Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: A low-sulfur granulated metallic unit having a mass fraction of sulfur between 0.0001 wt. % and 0.08 wt. % is disclosed herein. Additionally or alternatively, the granulated metallic unit can comprise a mass fraction of phosphorous of at least 0.025 wt. %, a mass fraction of silicon between 0.25 wt. % and 1.5 wt. %, a mass fraction of manganese of at least 0.2 wt. %, a mass fraction of carbon of at least 0.8 wt. %, and/or a mass fraction of iron of at least 94.0 wt. %.

Abstract: A low-carbon granulated metallic unit having a mass fraction of carbon between 0.1 wt. % and 4.0 wt. % is disclosed herein. Additionally or alternatively, the granulated metallic unit can comprise a mass fraction of phosphorous of at least 0.025 wt. %, a mass fraction of silicon between 0.25 wt. % and 1.5 wt. %, a mass fraction of manganese of at least 0.2 wt. %, a mass fraction of sulfur of at least 0.0001 wt. %, and/or a mass fraction of iron of at least 94.0 wt. %.

Abstract: Systems and methods for using a liquid hot metal processing unit to produce granulated metallic units (GMUs) are disclosed herein. In some embodiments of the present technology, a liquid hot metal processing system for producing GMUs comprises a liquid hot metal processing unit including a granulator unit. The granulator unit can include a tilter positioned to receive and tilt a ladle, a controller operably coupled to the tilter to control tilting of the ladle, a tundish positioned to receive the molten metallics from the ladle, and a reactor positioned to receive the molten metallics from the tundish. The reactor can be configured to cool the molten metallics to form granulated metallic units (GMUs).

Abstract: Torpedo cars for use with granulated iron production, and associated systems, devices, and methods are disclosed herein. In some embodiments of the present technology, a torpedo car includes a tilting mechanism, a body rotatably coupled to the tilting mechanism, and a controller operably coupled to the tilting mechanism to control tilting of the body. The body can include (i) an inner surface defining a cavity and a channel, and (ii) an outer surface defining an opening to the cavity and a channel outlet of the channel spaced apart from the opening. The channel can extend between the channel outlet and a channel inlet interfacing the cavity. The inner surface can include a slag dam configured to prevent slag from exiting the opening while the torpedo car tilts. The controller can control the tilting mechanism to control molten metal flow out of the cavity through the channel.

Abstract: Reduced-waste systems and methods for granulated metallic units (GMUs) production are disclosed herein. A representative method can include receiving a first supply of molten iron and producing GMUs by granulating the molten iron poured onto a target material of a reactor. The method can include removing residual fines of the GMUs via a classifier based on a threshold particle size and mixing the residual fines with a second supply of molten iron to produce additional GMUs.

Abstract: Processing granulated metallic units within electric arc furnaces (EAFs) and associated systems, devices, and methods are disclosed herein. A representative method can include receiving granulated metallic units in an EAF, wherein the granulated metallic units comprise no more than 0.05 wt. % of sulfur and at least 50% of particles in the granulated iron material have a particle size of at least 6 millimeters. The method can include applying electrical energy to the granulated iron via electrodes and melting the granulated iron material to form a molten steel product. The method can also include tapping the EAF to remove the molten steel product from the EAF.

Abstract: Systems for continuous granulated metallic unit (GMU) production, and associated devices and methods are disclosed herein. In some embodiments, a continuous GMU production system includes a furnace unit, a desulfurization unit, a plurality of granulator units, and a cooling system. The furnace unit can receive input materials such as iron ore and output molten metal. The desulfurization unit can reduce a sulfur content of the molten metallics received from the furnace unit. Each of the plurality of granulator units can include a tundish that can control the flow of molten metallics and a reactor that can granulate the molten metallics to form GMUs. The cooling system can provide cooled water to the reactor. Continuous GMU production systems configured in accordance with embodiments of the present technology can produce GMUs under continuous operations cycles for, e.g., at least 6 hours.

Abstract: Loading granulated metallic units (GMUs) into railcars, and associated systems, devices, and methods, are disclosed here. In some embodiments, an apparatus for loading GMUs into a railcar comprises a housing unit, a weigh bin, a weigh bin gate, a hopper, and an articulating chute. GMUs in the weigh bin are discharged via gravity through the weigh bin gate when the weigh bin gate opens. The hopper is configured to guide GMUs received from the weigh bin to the articulating chute. The articulating chute is angled and rotatable about an axis of the hopper such that, when rotated, the end of the chute is closer to the floor of a railcar. In some embodiments, the chute includes telescoping segments.

