Abstract: Systems and methods for generating and/or applying an adjustment for one or more parameters of a neuromodulation therapy of a user are provided. One or more physiological-based inputs of the user may be received and a therapy response score may be determined based on the one or more physiological-based inputs. At least one adjustment for one or more parameters of the neuromodulation therapy may be generated based on the therapy response score.

Abstract: A system is provided for informing a therapeutic procedure. In some embodiments, the system may be configured to determine specific states associated with a sleep-wake cycle of a patient. Additionally, the system may be configured to measure one or more signals with cardiac activity of the patient upon detecting the specific states of the sleep-wake cycle of the patient. Subsequently, the system may be configured to determine one or more parameters for applying an electrical signal to an anatomical element of the patient based on the one or more signals with cardiac activity. In some embodiments, the system may be configured to establish a longitudinal trend of cardiac metrics for the patient based on a plurality of signals with cardiac activity for the patient measured during the specific states of the sleep-wake cycle across a plurality of days.

Abstract: A system is provided for identifying and reducing noise in a therapeutic procedure. For example, the system may be configured to measure one or more signals with cardiac activity. The system may be configured to then identify one or more sources of noise that are distorting the one or more signals with cardiac activity and may reduce the one or more sources of noise from the one or more signals with cardiac activity. Subsequently, the system may be configured to determine one or more aggregate cardiac-derived metrics and/or save processed cardiac data based on the one or more signals with cardiac activity with the one or more sources of noise reduced. Additionally, the system may be configured to determine one or more parameters for applying an electrical signal to an anatomical element of a patient based on the one or more aggregate cardiac-derived metrics and/or saved processed cardiac data.

Abstract: Apparatus, systems, and methods for cooling fluids, for example beverages or beverage components, are presented. A cooling system or device includes a cold plate of bulk material (e.g., material of high thermal conductivity). A first sensor (preferably temperature sensor) is positioned within the bulk material and communicatively coupled to a processor. A first fluid line is at least partially disposed within the cold plate, having a first inlet entering and a first outlet exiting the cold plate. A second sensor (preferably temperature sensor) is positioned at the first fluid line proximal to the first outlet and communicatively coupled to the processor. The processor compares a sensor reading from the first sensor with a sensor reading from the second sensor, and issues an error report when the difference between the readings is above a threshold, or an individual reading from a sensor is outside of an operational parameter.

Abstract: A viscous fluid is dispensed precisely using a fluid pump, control valves configured to control both the air inlet and outlet of the fluid pump, an optional adjustable regulator further controlling the air outlet, and a control circuit that opens and closes the control valves. To further increase the precision, additional control valves can be used to control liquid inlet and outlet of the fluid pump.

Abstract: A mutant subtilase cytotoxin B subunit protein is provided which can bind glycans having ?2-3-linked N-glycolylneuraminic acid and glycans having ?2-6-linked N-glycolylneuraminic acid. The mutant SubB protein has deletions of one or more of the amino acid sequence TTSTE and has a previously undescribed ability to bind glycans having ?2-6-linked N-glycolylneuraminic acid, while not losing the ability to bind glycans having ?2-3-linked N-glycolylneuraminic acid.

Abstract: A shutoff switch for dispensing mixed beverages is presented. The shutoff switch includes a syrup inlet receiving syrup and a syrup outlet dispensing the syrup to a pump. The shutoff switch also includes a water inlet receiving water, and a water outlet dispensing the water to a either the pump or a dispensing point. Two distinct inlets and outlets for syrup and water prevent the syrup and water being mixed in the shutoff switch. The shutoff switch further includes a pressure responsive member that deforms based on pressure changes in the shutoff switch. When the deformation of the pressure responsive member reaches a threshold, an electrical gate in direct communication with the pressure responsive member opens, turning of a pump of the beverage dispensing system. Valves in either chamber of the shutoff switch can also be used as a redundant mechanical way to stop flow in the system.

Abstract: A mutant subtilase cytotoxin B subunit protein is provided which can bind glycans having ?2-3-linked N-glycolylneuraminic acid and glycans having ?2-6-linked N-glycolylneuraminic acid. The mutant SubB protein has deletions of one or more of the amino acid sequence TTSTE and has a previously undescribed ability to bind glycans having ?2-6-linked N-glycolylneuraminic acid, while not losing the ability to bind glycans having ?2-3-linked N-glycolylneuraminic acid.

Abstract: The present invention relates to photon-irradiated streptococcal vaccine preparations and methods for their use.

Abstract: The present invention relates to streptococcal vaccine formulations and their use in generating immunity against streptococcal infection.

Abstract: The present invention relates to streptococcal vaccine formulations and their use in generating immunity against streptococcal infection.

