Abstract: A ferrofluidic seal arrangement for sealing a high-speed rotary shaft which passes between an environment at atmospheric or high pressure and an environment at high-vacuum is provided, which is especially useful in a high-speed rotating anode apparatus for generating x-rays in a CAT Scan apparatus or the like. A differentially-pumped region between a multi-stage ferrofluidic seal and a single-stage seal insures that no seal bursting into the high-vacuum region occurs. Bearings supporting the shaft are arranged in a mechanically-stable arrangement but are isolated from the high-vacuum environment. Thus, neither the high-vacuum environment nor the differentially-pumped region need be continually mechanically pumped, and a relatively light-weight apparatus results.