Patents by Inventor James Clifford Sutton

James Clifford Sutton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections
    Patent number: 11912715
    Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
    Type: Grant
    Filed: July 13, 2021
    Date of Patent: February 27, 2024
    Assignee: Novartis AG
    Inventors: Rama Jain, Dennis Christofer Koester, James R. Manning, Vanessa Marx, Daniel Poon, James Clifford Sutton, Benjamin R. Taft, Lifeng Wan, Aregahegn Yifru, Qian Zhao
  • Dihydrothieno[3,2-b]pyridine compounds
    Patent number: 11584755
    Abstract: Compounds are provided having Formula (I): wherein R, R1, Cyc and A have the meanings provided herein. The compounds have utility in the treatment of diseases, either alone or in combination with other agents.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: February 21, 2023
    Assignee: IDEAYA BIOSCIENCES, INC.
    Inventors: Hilary Plake Beck, Leah Brigit Cleary, Michael Patrick Dillon, Marcos Gonzalez-Lopez, Luis Ruben P. Martinez, James Clifford Sutton, Jr.
  • AhR MODULATORS
    Publication number: 20230039955
    Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2e and R2d have the meanings provided in the specification.
    Type: Application
    Filed: June 29, 2022
    Publication date: February 9, 2023
    Inventors: Muzaffar ALAM, Hilary Plake BECK, Michael Patrick DILLON, Marcos GONZALEZ-LOPEZ, James Clifford SUTTON, JR.
  • Amido compounds as AhR modulators
    Patent number: 11548867
    Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: January 10, 2023
    Assignee: IDEA YA BIOSCIENCES, INC.
    Inventors: Muzaffar Alam, Hilary Plake Beck, Michael Patrick Dillon, Marcos Gonzalez-Lopez, Alice Chen Rico, James Clifford Sutton, Jr.
  • Substituted imidazo[1,5-a]pyrazines and [1,2,4]triazolo[4,3-a]pyrazines for the modulation of AhR
    Patent number: 11530220
    Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formula: wherein the letters and symbols a, b, c, d, e, f, A, R1, X1, Ar1 and Ar2 have the meanings provided in the specification.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: December 20, 2022
    Assignee: IDEAYA BIOSCIENCES, INC.
    Inventors: Hilary Plake Beck, Marcos Gonzalez-Lopez, James Clifford Sutton, Jr.
  • 4-SUBSTITUTED INDOLE AND INDAZOLE SULFONAMIDO DERIVATIVES AS PARG INHIBITORS
    Publication number: 20220389003
    Abstract: Provided herein are compounds having the formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, Ar, X1, X2, and ring B have the meanings as provided herein. The provided compounds are useful Poly ADP-ribose glycohydrolase (PARG) inhibitors.
    Type: Application
    Filed: September 18, 2020
    Publication date: December 8, 2022
    Inventors: James Clifford SUTTON, Jr., Michael Patrick Dillon
  • METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING AMIDO COMPOUNDS
    Publication number: 20220340875
    Abstract: Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae: wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.
    Type: Application
    Filed: July 18, 2019
    Publication date: October 27, 2022
    Inventors: Muzaffar ALAM, Fred ASWAD, Hilary Plake BECK, Michael Patrick DILLON, Marcos GONZALEZ-LOPEZ, Yujiro HATA, Alice Chen RICO, James Clifford SUTTON, Jr.
  • Tricyclic compounds useful to treat orthomyxovirus infections
    Patent number: 11453677
    Abstract: The present invention provides a compound of Formula (I) including pharmaceutically acceptable salts thereof: (I) and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions to treat viral infections.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: September 27, 2022
    Assignee: Novartis AG
    Inventors: Rama Jain, Dennis Christofer Koester, James R. Manning, James Clifford Sutton, Benjamin Robert Taft, Lifeng Wan, Qian Zhao
  • AhR modulators
    Patent number: 11407764
    Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: August 9, 2022
    Assignee: IDEAYA BIOSCIENCES, INC.
    Inventors: Muzaffar Alam, Hilary Plake Beck, Michael Patrick Dillon, Marcos Gonzalez-Lopez, James Clifford Sutton, Jr.
  • DIHYDROTHIENO[3,2-b]PYRIDINE COMPOUNDS
    Publication number: 20220227780
    Abstract: Compounds are provided having Formula (I): wherein R, R1, Cyc and A have the meanings provided herein. The compounds have utility in the treatment of diseases, either alone or in combination with other agents.
