Patents by Inventor James Casey Lippmeier

James Casey Lippmeier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190211369
    Abstract: The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.
    Type: Application
    Filed: January 16, 2019
    Publication date: July 11, 2019
    Inventors: Kirk E. APT, James Casey LIPPMEIER, David SIMPSON, Jun WANG, James P. WYNN, Ross ZIRKLE
  • Publication number: 20190177754
    Abstract: The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.
    Type: Application
    Filed: February 12, 2019
    Publication date: June 13, 2019
    Inventors: James Casey LIPPMEIER, Joseph W. PFEIFER, III, Jon Milton HANSEN, Kirk E. APT, William Robert BARCLAY, Paul Warren BEHRENS, David Christian MARTIN
  • Patent number: 10308965
    Abstract: The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: June 4, 2019
    Assignee: DSM IP Assets B.V.
    Inventors: James Casey Lippmeier, Joseph W. Pfeifer, III, Jon Milton Hansen, III, Kirk E. Apt, William Robert Barclay, Paul Warren Behrens, David Christian Martin
  • Publication number: 20180171310
    Abstract: This disclosure concerns a novel modular docosahexaenoic acid (DHA) synthase and recombinant host organisms genetically modified with such synthase and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The disclosure also concerns methods of making and using such organisms as well as products obtained from such organisms.
    Type: Application
    Filed: June 6, 2016
    Publication date: June 21, 2018
    Inventors: James G. METZ, Jun WANG, Bastien CHEVREUX, Ross E. ZIRKLE, Anne-Cecile BAYNE, James Casey LIPPMEIER
  • Patent number: 9834799
    Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: December 5, 2017
    Assignee: DSM IP Assets B.V.
    Inventors: Paul W Behrens, John M Thompson, Kirk Apt, Joseph W. Pfeifer, III, James P Wynn, James Casey Lippmeier, Jaouad Fichtali, Jon Hansen
  • Publication number: 20170191023
    Abstract: The present invention is directed to recombinant thraustochytrids that grow on xylose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.
    Type: Application
    Filed: January 6, 2017
    Publication date: July 6, 2017
    Inventors: James Casey LIPPMEIER, Kirk E. Apt
  • Publication number: 20170183669
    Abstract: The present invention is directed to recombinant thraustochytrids that grow on sucrose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.
    Type: Application
    Filed: January 6, 2017
    Publication date: June 29, 2017
    Inventors: James Casey LIPPMEIER, Kirk E. Apt, Jon Milton Hansen
  • Publication number: 20170145461
    Abstract: The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.
    Type: Application
    Filed: November 3, 2016
    Publication date: May 25, 2017
    Inventors: Kirk E. APT, James Casey LIPPMEIER, David SIMPSON, Jun WANG, James P. WYNN, Ross ZIRKLE
  • Patent number: 9518102
    Abstract: The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: December 13, 2016
    Assignee: DSM IP Assets B.V.
    Inventors: Kirk E. Apt, James Casey Lippmeier, David Simpson, Jun Wang, James P. Wynn, Ross Zirkle
  • Publication number: 20160355851
    Abstract: The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.
    Type: Application
    Filed: August 16, 2016
    Publication date: December 8, 2016
    Inventors: James Casey LIPPMEIER, Joseph W. PFEIFER, III, Jon Milton HANSEN, III, Kirk E. APT, William Robert BARCLAY, Paul Warren BEHRENS, David Christian MARTIN
  • Patent number: 9453172
    Abstract: The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: September 27, 2016
    Assignee: DSM IP Assets B.V.
