Patents by Inventor James C. Chen

James C. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10307610
    Abstract: A prostate treatment system having a light delivery device positionable in a transurethral device for treatment of benign prostatic hyperplasia (BPH). The light delivery device includes light generator, such as light emitting diodes (LED), laser diodes (LDs) or a diffusion quartz fiber tip connected to a light generator or a light emitting polymer which produces light at a selected wavelength or waveband or alternative sources of suitable light energy. The treatment device may further include a temperature monitoring system for monitoring the temperature at the treatment site. A light-activated drug is administered to the treatment site prior to light activation. The light-activated drug therapy induces cell death of the target tissue. The device provides a minimally invasive transurethral method for treatment of BPH or prostate cancer.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: June 4, 2019
    Assignee: LIGHT SCIENCES ONCOLOGY INC.
    Inventors: Llew Keltner, Jay Winship, Erik Hagstrom, Frank Zheng, James C. Chen, Joseph M. Hobbs
  • Publication number: 20170246472
    Abstract: Systems, devices, and methods are described for providing, among other things, improvement in treatment of abnormal tissues including cancer, utilizing light activated drug therapy. Improvements include the use of optical penetration and drug penetration enhancers, in combination with photosensitizing drugs, and the use of localization aids and implements, which enable treatment of larger tissue volumes using minimal tissue access. The cytotoxic photoactivation process is also improved by using internal guidance to direct the light source to and at the lesion site using a naturally occurring orifice or intravascular access route.
    Type: Application
    Filed: September 8, 2015
    Publication date: August 31, 2017
    Inventors: James C. CHEN, Llew KELTNER, Alexei N. NAIMUSHIN
  • Publication number: 20170128741
    Abstract: A prostate treatment system having a light delivery device positionable in a transurethral device for treatment of benign prostatic hyperplasia (BPH). The light delivery device includes light generator, such as light emitting diodes (LED), laser diodes (LDs) or a diffusion quartz fiber tip connected to a light generator or a light emitting polymer which produces light at a selected wavelength or waveband or alternative sources of suitable light energy. The treatment device may further include a temperature monitoring system for monitoring the temperature at the treatment site. A light-activated drug is administered to the treatment site prior to light activation. The light-activated drug therapy induces cell death of the target tissue. The device provides a minimally invasive transurethral method for treatment of BPH or prostate cancer.
    Type: Application
    Filed: January 13, 2017
    Publication date: May 11, 2017
    Applicant: Purdue Pharmaceutical Products L.P.
    Inventors: Llew KELTNER, Jay WINSHIP, Erik HAGSTROM, Frank ZHENG, James C. CHEN, Joseph M. HOBBS
  • Publication number: 20160213945
    Abstract: A photoreactive agent and a drug therapy device including a support member configured to pass through a urethra having proximal and distal ends and a longitudinal internal lumen. A light generator carried by the support member, potted within the lumen, and positioned within the urethra to deliver light to the prostate. The light generator generates a light band with a peak at a preselected wavelength. A power source external to the support member powers the light generator. The positioning element locates the support member within the urethra. A transparent/translucent, integral window is positioned proximate to the prostate and allows light to pass through. The window extends 360 degrees radially from the support member. The light generator has at least LEDs or LOs having a dimension of approximately 0.3 mm×0.3 mm×0.1 mm (length×width×thickness).
    Type: Application
    Filed: April 5, 2016
    Publication date: July 28, 2016
    Applicant: PURDUE PHARMACEUTICAL PRODUCTS L.P.
    Inventors: Phillip Burwell, Zihong Guo, Jennifer K. Matson, Steven Ross Daly, David B. Shine, Gary Lichttenegger, Jean Bishop, Nick Yeo, Hugh Narciso, Llew Keltner, Jay Winship, Erik Hagstrom, Frank Zheng, James C. Chen, Joseph M. Hobbs
  • Patent number: 9149651
    Abstract: An energy treatment system to treat a patient includes an energy delivery device having a plurality of energy emitters used in combination with an energy activatable drug. A mask can be used to define a treatment area. Energy from the energy emitters passes through an optical window of the mask to activate a cosmetically and/or therapeutically effective amount of the activatable drug at the target site to bring about a desired change of tissue, for example, to reduce visibility of one or more blood vessels, while energy from the energy emitters directed outside of the target site is blocked by the mask.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: October 6, 2015
    Assignee: PURDUE PHARMACEUTICAL PRODUCTS L.P.
