Abstract: An antifuse circuit includes a terminal, an antifuse, and a select transistor. The antifuse is coupled to the terminal and has an associated program voltage. The select transistor is coupled to the antifuse and has a gate terminal coupled to receive a first select signal. The select transistor operates in a snapback mode of operation in response to an assertion of the first select signal and the program voltage at the terminal.

Abstract: A process of treating a woven fabric by applying to the fabric a viscous polymer in a 5 to 40 wt % solution with a solvent, wherein the polymer has a Tg in the range of about minus 40 to about 0° C. and a zero shear melt viscosity of about 2×106 to about 1013 poise when measured at 20° C. and then evaporating the solvent such that the polymer only partially penetrates the fabric and penetrates to in and between fiber bundles before the polymer solidifies.

Abstract: The invention provides compositions and methods for storage of biomolecules. The biomolecules are stored via absorption to a substrate. Absorbed biomolecules can be eluted or recovered from the substrate at a future time, and optionally be subjected to a subsequent analysis or application. Biomolecules absorbed to a substrate for storage may also optionally be preserved, i.e., the absorbed biomolecule is resistant to or resists degradation.

Abstract: The present invention provides compositions and methods for efficient recovery of nucleic acids, in particular DNA, from storage media. The present invention provides a method for using an alkaline elution buffer and mechanical agitation to elute nucleic acids from dried samples on storage media at room temperature. In particular, the present invention provides a method for room temperature recovery of DNA, including double stranded DNA (dsDNA) and single stranded (ssDNA), from storage media.

Abstract: A system and method operative in accordance with the present disclosure facilitate storage and retrieval of individual or discrete samples of biological, non-biological, and chemical material stored on dry media. Sample material may be disposed upon or within a porous or solid (i.e., non-porous) sample storage medium and subsequently archived in, and retrieved from, storage elements such as multi-well plates, for example, using robotic devices or other automated apparatus. The disclosed system and method enable ejection of sample material from a sealed storage element into a specific well of a multi-well daughter plate, or into a specific cuvette, test tube, or similar container. In some embodiments, a sample carrier comprising a storage medium may be punched or ejected through a first seal of the storage element with an apparatus or implement such as a disposable piercing tip, for instance, inserted through a second seal of the storage element.

Abstract: The invention provides coding compositions comprising mixtures of coding oligonucleotides and methods of using such compositions to code samples. The compositions and methods are useful for identifying, verifying, or authenticating any type of sample, whether the sample is biological or non-biological.

Abstract: The invention provides compositions and methods for storage of biomolecules. The biomolecules are stored via absorption to a substrate. Absorbed biomolecules can be eluted or recovered from the substrate at a future time, and optionally be subjected to a subsequent analysis or application. Biomolecules absorbed to a substrate for storage may also optionally be preserved, i.e., the absorbed biomolecule is resistant to or resists degradation.

Abstract: This invention relates to methods for rapid nucleic acid purification from sources heavily contaminated with high particulate material, such as cellular debris, and solids, including suspended solids. In particular, this invention provides methods for rapid, quantifiable recovery and purification of nucleic acids from a variety of sources heavily contaminated with solids, such as small organisms, tissue samples, samples of blood found on soil, or samples of washing from foods, which are frequently difficult sources for nucleic acid isolation due to their propensity to clog filters and columns. A device and kit are also provided.

Abstract: An antifuse circuit includes a terminal, an antifuse, and a select transistor. The antifuse is coupled to the terminal and has an associated program voltage. The select transistor is coupled to the antifuse and has a gate terminal coupled to receive a first select signal. The select transistor operates in a snapback mode of operation in response to an assertion of the first select signal and the program voltage at the terminal.

Abstract: The invention relates to methods, a kit, and an apparatus for detecting and analyzing genetic material from a biological sample. The method can be used to analyze samples from a wide variety of sources, including tissues, blood, plasma, sera, mucus, urine, saliva, sweat, semen, and cultures, as well as analyzing samples of contaminated water, food, beverages, and other items.

Abstract: A system and method operative in accordance with the present disclosure facilitate storage and retrieval of individual or discrete samples of biological, non-biological, and chemical material stored on dry media. Sample material may be disposed upon or within a porous or solid (i.e., non-porous) sample storage medium and subsequently archived in, and retrieved from, storage elements such as multi-well plates, for example, using robotic devices or other automated apparatus. The disclosed system and method enable ejection of sample material from a sealed storage element into a specific well of a multi-well daughter plate, or into a specific cuvette, test tube, or similar container. In some embodiments, a sample carrier comprising a storage medium may be punched or ejected through a first seal of the storage element with an apparatus or implement such as a disposable piercing tip, for instance, inserted through a second seal of the storage element.

Abstract: A medium for storage and subsequent analysis of a genetic material includes a support for immobilizing the genetic material thereon and allowing subsequent elution of the genetic material therefrom and a coating functionally associated with the support for enabling cellular lysis and releasing the genetic material from the lysed cells while stabilizing the immobilized released genetic material. A method of storing the genetic material and subsequently analyzing the genetic material includes the steps of immobilizing the genetic material on a support while enabling cellular lysis and release of genetic material from the lysed cells and stabilizing the immobilized released genetic material on the support. The genetic material is then eluted to generate a soluble genetic material fraction. The eluted genetic material can be analyzed.

Abstract: This invention relates to methods for rapid nucleic acid purification from sources heavily contaminated with high particulate material, such as cellular debris, and solids, including suspended solids. In particular, this invention provides methods for rapid, quantifiable recovery and purification of nucleic acids from a variety of sources heavily contaminated with solids, such as small organisms, tissue samples, samples of blood found on soil, or samples of washing from foods, which are frequently difficult sources for nucleic acid isolation due to their propensity to clog filters and columns. A device and kit are also provided.

Abstract: The system provides true two integration of web provided data into a practice management system. The system builds a web site on a host system and transmits input data from the web site to a remote computer system. The input data is any information provided by a patient to the web site. Additionally, the host system receives display data from a remote computer system. Each practice or remote system provides the display data for its patients. The display data typically consists of patient account information. When a web site receives a request from a patient, the host system retrieves that individuals data for display on the web site.

Abstract: The invention relates to methods, a kit, and an apparatus for detecting and analyzing genetic material from a biological sample. The method can be used to analyze samples from a wide variety of sources, including tissues, blood, plasma, sera, mucus, urine, saliva, sweat, semen, and cultures, as well as analyzing samples of contaminated water, food, beverages, and other items.

Abstract: According to the present invention, there is provided a multiwell device including a multiwell plate having at least one well, wherein each well has an open end portion and a sealing mechanism disposed over each well. The sealing mechanism prevents the loss of contents from each well after the sealing mechanism receives and is penetrated by a material transfer device during a material transfer procedure. Additionally, the present invention provides for a sealing mechanism for being disposed over a plurality of wells of a multiwell plate. The sealing mechanism prevents loss of content from the wells during a material transfer procedure. The present invention also provides for a method of transferring material from the wells of the multiwell device including the steps of puncturing the sealing matrix with the material transfer device and preventing cross-contamination of the content with other wells.

Abstract: A substrate processing apparatus having a supply of substrates, a substrate transport module, and a substrate processing module. The transport module has a movable arm assembly and two substrate holders mounted to the movable arm assembly. The substrate holders each have two separate holding areas for simultaneously holding two substrates. The movable arm assembly has two pairs of driven arms. Each pair of driven arms is connected to a separate one of the holders for extending and retracting the holders along a radial path relative to a center of the movable arm assembly.