    Type: Application
    Filed: September 25, 2018
    Publication date: July 21, 2022
    Inventors: Hilary Plake BECK, Leah Brigit CLEARY, Michael Patrick DILLON, Marcos GONZALES-LOPEZ, Luis Ruben P. MARTINEZ, James Clifford SUTTON
  • Fused Tricyclic Pyridazinone Compounds Useful to Treat Orthomyxovirus Infections
    Publication number: 20220041610
    Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
    Type: Application
    Filed: July 13, 2021
    Publication date: February 10, 2022
    Inventors: Rama JAIN, Dennis Christofer KOESTER, James R. MANNING, Vanessa MARX, Daniel POON, James Clifford SUTTON, Benjamin R. TAFT, Lifeng WAN, Aregahegn YIFRU, Qian ZHAO
  • Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections
    Patent number: 11098051
    Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: August 24, 2021
    Assignee: Novartis AG
    Inventors: Rama Jain, Dennis Christofer Koester, James R. Manning, Vanessa Marx, Daniel Poon, James Clifford Sutton, Benjamin Robert Taft, Lifeng Wan, Aregahegn Yifru, Qian Zhao
  • METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING LACTAM COMPOUNDS
    Publication number: 20210254006
    Abstract: Provided are methods for expanding stem cells and/or lineage committed progenitor cells, at least in part, by using lactam compounds that antagonize AhR. The compounds are represented by formula (I): wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided below. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.
    Type: Application
    Filed: June 5, 2019
    Publication date: August 19, 2021
    Inventors: Muzaffar ALAM, Fred ASWAD, Hilary Plake BECK, Michael Patrick DILLON, Marcos GONZALEZ-LOPEZ, Yujiro HATA, James Clifford SUTTON, Jr.
  • AMIDO COMPOUNDS AS AhR MODULATORS
    Publication number: 20210115016
    Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.
    Type: Application
    Filed: July 18, 2018
    Publication date: April 22, 2021
    Inventors: Muzaffar ALAM, Hilary Plake BECK, Michael Patrick DILLON, Marcos GONZALEZ-LOPEZ, Alice Chen RICO, James Clifford SUTTON, Jr.
  • COMPOUNDS AND METHODS FOR THE MODULATION OF AHR
    Publication number: 20210079001
    Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formula: wherein the letters and symbols a, b, c, d, e, f, A, R1, X1, Ar1 and Ar2 have the meanings provided in the specification.
    Type: Application
    Filed: February 5, 2019
    Publication date: March 18, 2021
    Inventors: Hilary Plake BECK, Marcos GONZALEZ-LOPEZ, James Clifford SUTTON, JR.
  • AhR MODULATORS
    Publication number: 20210002297
    Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.
    Type: Application
    Filed: September 17, 2020
    Publication date: January 7, 2021
    Inventors: Muzaffar ALAM, Hilary Plake BECK, Michael Patrick DILLON, Marcos GONZALEZ-LOPEZ, James Clifford SUTTON, JR.
  • Tricyclic compounds useful to treat orthomyxovirus infections
    Patent number: 10858366
    Abstract: The present invention provides a compound of Formula (I) including pharmaceutically acceptable salts thereof: and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions to treat viral infections.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: December 8, 2020
    Assignee: Novartis AG
    Inventors: Rama Jain, Dennis Christofer Koester, James R. Manning, James Clifford Sutton, Benjamin Robert Taft, Lifeng Wan, Qian Zhao
  • Tricyclic Compounds Useful to Treat Orthomyxovirus Infections
    Publication number: 20200347072
    Abstract: The present invention provides a compound of Formula (I) including pharmaceutically acceptable salts thereof: (I) and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions to treat viral infections.
    Type: Application
    Filed: July 20, 2020
    Publication date: November 5, 2020
    Inventors: Rama JAIN, Dennis Christofer KOESTER, James R. MANNING, James Clifford SUTTON, Benjamin Robert TAFT, Lifeng WAN, Qian ZHAO
  • AhR modulators
    Patent number: 10815250
    Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: October 27, 2020
    Assignee: IDEAYA BIOSCIENCES, INC.
    Inventors: Muzaffar Alam, Hilary Plake Beck, Michael Patrick Dillon, Marcos Gonzalez-Lopez, James Clifford Sutton, Jr.
  • FUSED TRICYCLIC PYRIDAZINONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS
    Publication number: 20200123167
    Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
    Type: Application
    Filed: August 25, 2017
    Publication date: April 23, 2020
    Inventors: Rama JAIN, Dennis Christofer KOESTER, James R. MANNING, Vanessa MARX, Daniel POON, James Clifford SUTTON, Benjamin Robert TAFT, Lifeng WAN, Aregahegn YIFRU, Qian ZHAO