    Inventors: Llew Keltner, James C. Chen
  • Patent number: 8685005
    Abstract: A light delivery system to provide light treatment to a patient includes a catheter assembly having a plurality of light sources that transmit light towards a target site within a patient. In one embodiment, the light delivery system has a plurality of light sources mounted to a flexible transparent base that extends at least partially through a distal tip of the catheter assembly. The light sources can be wire bonded or mounted in a flip chip arrangement onto the base. In one embodiment to produce the distal tip, an array of light energy sources can be held by an array of holders of a fixture device. A vacuum is applied to secure each light energy source in a corresponding holder. While the vacuum is applied, the energy sources are electrically connected by wire bonding. The vacuum can be reduced or stopped thereby permitting removal of the light energy sources from the fixture device.
    Type: Grant
    Filed: October 11, 2007
    Date of Patent: April 1, 2014
    Assignee: Purdue Pharmaceutical Products L.P.
    Inventors: Jonathan S. Dahm, William Louis Barnard, James C. Chen, David B. Shine
  • Patent number: 8685071
    Abstract: A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: April 1, 2014
    Assignee: Purdue Pharmaceutical Products L.P.
    Inventors: Phillip Burwell, James C. Chen, Zihong Guo, Steven R. Daly, David B. Shine, Gary Lichttenegger, Jennifer K. Matson, Jean Bishop, Nick Yeo, Hugh Narciso
  • Publication number: 20120209359
    Abstract: A light delivery system to provide light treatment to a patient includes an elongated catheter having a light emitter that transmits light towards a target site within a patient. The catheter is sized and configured to pass through anatomical body structures to reduce or eliminate trauma associated with the delivery procedure. A visualization system of the catheter can assist a user before, during, and/or after performing light therapy. The visualization system includes sensors that provide real-time imaging or feedback.
    Type: Application
    Filed: August 13, 2010
    Publication date: August 16, 2012
    Applicant: Light Sciences Oncology Inc.
    Inventors: James C. Chen, William L. Barnard, David B. Shine, Jay Miazga
  • Patent number: 8235975
    Abstract: A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: August 7, 2012
    Assignee: Light Sciences Oncology, Inc.
    Inventors: James C. Chen, Steven R. Daly, Zihong Guo, Llew Keltner, Jeffrey R. Storm
  • Publication number: 20120149986
    Abstract: A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
    Type: Application
    Filed: February 21, 2012
    Publication date: June 14, 2012
    Applicant: Light Sciences Oncology, Inc.
    Inventors: Phillip Burwell, James C. Chen, Zihong Guo, Steven R. Daly, David B. Shine, Gary Lichtlenegger, Jennifer K. Matson, Jean Bishop, Nick YEO, Hugh Narciso
  • Publication number: 20120149091
    Abstract: Systems, devices, and methods for cultivating biomasses. A bioreactor system is operable for growing photosynthetic organisms. The bioreactor system includes a bioreactor and a lighting system. The lighting system includes one more light-emitting substrates configured to light at least some of a plurality of photosynthetic organisms retained in the bioreactor.
    Type: Application
    Filed: December 8, 2006
    Publication date: June 14, 2012
    Inventors: Brian D. Wilkerson, James C. Chen, John Pulse, Andrei Guschin, Michael Weaver
  • Publication number: 20120089207
    Abstract: A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
    Type: Application
    Filed: October 14, 2011
    Publication date: April 12, 2012
    Applicant: Light Sciences Oncology, Inc.
    Inventors: James C. Chen, Steven R. Daly, Zihong Guo, Llew Keltner, Jeffrey R. Storm
  • Patent number: 8097028
    Abstract: The present invention provides a prophylactic light activated treatment method for subjects at risk of a plaque-mediated thrombotic event, such as acute coronary syndromes. In one embodiment, the subject receives a dose of photosensitizer sufficient to result in a concentration of photosensitizer in the neovascularization associated with atherosclerotic disease to permit effective photodynamic therapy. Light of a wavelength that excites the photosensitizer, but that does not to any significant extent penetrate to an adventitial layer of the blood vessel, is applied to the region of the blood vessel. The therapeutic light dose, which may be applied in sequential stages, is sufficient to cause closure of neovasculature leakage and lead to plaque stabilization and reduced adverse clinical outcomes. The present invention further provides light transmission devices and systems useful in carrying out the methods of the present invention.
