Patents by Inventor James C. Geoghegan

James C. Geoghegan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods to Increase or Decrease Bone Density
    Publication number: 20110009467
    Abstract: The SOST gene gives rise to sclerostin, a protein that leads to apoptosis of bone progenitor cells. The invention provides antagonists to the sclerostin protein, and methods for identifying new sclerostin antagonists. The invention also provides molecules that can depress expression of the SOST gene, as well as methods for identifying such molecules. Such molecules and antagonists are useful for increasing bone mineralization in mammals, for example, in the treatment of osteoporosis.
    Type: Application
    Filed: February 2, 2010
    Publication date: January 13, 2011
    Applicant: CELLTECH R & D, INC.
    Inventors: Mary S. Kung Sutherland, James C. Geoghegan, John Latham, Changpu Yu
  • Methods to Increase or Decrease Bone Density
    Publication number: 20080227138
    Abstract: The SOST gene gives rise to sclerostin, a protein that leads to apoptosis of bone progenitor cells. The invention provides antagonists to the sclerostin protein, and methods for identifying new sclerostin antagonists. The invention also provides molecules that can depress expression of the SOST gene, as well as methods for identifying such molecules. Such molecules and antagonists are useful for increasing bone mineralization in mammals, for example, in the treatment of osteoporosis.
    Type: Application
    Filed: December 19, 2007
    Publication date: September 18, 2008
    Applicant: CELLTECH R & D, INC.
    Inventors: May S. Kung Sutherland, James C. Geoghegan, John Latham, Changpu Yu
  • Methods to increase or decrease bone density
    Patent number: 7332276
    Abstract: The SOST gene gives rise to sclerostin, a protein that leads to apoptosis of bone progenitor cells. The invention provides antagonists to the sclerostin protein, and methods for identifying new sclerostin antagonists. The invention also provides molecules that can depress expression of the SOST gene, as well as methods for identifying such molecules. Such molecules and antagonists are useful for increasing bone mineralization in mammals, for example, in the treatment of osteoporosis.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: February 19, 2008
    Assignee: Celltech R&D, Inc.
    Inventors: May S. Kung Sutherland, James C. Geoghegan, John Latham, Changpu Yu
  • Methods to increase or decrease bone density
    Publication number: 20030229041
    Abstract: The SOST gene gives rise to sclerostin, a protein that leads to apoptosis of bone progenitor cells. The invention provides antagonists to the sclerostin protein, and methods for identifying new sclerostin antagonists. The invention also provides molecules that can depress expression of the SOST gene, as well as methods for identifying such molecules. Such molecules and antagonists are useful for increasing bone mineralization in mammals, for example, in the treatment of osteoporosis.
    Type: Application
    Filed: February 28, 2003
    Publication date: December 11, 2003
    Inventors: May S. Kung Sutherland, James C. Geoghegan, John Latham, Changpu Yu