Abstract: The claimed invention addresses the benefits of exogenous ketone supplementation in a subject in need thereof. In particular, the exogenous ketone supplementation includes the natural D-Beta HydroxyButyric acid, also described as natural D-BHB. As detailed in representative FIG. 1, natural D-BHB is preferentially consumed in the brain to glucose and additionally has a wide range of positive regulatory effects on the body and mind. Consumer applications for supplementation with natural D-BHB include improved sleep, anti-hunger, anti-anxiety, improved cognitive enhancement and athletic duration and post workout recovery through consumption of 10 grams or more of natural D-BHB. Therapeutic applications for exogenous natural D-BHB supplementation include anti-cancer, anti-kidney disease, anti-cognitive disorders and improved viral resistance through consumption of 10-20 grams or more of D-Beta HydroxyButyric acid.