Abstract: Railcars for transporting granulated metallic units, and associated systems, devices, and methods are disclosed herein. For example, a reinforced railcar apparatus includes a container envelope and a reinforcement liner. The container envelope includes side walls and end walls extending from a floor of the railcar. The side walls are a first length and the end walls are a second length less than the first length. Top portions of the rigid side walls and end walls define an opening of the container envelope through which granulated metallic units are discharged into the railcar assembly. The railcar assembly includes angled interior walls coupled to the bottom surface and extending from a top portion of the end walls to the bottom surface. The reinforcement liner is disposed over a portion of the bottom surface and the angled interior walls. In some embodiments, the railcar assembly includes an open-topped box layered with impact-absorbing material.

Abstract: Treating cooling water in industrial production facilities and associated systems, devices, and methods are disclosed herein. The system can comprise a cooling tower with a first and second cell, each having a housing to receive return water and a sump below to maintain supply water configured to directly contact molten metal. The system includes an inlet and an inlet line to provide return water to the cooling tower and an outlet and an outlet line to direct supply water back to the industrial production facility. The inlet, outlet, and cooling tower form a closed-loop network. Additionally, a blowdown line is fluidically coupled to the outlet to divert a portion of the supply water away from the closed-loop network.

Abstract: The present invention provides methods for isolating and cryopreserving tumor infiltrating lymphocytes (TILs) and producing therapeutic populations of TILs, including methods via use of a kit and a semi-automatic device for aseptic disaggregation, enrichment, and cryopreservation of a resected tumor prior to expansion of the TIL population. The present invention also provides methods for expansion, and/or stabilization of TILs, for instance UTILs, compositions involving the same and methods of treatment involving the same.

Abstract: Microfluidic chips and cartridges and systems that include such chips are disclosed. In some embodiments, the chips include a microfluidic channel disposed in a substrate with the channel comprising at least one expansion region. The channel is configured to generate a vortex within the at least one expansion region in response to fluid through the microfluidic channel to trap cells or particles. The substrate in which the channel is formed may be relatively rigid to resist deformation.

Abstract: Disclosed is a context-aware real-time spatial intelligence provision system that estimates the locations of persons or things captured in a video by extracting objects representative of the persons and the things from the video captured by viewing a real space and placing the extracted objects in a virtual space to which a digital twin technique is applied. The disclosed context-aware real-time spatial intelligence provision system allows people to keep the distance between each other indoors, thereby preventing the spread of an infectious disease such as COVID-19.

Abstract: Disclosed is a context-aware real-time spatial intelligence provision system that estimates the locations of persons or things captured in a video by extracting objects representative of the persons and the things from the video captured by viewing a real space and placing the extracted objects in a virtual space to which a digital twin technique is applied. The disclosed context-aware real-time spatial intelligence provision system allows people to keep the distance between each other indoors, thereby preventing the spread of an infectious disease such as COVID-19.

Abstract: Disclosed are an open-porous metal foam and a method for manufacturing the same. An open-porous metal foam according to an exemplary embodiment of the present invention is made of an iron-based alloy including 15 wt % or more of chrome and 5 wt % or more of aluminum. The open-porous metal foam is a semi-product that is formed of iron or the iron-based alloy that does not include chrome and aluminum or includes a smaller amount of chrome and aluminum in the powder when manufacturing, and the surface and the open pore thereof are uniformly coated with the powder of the iron-chrome-aluminum alloy and the organic binding agent. When heat treatment is performed under a reduction atmosphere, sintering is performed.

Abstract: Disclosed are an open-porous metal foam and a method for manufacturing the same. An open-porous metal foam according to an exemplary embodiment of the present invention is made of an iron-based alloy including 15 wt % or more of chrome and 5 wt % or more of aluminum. The open-porous metal foam is a semi-product that is formed of iron or the iron-based alloy that does not include chrome and aluminum or includes a smaller amount of chrome and aluminum in the powder when manufacturing, and the surface and the open pore thereof are uniformly coated with the powder of the iron-chrome-aluminum alloy and the organic binding agent. When heat treatment is performed under a reduction atmosphere, sintering is performed.

Abstract: Disclosed are an open-porous metal foam and a method for manufacturing the same. An open-porous metal foam according to an exemplary embodiment of the present invention is made of an iron-based alloy including 15 wt % or more of chrome and 5 wt % or more of aluminum. The open-porous metal foam is a semi-product that is formed of iron or the iron-based alloy that does not include chrome and aluminum or includes a smaller amount of chrome and aluminum in the powder when manufacturing, and the surface and the open pore thereof are uniformly coated with the powder of the iron-chrome-aluminum alloy and the organic binding agent. When heat treatment is performed under a reduction atmosphere, sintering is performed.