Patents by Inventor James Clayton Peacock, III
James Clayton Peacock, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240324892Abstract: An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.Type: ApplicationFiled: November 3, 2023Publication date: October 3, 2024Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane
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Patent number: 12097020Abstract: Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit.Type: GrantFiled: March 27, 2023Date of Patent: September 24, 2024Assignee: ACLARION, INC.Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Ricardo Dario Pradenas
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Patent number: 12016816Abstract: A manual ear pump including one or more of a support element configured to releasably engage an external ear canal and having an interior chamber, a resilient element capable of being resiliently deformed coupled to a support element, and an aperture disposed on a support element bottom surface communicating with the external ear canal and interior chamber.Type: GrantFiled: February 11, 2022Date of Patent: June 25, 2024Assignee: NOCIRA, LLCInventors: David Mager George, James Clayton Peacock, III
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Publication number: 20230414126Abstract: Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit.Type: ApplicationFiled: March 27, 2023Publication date: December 28, 2023Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Ricardo Dario Pradenas
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Patent number: 11844601Abstract: An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.Type: GrantFiled: November 16, 2021Date of Patent: December 19, 2023Assignee: Aclarion, Inc.Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane
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Publication number: 20230355167Abstract: An MR Spectroscopy (MRS) system and approach is provided for measuring spectral information corresponding with propionic acid (PA), either alone or in combination with other measurements corresponding with other chemicals, to diagnose and/or monitor at least one of bacterial infection, such as associated with P. acnes, or conditions related thereto such as nociceptive pain associated with tissue acidity. An interfacing DDD-MRS signal processor receives output signals to produce a post-processed spectrum, with spectral regions corresponding with certain chemicals, including PA, then measured as biomarkers. A diagnostic processor derives a diagnostic value for each disc, and performs certain normalizations, based upon ratios of the spectral regions related to chemicals implicated in degenerative painful tissue pathology, such as PA and hypoxia markers of lactic acid (LA) and alanine (AL), and structural chemicals of proteoglycan (PG) and collagen or carbohydrate (CA).Type: ApplicationFiled: January 27, 2023Publication date: November 9, 2023Inventors: Jeffrey C. Lotz, James Clayton Peacock, III, David S. Bradford, Stefan Dudli, Sergey G. Magnitsky
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Publication number: 20230140742Abstract: Systems and methods are provided for using machine learning (ML) models to evaluate data generated during MRI procedures, such as magnetic resonance spectroscopy (MRS) data, to evaluate patient disc pain. An ML-based disc assessment system can evaluate MRS spectrum data ML models trained to classify the MRS spectrum based on diagnostic and/or outcome-based ground truth data.Type: ApplicationFiled: October 28, 2022Publication date: May 4, 2023Inventors: James Charles Abel, James Clayton Peacock, III, Ricardo Dario Pradenas
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Patent number: 11633124Abstract: Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit.Type: GrantFiled: November 18, 2021Date of Patent: April 25, 2023Assignee: ACLARION, INC.Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Ricardo Dario Pradenas
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Patent number: 11564619Abstract: An MR Spectroscopy (MRS) system and approach is provided for measuring spectral information corresponding with propionic acid (PA), either alone or in combination with other measurements corresponding with other chemicals, to diagnose and/or monitor at least one of bacterial infection, such as associated with P. acnes, or conditions related thereto such as nociceptive pain associated with tissue acidity. An interfacing DDD-MRS signal processor receives output signals to produce a post-processed spectrum, with spectral regions corresponding with certain chemicals, including PA, then measured as biomarkers. A diagnostic processor derives a diagnostic value for each disc, and performs certain normalizations, based upon ratios of the spectral regions related to chemicals implicated in degenerative painful tissue pathology, such as PA and hypoxia markers of lactic acid (LA) and alanine (AL), and structural chemicals of proteoglycan (PG) and collagen or carbohydrate (CA).Type: GrantFiled: December 18, 2018Date of Patent: January 31, 2023Assignees: ACLARION, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Jeffrey C. Lotz, James Clayton Peacock, III, David S. Bradford, Stefan Dudli, Sergey G. Magnitsky
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Publication number: 20220370286Abstract: A manual ear pump including one or more of a support element configured to releasably engage an external ear canal and having an interior chamber, a resilient element capable of being resiliently deformed coupled to a support element, and an aperture disposed on a support element bottom surface communicating with the external ear canal and interior chamber.Type: ApplicationFiled: February 11, 2022Publication date: November 24, 2022Inventors: David Mager George, James Clayton Peacock, III
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Publication number: 20220322957Abstract: Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit.Type: ApplicationFiled: November 18, 2021Publication date: October 13, 2022Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Ricardo Dario Pradenas
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Publication number: 20220175264Abstract: An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.Type: ApplicationFiled: November 16, 2021Publication date: June 9, 2022Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane
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Patent number: 11246793Abstract: A manual ear pump including one or more of a support element configured to releasably engage an external ear canal and having an interior chamber, a resilient element capable of being resiliently deformed coupled to a support element, and an aperture disposed on a support element bottom surface communicating with the external ear canal and interior chamber.Type: GrantFiled: August 23, 2019Date of Patent: February 15, 2022Assignee: NOCIRA, LLCInventors: David Mager George, James Clayton Peacock, III
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Patent number: 11179057Abstract: Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit.Type: GrantFiled: May 7, 2020Date of Patent: November 23, 2021Assignee: NociMed, Inc.Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Ricardo Dario Pradenas
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Publication number: 20210052185Abstract: Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit.Type: ApplicationFiled: May 7, 2020Publication date: February 25, 2021Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Ricardo Dario Pradenas
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Publication number: 20200222272Abstract: A manual ear pump including one or more of a support element configured to releasably engage an external ear canal and having an interior chamber, a resilient element capable of being resiliently deformed coupled to a support element, and an aperture disposed on a support element bottom surface communicating with the external ear canal and interior chamber.Type: ApplicationFiled: August 23, 2019Publication date: July 16, 2020Inventors: David Mager George, James Clayton Peacock, III
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Patent number: 10646135Abstract: Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit.Type: GrantFiled: August 10, 2018Date of Patent: May 12, 2020Assignee: NOCIMED, INC.Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Ricardo Dario Pradenas
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Publication number: 20200100698Abstract: An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.Type: ApplicationFiled: May 9, 2019Publication date: April 2, 2020Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Jeffrey C. Lotz
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Publication number: 20190307393Abstract: An MR Spectroscopy (MRS) system and approach is provided for measuring spectral information corresponding with propionic acid (PA), either alone or in combination with other measurements corresponding with other chemicals, to diagnose and/or monitor at least one of bacterial infection, such as associated with P. acnes, or conditions related thereto such as nociceptive pain associated with tissue acidity. An interfacing DDD-MRS signal processor receives output signals to produce a post-processed spectrum, with spectral regions corresponding with certain chemicals, including PA, then measured as biomarkers. A diagnostic processor derives a diagnostic value for each disc, and performs certain normalizations, based upon ratios of the spectral regions related to chemicals implicated in degenerative painful tissue pathology, such as PA and hypoxia markers of lactic acid (LA) and alanine (AL), and structural chemicals of proteoglycan (PG) and collagen or carbohydrate (CA).Type: ApplicationFiled: December 18, 2018Publication date: October 10, 2019Inventors: Jeffrey C. Lotz, James Clayton Peacock, III, David S. Bradford, Stefan Dudli, Sergey G. Magnitsky
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Publication number: 20190175051Abstract: Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit.Type: ApplicationFiled: August 10, 2018Publication date: June 13, 2019Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Ricardo Dario Pradenas