flocculated suspension in water is described as comprising: megestrol acetate; at least one compound selected from the group consisting of polyethylene glycol, propylene glycol, glycerol, and sorbitol; and a surfactant, wherein polysorbate and polyethylene glycol are not simultaneously present.

Abstract: A novel oral pharmaceutical composition in the form of a stable flocculated suspension in water is described as comprising: megestrol acetate; at least one compound selected from the group consisting of polyethylene glycol, propylene glycol, glycerol, and sorbitol; and a surfactant, wherein polysorbate and polyethylene glycol are not simultaneously present.

Abstract: A novel oral pharmaceutical composition in the form of a stable flocculated suspension in water is described as comprising: megestrol acetate; at least one compound selected from the group consisting of polyethylene glycol, propylene glycol, glycerol, and sorbitol; and a surfactant, wherein polysorbate and polyethylene glycol are not simultaneously present.

Abstract: A process for condensing vapor or mist material onto a thin first liquid film surface, which liquid film is generated and supported on the outer surface of a porous structure. A moving condensable vapor contacts the thin liquid film and is condensed onto the liquid surface. The condensed vapor drains by gravity action into a collection zone, together with a portion of the liquid film material being entrained therein. The vapor or mist material can be either substantially immiscible or miscible in the liquid film. The first liquid is preferably provided in a closed system and is recycled at near ambient temperature and at pressure conditions sufficient to produce the thin liquid film external to the porous structure, which has a porosity of 20-80%. An apparatus including the porous structure and liquid handling system for condensing an upflowing condensable vapor is disclosed.

Abstract: Monosaccharides, such as glucose-water solution, are catalytically hydrogenated by being passed through multiple reaction zones connected in series and each containing a high-activity supported nickel catalyst to produce 99.8 W % overall conversion to an alditol solution such as sorbitol. The pH of liquid in each reaction zone is controlled to between 4.5 and 7 by adding an alkali solution such as sodium hydroxide to the feed to prevent acid leaching of catalyst metal and to help maintain catalyst activity therein. Reaction zone conditions used are 130.degree.-180.degree. C. temperature, 500-2000 psig hydrogen partial pressure, and a ratio of hydrogen gas/feed liquid within the range of about 500-5000. Feedstream liquid space velocity is maintained within range of 0.5-16 V.sub.f /Hr/V.sub.c, with higher space velocities being used for achieving lower incremental conversion desired in the subsequent reaction zones to help maintain pH of the effluent liquid within the desired range.

Abstract: Alditols such as 15-40 W. % sorbitol solution in water are catalytically hydrocracked in a fixed bed reaction process using a high activity nickel catalyst to produce at least about 30 W. % conversion to glycerol and glycol products. The feedstream pH is controlled to prevent catalyst damage by adding a basic promotor material such as calcium hydroxide. Reaction zone conditions are maintained at 420.degree.-520.degree. F. temperature, 1200-2000 psig hydrogen partial pressure, and liquid hourly space velocity of 1.5 to 3.0. To maintain desired activity and glycerol yield, the catalyst is regenerated to provide catalyst age of 8-200 hours. The reaction products are separated in a recovery step, and any alditols can be recycled to the reaction zone for further hydrogenolysis to produce 40-90 W. % glycerol product. Sorbitol conversion is maintained preferably at between about 30-70 W.

Abstract: Organic liquid-water solutions, such as 5-30 W % alcohol in water, are separated efficiently in a two-stage adsorption process using a bed of selected adsorbent material in each stage to produce a concentrated organic product. Each adsorbent is selected to effectively adsorb the minor component from the feed solution and thus provide a dehydrated alcohol product. In the first-stage adsorber bed, activated carbon is used to selectively adsorb the alcohol, after which the desorbed alcohol vapor is passed to a second-stage adsorber bed of molecular sieve adsorbent for virtually complete removal of the remaining water. The process provides a dehydrated alcohol liquid product preferably containing less than about 2 W % water, and requires low energy usage.

Abstract: Monosaccharides such as glucose solution are catalytically hydrogenated in fixed bed reaction process using a high activity nickel catalyst to produce at least about 98 W % conversion to sorbitol solution. The feedstream pH is controlled to between 7 and 13 by adding a basic solution such as sodium hydroxide. Reaction zone conditions are 500-2000 psig hydrogen partial pressure, 130.degree.-180.degree. C. temperature, and use a ratio of hydrogen gas/feed liquid within the range of 1000-5000. Feedstream liquid space velocity is within range of 0.5-3.5 Vf/Hr/Vc.