Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

Abstract: An adjustable carriage assembly is configured to be mounted on a frame member of a weight rack and includes a locking structure for locking the carriage assembly in place on the frame member. The carriage assembly may include a moveable carriage with a plurality of rollers that engage the frame member, as well as one or more handles for gripping to adjust the position of the carriage assembly and a connection structure for connection of an implement or accessory. Various implements and accessories can be connected to or used in connection with the carriage assembly, including various weightlifting implements and accessories that are pivotably connected to the carriage assembly.

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

Abstract: Provided herein are formulations and methods of use of 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide or a stereoisomer or mixture of stereoisomers, pharmaceutically acceptable salt, tautomer, prodrug, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

Abstract: A machine for carrying out at least one operation onto a first article and a second article is disclosed. The machine comprises feeding means for advancing a succession of the first article and the second article along a path and with a first speed; a first operative group, which comprises a first tool configured for carrying out operation onto the first article and which can be operated with a second speed associated to the first speed; gap creating means selectively controllable to create a first gap, which is arranged inside succession and is bounded between the first article and the second article; and a second operative group, which comprises a second tool configured for carrying out operation onto the second article and which can be operated at the second speed.

Abstract: A labelling group for applying at least one label onto a respective article at an application station is disclosed. The labelling group comprises a transfer element, which is adapted to transfer the label along a trajectory which comprises a transfer station, and can be arranged in an operative position, in which the transfer station coincides, in use, with the application station; and a diverting device, which can be selectively arranged in: a first configuration, which allows the transfer element to convey the label along at least part of the trajectory and to release the label at the transfer station; or in a second configuration, which prevents the transfer element either from receiving the label or from releasing the label to the transfer station. The transfer element is movable in at least one rest position, in which the trajectory is spaced from the application station.

Abstract: A labelling machine for applying a first label and a second label onto a first article and a second article is disclosed. The labelling machine comprises a first conveyor for conveying a succession of the first article and the second article along a path; a first labelling group, which can be selectively arranged in a first operative configuration; and gap creating means adapted to create a first gap, which is arranged inside the succession and is bounded between the first article and the second article. The first labelling group is selectively arrangeable in a first rest configuration. The labelling machine further comprises a second labelling group, which can be selectively moved between a second rest configuration and a second operative configuration, in which the second labelling group transfers, in use, the second label to the second article.

Abstract: The present disclosure relates to a labeling apparatus for labeling articles. In one implementation, the apparatus may include a transfer drum having at least one label retaining segment adapted to receive and to retain at least one label, a glue application unit adapted to apply glue onto the label, a cleaning unit adapted to clean the transfer drum and a control unit adapted to selectively activate the cleaning unit into at least any one of: a partial cleaning configuration in which the cleaning unit is configured to partially clean the at least one label retaining segment or a full cleaning configuration in which the cleaning unit is configured to fully clean the at least one label retaining segment.

Abstract: There is disclosed a labelling group for advancing a series of labels to be applied onto relative articles. In one implementation, the labelling group may include a first drum adapted to convey a strip of labels along a first path and towards a transfer station; a cutting mechanism adapted to cut a sequence of single labels from the strip; a second drum fed by first drum with cut single labels at the transfer station and adapted to convey simultaneously a required number of cut single labels along a second path. The first drum may move at a first tangential speed at the transfer station, and the second drum may move at a second tangential speed at the transfer station, where the first tangential speed is different from the second tangential speed and is adjusted on the basis of required number of cut labels to be simultaneously conveyed on second drum.

Abstract: The present embodiments providing methods, systems and apparatuses of protecting a surface during laser machining. In some embodiments, a method of protecting a surface during laser machining comprises: directing a fluid into a cavity of an object being laser machined, where the fluid does not have laser absorption properties; and directing a plurality of laser pulses at a wall of the object being laser machined, where the laser pulses are configured to form a hole through the wall such that at least one laser pulse passes through the hole and enters the cavity while the fluid is directed into the cavity such that the laser pulse is incident on the fluid and a surface together in order to inhibit backwall damage.

