Abstract: Contrast agents are characterized with ultrasound. Flowing or unbound contrast agents are distinguished automatically from bound or relatively stationary contrast agents. The bound or relatively stationary contrast agents are highlighted on a display. A processor distinguishes different types of contrast agents or contrast agents in different binding states with relative signal strength or velocity. Attached contrast agents are differentiated from phagocytosed contrast agents. Monitoring absolute signal strength as a function of time may indicate binding. Any one or more of these features may be used.

Abstract: Contrast agents are manipulated with acoustic radiation force while ultrasound imaging. Continuous waves for acoustic radiation force are transmitted. Substantially simultaneously, pulsed waves for imaging are transmitted. Low mechanical index continuous and pulsed waves may be used to increase binding efficiency of drug containing contrast agents with the tissue for treatment. Various techniques may be used to minimize the effect of the continuous waves on imaging with the pulsed waves. The acoustic radiation force may be transmitted with an amplitude profile and/or unfocused or defocused.

Abstract: Automated determination and setting of an ultrasound system transmit power level is provided for contrast agent imaging. Low mechanical index imaging of contrast agents allows substantially continuous imaging of contrast agents without destruction. By comparing data associated with different transmit power levels and spatial locations, different delays between acquisition or different acquisition sequences, a contrast agent imaging transmit power generally minimizing destruction of contrast agents and maximizing signal-to-noise ratio is automatically determined. By using contrast agent specificity for setting the transmit power in addition or alternative to destruction of contrast agents, harmonic imaging may be improved.

Abstract: Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence.

Abstract: Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence.

Abstract: A target mechanical index, acoustic pressure, intensity or other value associated with contrast agent imaging is established. For contrast agent imaging associated with limited destruction of contrast agents, the transmit power is matched to the target intensity value as a function of position, time or combinations thereof. Given multiple foci, the transmit power is adjusted to provide a substantially uniform acoustic pressure or intensity at two or more of the foci. Where an imaging parameter is adjusted during an imaging session, the transmit power is altered to provide a similar or same target intensity value at a given location that is consistent with the value before the adjustment. By setting the transmit power as a function of a target value, more consistent contrast agent imaging may be provided despite the use of multiple foci, changes in the location of one or more foci, or changes in other imaging parameters.

Abstract: Methods are provided for automatic setting of parameters for contrast agent quantification. Various processes may improve quantification. For example, for consistency in contrast agent quantification, a gain or other setting of an ultrasound system is automatically determined in response to destruction of the contrast agent or at the initiation of the contrast agent quantification procedure. Automatic setting of an adaptive gain provides equalized image intensity for each repetition of a contrast agent quantification procedure based on a same triggering event, the destruction of contrast agent. By synchronizing the adaptive setting algorithms with contrast agent destruction, similar base line information is provided for each iteration of a contrast agent quantification procedure. As another example, the contrast agent gain setting treats acoustic signals representing tissue or other non-contrast agent structure as noise, mapping the tissue values to a substantially constant low value within the dynamic range.

Abstract: A medical imaging system automatically acquires two-dimensional images representing a user-defined region of interest despite motion. The plane of acquisition is updated or altered adaptively as a function of detected motion. The user-designated region of interest is then continually scanned due to the alteration in scan plane position. A multi-dimensional array is used to stabilize imaging of a region of interest in a three-dimensional volume. The user defines a region of interest for two-dimensional imaging. Motion is then detected. The position of a scan plane used to generate a subsequent two-dimensional image is then oriented as a function of the detected motion within the three-dimensional volume. By repeating the motion determination and adaptive alteration of the scan plane position, real time imaging of a same region of interest is provided while minimizing the region of interest fading into or out of the sequence of images.