Patents by Inventor James Christopher McWilliams

James Christopher McWilliams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for synthesizing a substituted pyrazole
    Patent number: 7709658
    Abstract: The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: May 4, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Lushi Tan, James Christopher McWilliams, Frederick W. Hartner, Naoki Yoshikawa, Wenji Li
  • Process for synthesizing a substituted pyrazole
    Publication number: 20090054662
    Abstract: The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
    Type: Application
    Filed: July 21, 2006
    Publication date: February 26, 2009
    Inventors: Lushi Tan, James Christopher McWilliams, Frederick W. Hartner, Naoki Yoshikawa, Wenji Li
  • Enantioselective bioreduction for the preparation of integrin receptor antagonist intermediates
    Patent number: 6764842
    Abstract: The present invention relates to a novel enantioselective bioreduction using a yeast microorganism for the preparation of the chiral allylic alcohols of structural formula I (R is hydrogen or methyl) which are useful in the asymmetric synthesis of integrin &agr;v&bgr;3 receptor antagonists.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: July 20, 2004
    Assignee: Merck & Co., Inc.
    Inventors: Michael G. Sturr, Russell Fieldon Boyd, Kodzo Gbewonyo, Joseph Nti-Gyabaah, David J. Pollard, James Christopher McWilliams, Kathleen A. Telari
  • Process for preparation of integrin receptor antagonist intermediates
    Publication number: 20040030134
    Abstract: A novel process is provided for the preparation of chiral intermediates useful in the asymmetric syntheses of &agr;v&bgr;3 integrin receptor antagonists. Also provided are the enantiomerically enriched intermediates that are obtained from the process.
    Type: Application
    Filed: September 11, 2003
    Publication date: February 12, 2004
    Inventors: James Christopher McWilliams, Elizabeth Buck, Kan K. Eng, Guy R. Humphrey, Peter E. Maligres, Jess W. Sager, Marjorie See Waters
  • Enantioselective bioreduction for the preparation of integrin receptor antagonist intermediates
    Publication number: 20020187988
    Abstract: The present invention relates to a novel enantioselective bioreduction using a yeast microorganism for the preparation of the chiral allylic alcohols of structural formula I (R is hydrogen or methyl) which are useful in the asymmetric synthesis of integrin &agr;v&bgr;3 receptor antagonists.
    Type: Application
    Filed: March 27, 2002
    Publication date: December 12, 2002
    Inventors: Michael G. Sturr, Russell Fieldon Boyd, Kodzo Gbewonyo, Joseph Nti-Gyabaah, David J. Pollard, James Christopher McWilliams, Kathleen A. Telari