    Inventors: James Casey Lippmeier, Joseph W. Pfeifer, III, Jon Milton Hansen, Kirk E. Apt, William Robert Barclay, Paul Warren Behrens, David Christian Martin
  • Patent number: 9382521
    Abstract: Disclosed are novel acyl-CoA synthetases and novel acyltransferases, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified organisms (microorganisms and plants) comprising the same, and methods of making and using the same. Also disclosed are genetically modified organisms (e.g., plants, microorganisms) that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system or PUFA synthase), wherein the organisms have been modified to express an acyl-CoA synthetase, to express an acyl transferase, to delete or inactivate a fatty acid synthase (FAS) expressed by the organism, to reduce competition for malonyl CoA with the PUFA synthase or to increase the level of malonyl CoA in the organism, and in one aspect, to inhibit KASII or KASIII.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: July 5, 2016
    Assignee: DSM IP Assets B.V.
    Inventors: James G. Metz, Jerry M. Kuner, James Casey Lippmeier
  • Publication number: 20160108443
    Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
    Type: Application
    Filed: December 18, 2015
    Publication date: April 21, 2016
    Inventors: Paul W. BEHRENS, John M. THOMPSON, Kirk APT, Joseph W. PFEIFER, James P. WYNN, James Casey LIPPMEIER, Jaouad FICHTALI, Jon HANSEN
  • Patent number: 9249434
    Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: February 2, 2016
    Assignee: DSM IP Assets B.V.
    Inventors: Paul W Behrens, John M Thompson, Kirk Apt, Joseph W Pfeifer, James P Wynn, James Casey Lippmeier, Jaouad Fichtali, Jon Hansen
  • Publication number: 20150132803
    Abstract: The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.
    Type: Application
    Filed: November 19, 2014
    Publication date: May 14, 2015
    Inventors: Kirk E. APT, James Casey LIPPMEIER, David SIMPSON, Jun WANG, James P. WYNN, Ross ZIRKLE
  • Publication number: 20150110826
    Abstract: The present invention relates to recombinant microalgal cells and their use in heterologous protein production, methods of production of heterologous polypeptides in microalgal extracellular bodies, microalgal extracellular bodies comprising heterologous polypeptides, and compositions comprising the same.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Applicant: SANOFI VACCINE TECHNOLOGIES, S.A.S.
    Inventors: Anne-Cecile V. BAYNE, James Casey LIPPMEIER, Kirk Emil APT, Ross Eric ZIRKLE
  • Patent number: 9012616
    Abstract: The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: April 21, 2015
    Assignee: DSM IP Assets B.V.
    Inventors: Kirk E. Apt, James Casey Lippmeier, David Simpson, Jun Wang, James P. Wynn, Ross Zirkle
  • Patent number: 9012197
    Abstract: The present invention is directed to recombinant microalgal cells and their use in production of heterologous hemagglutinin-neuraminidase (HN) polypeptides, as well as compositions and uses thereof.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: April 21, 2015
    Assignees: Merial, Inc., Sanofi Vaccine Technologies, S.A.S.
    Inventors: Anne-C├ęcile V. Bayne, James Casey Lippmeier, Kirk Emil Apt, Xuan Guo, Joyce A. Pritchard
  • Publication number: 20140289904
    Abstract: Disclosed are novel acyl-CoA synthetases and novel acyltransferases, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified organisms (microorganisms and plants) comprising the same, and methods of making and using the same. Also disclosed are genetically modified organisms (e.g., plants, microorganisms) that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system or PUFA synthase), wherein the organisms have been modified to express an acyl-CoA synthetase, to express an acyl transferase, to delete or inactivate a fatty acid synthase (FAS) expressed by the organism, to reduce competition for malonyl CoA with the PUFA synthase or to increase the level of malonyl CoA in the organism, and in one aspect, to inhibit KASII or KASIII.
    Type: Application
    Filed: March 21, 2013
    Publication date: September 25, 2014
    Applicant: DSM IP Assets B.V.
    Inventors: James G. METZ, Jerry M. Kuner, James Casey Lippmeier
  • Publication number: 20140142331
    Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
    Type: Application
    Filed: January 27, 2014
    Publication date: May 22, 2014
    Inventors: Paul W. BEHRENS, John M. THOMPSON, Kirk APT, Joseph W. PFEIFER, James P. WYNN, James Casey LIPPMEIER, Jaouad FICHTALI, Jon HANSEN