Patents by Inventor James C. Keith

James C. Keith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenyl substituted thiophenes as estrogenic agents
    Publication number: 20030199570
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: January 10, 2003
    Publication date: October 23, 2003
    Inventors: Richard D. Coghlan, William F. Fobare, Heather A. Harris, James C. Keith, Leo M. Albert
  • Substituted benzoxazoles as estrogenic agents
    Publication number: 20030199562
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 4, 2002
    Publication date: October 23, 2003
    Applicant: Wyeth
    Inventors: Michael S. Malamas, Robert E. McDevitt, Iwan Gunawan, Eric S. Manas, Michael D. Collini, Heather A. Harris, James C. Keith, Leo M. Albert, C. Richard Lyttle
  • Substituted phenyl naphthalenes as estrogenic agents
    Publication number: 20030181519
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 11, 2002
    Publication date: September 25, 2003
    Applicant: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Cuijian Yang, Heather A. Harris, James C. Keith, Leo M. Albert
  • Substituted 6H-DiBenzo[c,h]chromenes as estrogenic agents
    Publication number: 20030176491
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 11, 2002
    Publication date: September 18, 2003
    Applicant: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Stephen T. Cohn, Heather A. Harris, James C. Keith, Leo M. Albert
  • Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents
    Publication number: 20030171412
    Abstract: This invention provides estrogen receptor modulators of formula 1, having the structure 1
    Type: Application
    Filed: December 11, 2002
    Publication date: September 11, 2003
    Applicant: Wyeth
    Inventors: Michael S. Malamas, Iwan Gunawan, Heather A. Harris, James C. Keith, Leo M. Albert
  • Substituted 2-phenyl benzofurans as estrogenic agents
    Publication number: 20030171428
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 16, 2002
    Publication date: September 11, 2003
    Applicant: Wyeth
    Inventors: Christopher P. Miller, Michael D. Collini, David H. Kaufman, Robert L. Morris, Robert R. Singhaus, John W. Ullrich, Heather A. Harris, James C. Keith, Leo M. Albert, Rayomand J. Unwalla
  • Substituted indenones as estrogenic agents
    Publication number: 20030166643
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 11, 2002
    Publication date: September 4, 2003
    Applicant: Wyeth
    Inventors: Robert E. McDevitt, Folake O. Adebi, Heather A. Harris, James C. Keith, Leo M. Albert
  • 6-Hydroxyequilenins as estrogenic agents
    Publication number: 20030166627
    Abstract: This invention provides estrogen receptor modulators of formula 1, having the structure 1
    Type: Application
    Filed: January 21, 2003
    Publication date: September 4, 2003
    Applicant: Wyeth
    Inventors: Heather A. Harris, James C. Keith, Leo M. Albert, Galina Vid, Sreenivasulu Megati, Christopher P. Miller
  • Methods of preventing immune-mediated abortion by inhibiting a CD28-mediated costimulatory signal
    Patent number: 6613327
    Abstract: Methods of inhibiting and diagnosing spontaneous abortion in a subject are provided. The subject methods are based, inter alia, on the administration of an agent that inhibits a CD28-C mediated costimulatory signal in a T cell such that spontaneous abortion in the subject is inhibited. The subject methods are also based on the levels of adhesion molecules, inflammatory cytokines, and immune cell surface molecules which are altered in spontaneous abortion.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: September 2, 2003
    Assignee: Genetics Institute, Inc.
    Inventors: Vincent Ling, Gary S. Gray, James C. Keith, Srinivas Maganti
  • Topical formulations for delivery of interleukin-11
    Publication number: 20030147849
    Abstract: Provided by the present invention are topical formulations of Interleukin-11 and methods for treating a variety of disorders, including inflammatory bowel diseases (e.g., Crohn's disease, ulcerative colitis, indeterminate colitis, and infectious colitis), mucositis (e.g., oral mucositis, gastrointestinal mucositis, nasal mucositis, and proctitis), necrotizing enterocolitis, inflammatory skin disorders (e.g., psoriasis, atopic dermatitis, and contact hypersensitivity), aphthous ulcers, pharyngitis, esophagitis, peptic ulcers, gingivitis, periodontitis, and ocular diseases (e.g., conjunctivitis, retinitis, and uveitis).
    Type: Application
    Filed: February 7, 2003
    Publication date: August 7, 2003
    Applicant: Wyeth
    Inventors: Nicholas W. Warne, Camille L. Bedrosian, James C. Keith, Ullrich S. Schwerschlag, Paul F. Schendel
  • Substituted 10,11-benzo[b]fluoren-10-ones as estrogenic agents
    Patent number: 6589980
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein X, Y1, Y2, Y3, Y4, Z1, Z2, Z3, and Z4 are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: July 8, 2003
    Assignee: Wyeth
    Inventors: Christopher P. Miller, Michael D. Collini, Heather A. Harris, James C. Keith, Jr.
