Patents by Inventor James C. Mikkelsen
James C. Mikkelsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9207249Abstract: The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.Type: GrantFiled: July 29, 2013Date of Patent: December 8, 2015Assignee: Caliper Life Sciences, Inc.Inventors: Michael Greenstein, Colin B Kennedy, James C Mikkelsen, Jr.
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Publication number: 20130315781Abstract: The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.Type: ApplicationFiled: July 29, 2013Publication date: November 28, 2013Applicant: CALIPER LIFE SCIENCES, INC.Inventors: Michael Greenstein, Colin B. Kennedy, James C. Mikkelsen, JR.
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Patent number: 8496875Abstract: The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.Type: GrantFiled: May 20, 2005Date of Patent: July 30, 2013Assignee: Caliper Life Sciences, Inc.Inventors: Michael Greenstein, Colin B. Kennedy, James C. Mikkelsen, Jr.
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Patent number: 7334630Abstract: Apparatus and methods according to the present invention utilize micropumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These micropumps are fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These micropumps also can allow for recapture of evolved gases and deposited materials, which may provide for long-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the spatial and temporal characteristics of the device temperature profiles. Novel enclosed microchannel structures are also described.Type: GrantFiled: May 25, 2005Date of Patent: February 26, 2008Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kenneth E. Goodson, Chuan-Hua Chen, David E. Huber, Linan Jiang, Thomas W. Kenny, Jae-Mo Koo, Daniel J. Laser, James C. Mikkelsen, Juan G. Santiago, Evelyn Ning-Yi Wang, Shulin Zeng, Lian Zhang
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Patent number: 7185697Abstract: Apparatus and methods according to the present invention preferably utilize electroosmotic pumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These electroosmotic pumps are preferably fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These electroosmotic pumps also preferably allow for recapture of evolved gases and deposited materials, which may provide for long-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the special and temporal characteristics of the device temperature profiles.Type: GrantFiled: September 2, 2004Date of Patent: March 6, 2007Assignee: Board of Trustees of the Leland Stanford Junior UniversityInventors: Kenneth E. Goodson, Chuan-Hua Chen, David E. Huber, Linan Jiang, Thomas W. Kenny, Jae-Mo Koo, Daniel J. Laser, James C. Mikkelsen, Juan G. Santiago, Evelyn Ning-Yi Wang, Shulin Zeng, Lian Zhang
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Patent number: 7131486Abstract: Apparatus and methods according to the present invention preferably utilize electroosmotic pumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These electroosmotic pumps are preferably fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These electroosmotic pumps also preferably allow for recapture of evolved gases and deposited materials, which may provide for long-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the special and temporal characteristics of the device temperature profiles.Type: GrantFiled: March 10, 2003Date of Patent: November 7, 2006Assignee: The Board of Trustees of the Leland Stanford Junior UniverstyInventors: Kenneth E. Goodson, Chuan-Hua Chen, David E. Huber, Linan Jiang, Thomas W. Kenny, Jae-Mo Koo, Daniel J. Laser, James C. Mikkelsen, Juan G. Santiago, Evelyn Ning-Yi Wang, Shulin Zeng, Lian Zhang
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Patent number: 7070681Abstract: A novel electrokinetic instability (EKI) micromixer and method takes advantage of the EKI to effect active rapid stirring of confluent microstreams of biomolecules without moving parts or complex microfabrication processes. The EKI is induced using an alternating current (A/C) electric field. Within seconds, the randomly fluctuating, three-dimensional velocity field created by the EKI rapidly and effectively stirs an initially heterogeneous solution and generates a homogeneous solution that is useful in a variety of biochemical and bioanalytical systems. Microfabricated on a glass substrate, the inventive EKI micromixer can be easily and advantageously integrated in molecular diagnostics apparatuses and systems, such as a chip-based “Lab-on-a-Chip” microfluidic device.Type: GrantFiled: January 24, 2002Date of Patent: July 4, 2006Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Juan G. Santiago, Michael H. Oddy, James C. Mikkelsen, Jr.
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Patent number: 6991024Abstract: Apparatus and methods according to the present invention preferably utilize electroosmotic pumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These electroosmotic pumps are preferably fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These electroosmotic pumps also preferably allow for recapture of evolved gases and deposited materials, which may provide for long-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the special and temporal characteristics of the device temperature profiles.Type: GrantFiled: June 27, 2003Date of Patent: January 31, 2006Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kenneth E. Goodson, Chuan-Hua Chen, David E. Huber, Linan Jiang, Thomas W. Kenny, Jae-Mo Koo, Daniel J. Laser, James C. Mikkelsen, Juan G. Santiago, Evelyn Ning-Yi Wang, Shulin Zeng, Lian Zhang
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Patent number: 6942018Abstract: Apparatus and methods according to the present invention preferably utilize electroosmotic pumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These electroosmotic pumps are preferably fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These electroosmotic pumps also preferably allow for recapture of evolved gases and deposited materials, which may provide for long-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the special and temporal characteristics of the device temperature profiles.Type: GrantFiled: January 19, 2002Date of Patent: September 13, 2005Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kenneth E. Goodson, Chuan-Hua Chen, David E. Huber, Linan Jiang, Thomas W. Kenny, Jae-Mo Koo, Daniel J. Laser, James C. Mikkelsen, Juan G. Santiago, Evelyn Ning-Yi Wang, Shulin Zeng, Lian Zhang
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Publication number: 20040089442Abstract: Apparatus and methods according to the present invention preferably utilize electroosmotic pumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These electroosmotic pumps are preferably fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These electroosmotic pumps also preferably allow for recapture of evolved gases and deposited materials, which may provide for long-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the special and temporal characteristics of the device temperature profiles.Type: ApplicationFiled: June 27, 2003Publication date: May 13, 2004Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kenneth E. Goodson, Chuan-Hua Chen, David E. Huber, Linan Jiang, Thomas W. Kenny, Jae Mo Koo, Daniel J. Laser, James C. Mikkelsen, Juan G. Santiago, Evely Ning-Yi Wang, Shulin Zeng, Lian Zhang
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Patent number: 6703074Abstract: A display comprised of a first component containing spheres encapsulated within a wax, and thereover and thereunder said component substrates.Type: GrantFiled: March 12, 2002Date of Patent: March 9, 2004Assignee: Xerox CorporationInventors: Guerino G. Sacripante, James C. Mikkelsen, Jr.
