Abstract: The invention provides methods of treating Friedreich's ataxia using histone deacetylase inhibitors.

Abstract: The present invention generally relates to influenza and, in particular, to systems and methods for studying influenza viruses such as the influenza A virus. One aspect of the invention is generally directed towards systems and methods for determining the timescale dynamics of the tryptophan residue located in position 41 of the M2 proton channel of the influenza A virus, for instance, via nuclear magnetic resonance. This may be useful, for example, in determining whether a candidate drug is able to alter the dynamics of the tryptophan residue, and thus, whether the drug targets the M2 proton channel.

Abstract: A communication provider which provides wireless access to a packetized data network, such as the Internet. The provider includes a server computer. The server computer is connected to the network, which is at least in part a wired network. A client device is also connected to the network, including by wireless means. The wired network is connected to a cellular wireless communications system. Payloads of information communicated by the server computer to the client device are assigned corresponding Global Sequence Numbers. By determining a time differential between next succeeding payloads received by the client, a determination is made whether any payload loss occurs on a wired portion of the network or on a wireless portion of the network. Headers of all payloads of information are compressed together and transmitted together, in order to limit communications and amount of data communicated. A send rate of the server computer is adjusted in relation to an effective receive rate of the client device.

Abstract: An electrical socket has a movable socket holder, a casing and a socket body. The movable socket holder has a pair of jacks, with a curved contact pin is mounted in each jack. The casing has a pair of conductive pieces therein and an opening. The movable socket holder is movably mounted through the opening of the casing outside the casing. The socket body is mounted between the movable socket holder and the casing to either separate the contact pins from the conductive pieces to obtain an electrical disconnection, or contact with the contact pins and the conductive pieces to establish an electrical connection. The interior wiring of the electrical appliance can be safely controlled.

Abstract: An overload prevention plug structure has a power line, a plug and an overload shift. The power line has a hot wire and a ground wire. The plug has a hot wire pin and a ground wire pin. The ground wire pin is electrically connected to the ground wire of the power line. The overload shift has a hot wire contacting portion and a pin contacting portion. The hot wire contacting portion is electrically connected to the hot wire of the power line and the pin contacting portion is electrically connected to the hot wire pin of the plug to establish an electric connection. The overload has a dual metal piece that deforms and bends as its temperature increases. Alternatively, the overload is a positive temperature coefficient (PTC) thermstor with a resistance that increases or decreases as its temperature increases or decreases.

Abstract: A communications service provider provides wireless access to a packetized data network, such as the Internet. The service provider includes a server computer. The server computer is connected to the network, which is at least in part a wired network. The wired network is connected to a cellular wireless communications system. Features of the network and the server computer include group messaging, co-processors, dynamic protocol dictionaries, and cache synchronization and optimization. The features speed and improve communications over the network, including over wireless channels and dynamic conditions of those channels.

Abstract: A communication provider which provides wireless access to a packetized data network, such as the Internet. The provider includes a server computer. The server computer is connected to the network, which is at least in part a wired network. A client device is also connected to the network, including by wireless means. The wired network is connected to a cellular wireless communications system. Payloads of information communicated by the server computer to the client device are assigned corresponding Global Sequence Numbers. By determining a time differential between next succeeding payloads received by the client, a determination is made whether any payload loss occurs on a wired portion of the network or on a wireless portion of the network. Headers of all payloads of information are compressed together and transmitted together, in order to limit communications and amount of data communicated. A send rate of the server computer is adjusted in relation to an effective receive rate of the client device.