  • Substituted 10,11-benzo[b]fluoren-10-ones as estrogenic agents
    Publication number: 20030087955
    Abstract: This invention provides estrogen receptor modulators of formula 1, having the structure 1
    Type: Application
    Filed: May 15, 2002
    Publication date: May 8, 2003
    Applicant: Wyeth
    Inventors: Christopher P. Miller, Michael D. Collini, Heather A. Harris, James C. Keith
  • 5, 11-Dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents
    Patent number: 6559177
    Abstract: This invention provides estrogen receptor modulators of formula 1, having the structure wherein X, Y1, Y2, Y3, Y4, Z1, Z2, Z3, and Z4 are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: May 6, 2003
    Assignee: Wyeth
    Inventors: Christopher P. Miller, Michael D. Collini, Heather A. Harris, James C. Keith, Jr.
  • Method of treating inflammatory bowel disease using a topical formulation of IL-11
    Patent number: 6540993
    Abstract: Provided by the present invention are topical formulations of Interleukin-11 and methods for treating a variety of disorders, including inflammatory bowel diseases (e.g., Crohn's disease, ulcerative colitis, indeterminate colitis, and infectious colitis), mucositis (e.g., oral mucositis, gastrointestinal mucositis, nasal mucositis, and proctitis), necrotizing enterocolitis, inflammatory skin disorders (e.g., psoriasis, atopic dermatitis, and contact hypersensitivity), aphthous ulcers, pharyngitis, esophagitis, peptic ulcers, gingivitis, periodontitis, and ocular diseases (e.g., conjunctivitis, retinitis, and uveitis).
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: April 1, 2003
    Assignee: Wyeth
    Inventors: Nicholas W. Warne, Camille L. Bedrosian, James C. Keith, Jr., Ullrich S. Schwerschlag, Paul F. Schendel
  • 5,11-dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents
    Publication number: 20020183310
    Abstract: This invention provides estrogen receptor modulators of formula 1, having the structure 1
    Type: Application
    Filed: April 15, 2002
    Publication date: December 5, 2002
    Applicant: Wyeth
    Inventors: Christopher P. Miller, Michael D. Collini, Heather A. Harris, James C. Keith
  • Methods and compositions for diagnosing and treating preeclampsia and gestational trophoblast disorders
    Publication number: 20020102530
    Abstract: The invention provides methods for identifying compounds which are modulators of syncytin expression. The invention also provides methods for diagnosing a subject who is suffering from or at risk for developing preeclampsia, and kits for diagnosing such a subject. The invention further provides methods for treating a subject who is suffering from or at risk for developing preeclampsia. The invention still further provides methods for treating a subject who is suffering from a gestational trophoblast disorder.
    Type: Application
    Filed: July 9, 2001
    Publication date: August 1, 2002
    Inventors: James C. Keith, John M. McCoy, Sha Mi
  • Use of interleukin-11 to treat gastrointestinal disorders
    Publication number: 20010046482
    Abstract: The use of interleukin-11 to prevent, to ameliorate, and to treat a gastrointestinal disorder in a mammal in need of such treatment is disclosed.
    Type: Application
    Filed: August 1, 2001
    Publication date: November 29, 2001
    Applicant: Genetics Institute
    Inventors: James C. Keith, Theo L. Peeters, Inge Depoortere, G. Van Asche
  • Methods of treating inflammatory bowel diseases by administering IL-11
    Patent number: 6126933
    Abstract: Provided by the present invention are topical formulations of Interleukin-11 and methods for treating a variety of disorders, including inflammatory bowel diseases (e.g., Crohn's disease, ulcerative colitis, indeterminate colitis, and infectious colitis), mucositis (e.g., oral mucositis, gastrointestinal mucositis, nasal mucositis, and proctitis), necrotizing enterocolitis, inflammatory skin disorders (e.g., psoriasis, atopic dermatitis, and contact hypersensitivity), aphthous ulcers, pharyngitis, esophagitis, peptic ulcers, gingivitis, periodontitis, and ocular diseases (e.g., conjunctivitis, retinitis, and uveitis).
    Type: Grant
    Filed: October 26, 1998
    Date of Patent: October 3, 2000
    Assignee: Genetics Institute
    Inventors: Nick W. Warne, Camille L. Bedrosian, James C. Keith, Jr., Ullrich S. Schwertschlag, Paul F. Schendel
  • Methods of treating preeclampsia
    Patent number: 5580554
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of gestational hypertension or preeclampsia. The methods involve measuring serum M-CSF levels, and administration of M-CSF.
    Type: Grant
    Filed: March 23, 1995
    Date of Patent: December 3, 1996
    Assignees: Genetics Institute, Inc., Virginia Polytechnic Institute and State University
    Inventor: James C. Keith
  • Methods of diagnosing and treating preeclampsia
    Patent number: 5543138
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of gestational hypertension or preeclampsia. The methods involve measuring serum M-CSF levels, and administration of M-CSF.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: August 6, 1996
    Assignees: Genetics Institute, Inc., Virginia Polytechnic Institute and State Univ.
    Inventor: James C. Keith