Abstract: This invention provides a multistage emulsion polymer including, as copolymerized units: from 0.5% to 5%, by weight P-acid monomer, based on the weight of the emulsion polymer; from 0% to 0.05% by weight multiethylenically unsaturated monomer, based on the weight of the emulsion polymer; and at least one second monoethylenically unsaturated monomer; the emulsion polymer having a calculated Tg of from ?20° C. to 50° C.; the emulsion polymer is formed by the “pulsed” addition of 75% to 100% of the P-acid monomer during a stage including from 10% to 50% of the total monomer weight, preferably added during the relatively early stages of the polymerization. A multistage polymer/TiO2 composite particle and an aqueous coating composition including the composite particle are also provided.

Abstract: The present invention relates to a composition comprising a stable aqueous dispersion of polymer particles, an oxidoreductase, and a cofactor for the oxidoreductase and a method for its preparation. The invention is useful for converting certain classes of VOCs to non-VOCs.

Abstract: An organic polymer including internal pendant phosphorous acid groups at a level of >0.25% phosphorus by weight based on the weight of said organic polymer, the phosphorus acid groups being separated from the backbone of the organic polymer by no more than 2 alkylene glycol units, the organic polymer having an acid number of from 100 to 1,000, and a Mw of from 1,000 to 75,000, wherein the organic polymer has been formed by emulsion polymerization from at least one ethylenically unsaturated monomer is provided. Compositions further including an emulsion polymer including from 0.05% to 2% phosphorous, present as pendant phosphorous acid groups, by weight based on the weight of the emulsion polymer, and, optionally, an inorganic particle are also provided as are processes related to the compositions.

Abstract: The present invention relates to a process for preparing a multistage phosphorus acid functionalized latex polymer comprising the steps of: a) contacting a first acrylic monomer with a first phosphorus acid monomer under emulsion polymerization conditions to form a first stage polymer; then b) contacting the first stage polymer with a second acrylic monomer and a second phosphorus acid monomer under emulsion polymerization conditions to form the latex polymer. The latex polymer is useful as an absorbing polymer for pigment particles used, for example, in coatings formulations.

Abstract: This invention provides a method for forming a stable aqueous composition including composite particles by admixing TiO2 particles and adsorbing emulsion polymer particles at or below the critical composite ratio to an equilibrated viscosity range of from 200 cps to 4000 cps. Also provided is a method for forming a stable aqueous composition including composite particles by admixing TiO2 particles and adsorbing emulsion polymer particles at a mixing intensity of greater than 2 hp/kgal. A method for providing a coating including composite particles is also included.

Abstract: The present invention relates to a composition comprising a stable aqueous dispersion of polymer particles, an oxidoreductase, and a cofactor for the oxidoreductase and a method for its preparation. The invention is useful for converting certain classes of VOCs to non-VOCs.

Abstract: This invention provides a method for forming a stable aqueous composition including composite particles by admixing TiO2 particles and adsorbing emulsion polymer particles at or below the critical composite ratio to an equilibrated viscosity range of from 200 cps to 4000 cps. Also provided is a method for forming a stable aqueous composition including composite particles by admixing TiO2 particles and adsorbing emulsion polymer particles at a mixing intensity of greater than 2 hp/kgal. A method for providing a coating including composite particles is also included.

Abstract: This invention provides a multistage emulsion polymer including, as copolymerized units: from 0.5% to 5%, by weight P-acid monomer, based on the weight of the emulsion polymer; from 0% to 0.05% by weight multiethylenically unsaturated monomer, based on the weight of the emulsion polymer; and at least one second monoethylenically unsaturated monomer; the emulsion polymer having a calculated Tg of from ?20° C. to 50° C.; the emulsion polymer is formed by the “pulsed” addition of 75% to 100% of the P-acid monomer during a stage including from 10% to 50% of the total monomer weight, preferably added during the relatively early stages of the polymerization. A multistage polymer/TiO2 composite particle and an aqueous coating composition including the composite particle are also provided.

Abstract: A macroporous core-shell resin bead having carboxylic acid groups; the bead has from 3% to 100% of monomer residues derived from crosslinker, an average pore diameter of at least 1.5 nm, and an average particle size from 10 ?m to 900 ?m; wherein at least 90% of the carboxylic acid groups in the bead are in the shell region, and the shell region comprises from 5% to 75% of the bead by volume.