Abstract: A gluing system for applying glue on products is disclosed. The gluing system includes a glue applicator configured to deposit melted glue on products, a glue container configured to contain excess melted glue discharged from the applicator and fresh melted glue, a glue delivering unit configured to deliver glue from the container to the applicator and a glue discharging unit configured to convey excess glue not used by the applicator to the container. The container is divided by a partition into a first chamber, containing the fresh melted glue, and into a second chamber containing the excess melted glue and separated from the first chamber. The partition includes a filter allowing flow of the fresh melted glue and the excess melted glue from both the first and second chambers to the delivering unit.

Abstract: There is described a labeling apparatus (1) for applying labels (2) onto a succession of articles (3) and a method of setting-up of said labeling apparatus (1) prior to the application of the labels (2). The labeling apparatus (1) comprises a transfer drum (21) for retaining on its outer surface (22) labels (2), a glue application roller (19) having an outer lateral surface (20) and being configured to apply a pattern of glue onto the labels (2). The transfer drum (21) comprises a plurality of pad assemblies (24) arranged along its outer surface (22) and pad assembly alignment means (42) configured to modify orientation and/or position of each one of the plurality of pad assemblies (24) to a respective working configuration for aligning each one of the plurality of pad assemblies (24) with respect to the outer lateral surface (20) of the glue application roller (19).

Abstract: There is disclosed a container processing machine comprising a material handling surface for handling a sheet-like material through suction and a vacuum source in fluid connection with said material handling surface, the machine including means for detecting and transmitting a value of pressure of the gas being suctioned; a controllably operable flow valve; a control unit operatively connected with said detection and transmission means and with said flow valve; said detection and transmission means and said flow valve being arranged between said vacuum source and said material handling surface; said control unit being programmed to adjust the degree of opening of said flow valve in response to a signal which is a function of at least said value of pressure.

Abstract: A method of handling a web-like labelling material in an automated labelling process is disclosed. The method comprises feeding a succession of labels at an input station; and conveying the labels along a circular label path from the input station to an application station located at a first angular distance from the input station as measured about an axis, at the application station means being provided for applying the labels onto respective articles fed, in succession, to the application station. The method further comprises selectively conveying the labels along the circular label path past the application station and to a discarding station located at a second angular distance from the input station as measured about an axis, the second angular distance being greater than the first angular distance.

Abstract: A label application apparatus comprising: an input station, at which a succession of separate labels is formed; an application station, at which each of the labels is applied on a respective article advancing along an article path; a transfer drum configured to retain each label on an outer lateral surface of the transfer drum by suction and to rotate about an axis to transfer each of the labels from the input station to the application station along a label path; a glue applicator arranged peripherally with respect to the transfer drum between the input and application stations with reference to the label path; and a laser emitter arranged peripherally with respect to the transfer drum and configured to generate a laser beam towards the transfer drum to remove at least one of dirt or glue residues from the outer lateral surface of the transfer drum.

Abstract: In general, the subject matter described in this specification can be embodied in methods, systems, and program products for adaptive data unit transmission. A sliding window is filled with data units and designates a sliding window start position and a sliding window end position. A value for each of the data units in the sliding window is stored, the value representing a maximum number of times that each data unit is to be transmitted. The stored value is different among at least two of the data units. Data units are selected from the sliding window to be assembled into a packet. An assembled packet is transmitted to a receiving computerized device. A determination that the data unit positioned at the sliding window start position has been transmitted a maximum number of time is performed, and in response a different data unit is positioned at the sliding window start position.

Abstract: A gluing system for applying glue on products is disclosed. The gluing system includes a glue applicator configured to deposit melted glue on products, a glue container configured to contain excess melted glue discharged from the applicator and fresh melted glue, a glue delivering unit configured to deliver glue from the container to the applicator and a glue discharging unit configured to convey excess glue not used by the applicator to the container. The container is divided by a partition into a first chamber, containing the fresh melted glue, and into a second chamber containing the excess melted glue and separated from the first chamber. The partition includes a filter allowing flow of the fresh melted glue and the excess melted glue from both the first and second chambers to the delivering unit.

Abstract: A stationary blade assembly for cutting labels from a label film in labelling machines, including: a support, a blade supported by said support; blade, a pair of first surfaces interposed between a second surface and a corresponding third surface transversal to the second surface. The stationary blade includes at least two cutting edges which are adapted to cut said labels.