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Publication number: 20030164231Abstract: Apparatus and methods according to the present invention preferably utilize electroosmotic pumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These electroosmotic pumps are preferably fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These electroosmotic pumps also preferably allow for recapture of evolved gases and deposited materials, which may provide for long-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the special and temporal characteristics of the device temperature profiles.Type: ApplicationFiled: March 10, 2003Publication date: September 4, 2003Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kenneth E. Goodson, Chuan-Hua Chen, David E. Huber, Linan Jiang, Thomas W. Kenny, Jae Mo Koo, Daniel J. Laser, James C. Mikkelsen, Juan G. Santiago, Evelyn Ning-Yi Wang, Shulin Zeng, Lian Zhang
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Patent number: 6559820Abstract: A display is provided with an insulative layer with electrical properties which have been selected so that the display can be addressed with a stylus and which minimizes the effects of stray triboelectrically generated charges. Also provided is a method of addressing such a display by depositing charges on a surface of the display, maintaining sufficient charge to effect an image change, and then removing the charges.Type: GrantFiled: November 24, 1999Date of Patent: May 6, 2003Assignee: Xerox CorporationInventors: James C. Mikkelsen, Jr., Nicholas K. Sheridon, Edward A. Richley
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Publication number: 20030062149Abstract: Apparatus and methods according to the present invention preferably utilize electroosmotic pumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These electroosmotic pumps are preferably fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These electroosmotic pumps also preferably allow for recapture of evolved gases and deposited materials, which may provide for long-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the special and temporal characteristics of the device temperature profiles.Type: ApplicationFiled: January 19, 2002Publication date: April 3, 2003Inventors: Kenneth E. Goodson, Chuan-Hua Chen, David E. Huber, Linan Jiang, Thomas W. Kenny, Jae-Mo Koo, Daniel J. Laser, James C. Mikkelsen, Juan G. Santiago, Evelyn Ning-Yi Wang, Shulin Zeng, Lian Zhang
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Patent number: 6507333Abstract: A display is provided with an insulative layer with electrical properties which have been selected so that the display can be addressed with a stylus and which minimizes the effects of stray triboelectrically generated charges. Also provided is a method of addressing such a display by depositing charges on a surface of the display, maintaining sufficient charge to effect an image change, and then removing the charges.Type: GrantFiled: November 24, 1999Date of Patent: January 14, 2003Assignee: Xerox CorporationInventors: James C. Mikkelsen, Jr., Nicholas K. Sheridon, Edward A. Richley
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Publication number: 20020125134Abstract: A novel electrokinetic instability (EKI) micromixer and method takes advantage of the EKI to effect active rapid stirring of confluent microstreams of biomolecules without moving parts or complex microfabrication processes. The EKI is induced using an alternating current (A/C) electric field. Within seconds, the randomly fluctuating, three-dimensional velocity field created by the EKI rapidly and effectively stirs an initially heterogeneous solution and generates a homogeneous solution that is useful in a variety of biochemical and bioanalytical systems. Microfabricated on a glass substrate, the inventive EKI micromixer can be easily and advantageously integrated in molecular diagnostics apparatuses and systems, such as a chip-based “Lab-on-a-Chip” microfluidic device.Type: ApplicationFiled: January 24, 2002Publication date: September 12, 2002Inventors: Juan G. Santiago, Michael H. Oddy, James C. Mikkelsen
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Publication number: 20020094377Abstract: A display comprised of a first component containing spheres encapsulated within a wax, and thereover and thereunder said component substrates.Type: ApplicationFiled: March 12, 2002Publication date: July 18, 2002Applicant: Xerox CorporationInventors: Guerino G. Sacripante, James C. Mikkelsen
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Patent number: 6419982Abstract: A display comprised of a first component containing spheres encapsulated within a wax, and thereover and thereunder said component substrates.Type: GrantFiled: March 21, 2001Date of Patent: July 16, 2002Assignee: Xerox CorporationInventors: Guerino G. Sacripante, James C. Mikkelsen, Jr.
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Publication number: 20010051263Abstract: A display comprised of a first component containing spheres encapsulated within a wax, and thereover and thereunder said component substrates.Type: ApplicationFiled: March 21, 2001Publication date: December 13, 2001Applicant: Xerox CorporationInventors: Guerino G. Sacripante, James C. Mikkelsen
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Patent number: 6243058Abstract: A display is provided with an insulative layer whose electrical properties have been selected so that the display can be addressed by the effects of triboelectrically generated charges and thus requires no stylus or special writing utensil. Thus, the display can be addressed by dragging a finger across the display. Alternately, the display is provided with an insulafive layer whoes electrical properties have been selected so that the display is addressed with a stylus and is immune from the effects of stray riboelectrically generated charges.Type: GrantFiled: March 25, 1999Date of Patent: June 5, 2001Assignee: Xerox CoporationInventors: James C. Mikkelsen, Nicholas K. Sheridon, Edward A. Richley