Abstract: An organic polymer including internal pendant phosphorous acid groups at a level of >0.25% phosphorus by weight based on the weight of said organic polymer, the phosphorus acid groups being separated from the backbone of the organic polymer by no more than 2 alkylene glycol units, the organic polymer having an acid number of from 100 to 1,000, and a Mw of from 1,000 to 75,000, wherein the organic polymer has been formed by emulsion polymerization from at least one ethylenically unsaturated monomer is provided. Compositions further including an emulsion polymer including from 0.05% to 2% phosphorous, present as pendant phosphorous acid groups, by weight based on the weight of the emulsion polymer, and, optionally, an inorganic particle are also provided as are processes related to the compositions.

Abstract: A method for producing a macroporous acrylic resin in an aqueous suspension from a C1-C4 alkyl acrylate, an organic solvent and a crosslinker.

Abstract: A method for producing a macroporous acrylic resin in an aqueous suspension from a C1-C4 alkyl acrylate, an organic solvent and a crosslinker.

Abstract: A crosslinked polymeric bead comprising a polymer having from 0.5 mole percent to 2 mole percent crosslinker. The bead has a diameter no greater than 200 ?m, no void spaces having a diameter greater than 5 ?m, and less than 5 weight percent of organic extractables.

Abstract: A hydrozirconated matrix for the production of polyolefins is disclosed. The hydrozirconated matrix is prepared from the reaction of an organozirconium composition and an olefin based material. A process is described for using the hydrozirconated matrix to prepare a range of polyolefin products.

Abstract: The present invention provides a method for producing a free flowing and/or non clumping resin that includes prior to drying, shrinking the resin under agitation. In one variant of the invention, the is a resin used in solid phase synthesis of peptides. In another aspect the invention provides a process of making a peptide using the free flowing resin described herein, and a polypeptide made using the process. Various therapeutics are then be made using the polypepdite.

Abstract: A method for functionalizing a crosslinked polymer bead. The method comprises the steps of: (a) swelling the bead in a first solvent or solvent mixture to a volume from 200% to 310% of its volume when dry; and (b) contacting the bead with a functionalizing reagent in a second solvent or solvent mixture capable of swelling the bead to a volume from 200% to 310% of its volume when dry.

Abstract: The present invention relates to an improved process for making commercial quantities of a polypeptide or fragment thereof, e.g. a T-20 or a T-1249 composition, or a fragment of a T-20 or a T-1249 composition. One variant of a T-20 composition is known as Fuzeon™ enfuvirtide. The improvement includes using a low void space resin, a resin made from a copolymer having less than 5% organic extractables, a resin made using a chloride corrosion resistant filter, resin beads functionalized using a nitro-compound, resins made using jetting techniques, and resins made using seed expansion techniques. In yet other variants, the invention provides a composition made using the processes described herein.

Abstract: The present invention relates to a process for making a biologically active substance or therapeutic agent free of a chlorotrityl chloride linker-resin. The process includes reacting an activated amino acid or activated amino acid derivative with a substituted or unsubstituted trityl alcohol resin to obtain a resin-CT-AA product; and, reacting the resin-CT-AA product with other building blocks of the biologically active substance or therapeutic agent to obtain said biologically active substance or therapeutic. A product created by this process is also provided herein. The invention is particularly useful to create T-20 and T-1249 therapeutics.

Abstract: The present invention provides a method and system of making a weak acid cation exchange resin. The method includes converting a swollen form weak acid cation exchange resin to a converted, unswollen form weak acid cation exchange resin, and steam cleaning the converted, unswollen form weak acid cation ion exchange resin to obtain a cleaned weak acid cation exchange resin in an unswollen form. Commercially valuable resins, products containing the resins, products made using the improved resins, and systems containing the resins are also provided herein. Exemplary products and systems include potable water purification systems and disposable cartridges.

Abstract: The present invention provides a method for producing a free flowing and/or non clumping resin that includes prior to drying, shrinking the resin under agitation. In one variant of the invention, the is a resin used in solid phase synthesis of peptides. In another aspect the invention provides a process of making a peptide using the free flowing resin described herein, and a polypeptide made using the process. Various therapeutics are then be made using the polypepdite.