Abstract: Apparatus, systems, and methods for cooling fluids, for example beverages or beverage components, are presented. A cooling system or device includes a cold plate of bulk material (e.g., material of high thermal conductivity). A first sensor (preferably temperature sensor) is positioned within the bulk material and communicatively coupled to a processor. A first fluid line is at least partially disposed within the cold plate, having a first inlet entering and a first outlet exiting the cold plate. A second sensor (preferably temperature sensor) is positioned at the first fluid line proximal to the first outlet and communicatively coupled to the processor. The processor compares a sensor reading from the first sensor with a sensor reading from the second sensor, and issues an error report when the difference between the readings is above a threshold, or an individual reading from a sensor is outside of an operational parameter.

Abstract: The present invention relates to photon-irradiated streptococcal vaccine preparations and methods for their use.

Abstract: A shutoff switch for dispensing mixed beverages is presented. The shutoff switch includes a syrup inlet receiving syrup and a syrup outlet dispensing the syrup to a pump. The shutoff switch also includes a water inlet receiving water, and a water outlet dispensing the water to a either the pump or a dispensing point. Two distinct inlets and outlets for syrup and water prevent the syrup and water being mixed in the shutoff switch. The shutoff switch further includes a pressure responsive member that deforms based on pressure changes in the shutoff switch. When the deformation of the pressure responsive member reaches a threshold, an electrical gate in direct communication with the pressure responsive member opens, turning of a pump of the beverage dispensing system. Valves in either chamber of the shutoff switch can also be used as a redundant mechanical way to stop flow in the system.

Abstract: A shutoff switch for dispensing mixed beverages is presented. The shutoff switch includes a syrup inlet receiving syrup and a syrup outlet dispensing the syrup to a pump. The shutoff switch also includes a water inlet receiving water, and a water outlet dispensing the water to a either the pump or a dispensing point. Two distinct inlets and outlets for syrup and water prevent the syrup and water being mixed in the shutoff switch. The shutoff switch further includes a pressure responsive member that deforms based on pressure changes in the shutoff switch. When the deformation of the pressure responsive member reaches a threshold, an electrical gate in direct communication with the pressure responsive member opens, turning of a pump of the beverage dispensing system. Valves in either chamber of the shutoff switch can also be used as a redundant mechanical way to stop flow in the system.

Abstract: The present invention relates to photon-irradiated streptococcal vaccine preparations and methods for their use.

Abstract: Systems, methods, and devices to improve pouring large or unwieldy containers are disclosed. A band couples about or proximal to a rim of a container. In some embodiments, bands are sized and dimensioned to rigidly fit containers with specific shapes and dimensions, though universal or nearly universal bands that flexibly conform to the shape of any container are further contemplated. The band secures a spout portion to a pouring edge of the container. The spout portion includes a shelf extending from the pouring edge and bounded by two side walls having splash guards. The side walls and splash guards serve to funnel food stuffs or liquids towards a receptacle when the container is tipped toward the pouring edge. The spout region further includes an overflow shelf to prevent food stuffs or liquids from spilling out of the container by accident or during rapid pouring. A handle can be further attached to the band to aid a user in lifting and pouring the container.

Abstract: A viscous fluid is dispensed precisely using a fluid pump, control valves configured to control both the air inlet and outlet of the fluid pump, an optional adjustable regulator further controlling the air outlet, and a control circuit that opens and closes the control valves. To further increase the precision, additional control valves can be used to control liquid inlet and outlet of the fluid pump.

Abstract: A mutant subtilase cytotoxin B subunit protein is provided which can bind glycans having ?2-3-linked N-glycolylneuraminic acid and glycans having ?2-6-linked N-glycolylneuraminic acid. The mutant SubB protein has deletions of one or more of the amino acid sequence TTSTE and has a previously undescribed ability to bind glycans having ?2-6-linked N-glycolylneuraminic acid, while not losing the ability to bind glycans having ?2-3-linked N-glycolylneuraminic acid.

Abstract: A shutoff switch for dispensing mixed beverages is presented. The shutoff switch includes a syrup inlet receiving syrup and a syrup outlet dispensing the syrup to a pump. The shutoff switch also includes a water inlet receiving water, and a water outlet dispensing the water to a either the pump or a dispensing point. Two distinct inlets and outlets for syrup and water prevent the syrup and water being mixed in the shutoff switch. The shutoff switch further includes a pressure responsive member that deforms based on pressure changes in the shutoff switch. When the deformation of the pressure responsive member reaches a threshold, an electrical gate in direct communication with the pressure responsive member opens, turning of a pump of the beverage dispensing system. Valves in either chamber of the shutoff switch can also be used as a redundant mechanical way to stop flow in the system.