    Type: Grant
    Filed: February 17, 2006
    Date of Patent: January 17, 2012
    Assignee: Light Sciences Oncology, Inc.
    Inventors: James C. Chen, Nicholas Yeo, Phillip Burwell, Thomas Wenger
  • Patent number: 8057464
    Abstract: A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: November 15, 2011
    Assignee: Light Sciences Oncology, Inc.
    Inventors: James C. Chen, Steven R. Daly, Zihong Guo, Llew Keltner, Jeffrey R. Storm
  • Publication number: 20110236402
    Abstract: The efficacy of light activated therapy treatment is enhanced by stimulating the immune system of the patient substantially above a normal level. Abnormal tissue that is destroyed by the light activated therapy releases factors that stimulate the immune system, leading to systemic reductions in abnormal tissue (i.e., reduction beyond the region treated using light). By further stimulating the immune system using an anti-CTLA-4 antibody, the systemic destruction of abnormal tissue is enhanced.
    Type: Application
    Filed: June 6, 2011
    Publication date: September 29, 2011
    Applicant: Light Sciences Oncology, Inc.
    Inventor: James C. Chen
  • Patent number: 7993640
    Abstract: The efficacy of light activated therapy treatment is enhanced by stimulating the immune system of the patient substantially above a normal level. Abnormal tissue that is destroyed by the light activated therapy releases factors that stimulate the immune system, leading to systemic reductions in abnormal tissue (i.e., reduction beyond the region treated using light). By further stimulating the immune system using an anti-CTLA-4 antibody, the systemic destruction of abnormal tissue is enhanced.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: August 9, 2011
    Assignee: Light Sciences Oncology, Inc.
    Inventor: James C. Chen
  • Publication number: 20110077464
    Abstract: A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
    Type: Application
    Filed: September 24, 2010
    Publication date: March 31, 2011
    Applicant: Light Sciences Oncology, Inc.
    Inventors: Phillip Burwell, James C. Chen, Zihong Guo, Steven R. Daly, David B. Shine, Gary Lichttenegger, Jennifer K. Matson, Jean Bishop, Nick Yeo, Hugh Narciso
  • Patent number: 7873744
    Abstract: System and computer program product are provided to configure a path between nodes through a fabric in a fibre channel storage area network (SAN). A node name is provided for a target node on the SAN and a port name is provided for each port in the target node. A relationship is established in a data structure between each port name and a slot in which each port is physically located in the target node. Prior to configuring a path between a source node and a port in the target node, the ports which are physically connected and logged in to the fabric are identified by port address. The port names corresponding to the port addresses are then identified. The port names are used to generate interface_ids of the ports corresponding to the physical slots in which the ports are located. A data structure is created to maintain the relationship between interface_ids and port names.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: January 18, 2011
    Assignee: International Business Machines Corporation
    Inventors: James C. Chen, Patricia C. Lu, Chung M. Fung, Minh-Ngoc L. Huynh, Christopher M. Sansone, Dung N. Dang, Gail A. Spear, Richard A. Ripberger
  • Patent number: RE46504
    Abstract: A light delivery system to provide light treatment to a patient includes a catheter assembly having a plurality of light sources that transmit light towards a target site within a patient. In one embodiment, the light delivery system has a plurality of light sources mounted to a flexible transparent base that extends at least partially through a distal tip of the catheter assembly. The light sources can be wire bonded or mounted in a flip chip arrangement onto the base. In one embodiment to produce the distal tip, an array of light energy sources can be held by an array of holders of a fixture device. A vacuum is applied to secure each light energy source in a corresponding holder. While the vacuum is applied, the energy sources are electrically connected by wire bonding. The vacuum can be reduced or stopped thereby permitting removal of the light energy sources from the fixture device.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: August 8, 2017
    Assignee: PURDUE PHARMACEUTICAL PRODUCTS L.P.
    Inventors: Jonathan S. Dahm, William Louis Barnard, James C. Chen, David B. Shine
  • Patent number: RE47491
    Abstract: A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: July 9, 2019
    Assignee: LIGHT SCIENCES ONCOLOGY, INC.
    Inventors: James C. Chen, Steven R. Daly, Zihong Guo, Llew Keltner, Jeffrey R. Storm