Abstract: Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: The methods of the present invention involve the novel use of the credit represented by a valid credit card and the processes of a Payment Network, enabling the credit card holder (CCH) to obtain relatively small, short-term funds at a significantly lower cost than traditionally associated with such funding.

Abstract: Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Apparatuses and computer-implemented methods are presented for discovering career and job opportunities that are categorized within one or more taxonomies having hierarchical categories. A taxonomy selection mechanism may be provided to enable user selection of one of multiple taxonomies for navigation. A taxonomic node network is rendered on a first portion of a user computing device display screen. The taxonomic node network includes elements corresponding to categories within the selected taxonomy, with the elements being animated for dynamic redistribution around a selected one of the network elements. Another portion of the user computing device display screen is automatically updated to display indicia of job opportunities categorized within a taxonomy category associated with the selected network element.

Abstract: Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Apparatuses and computer-implemented methods are presented for discovering career and job opportunities that are categorized within one or more taxonomies having hierarchical categories. A taxonomy selection mechanism may be provided to enable user selection of one of multiple taxonomies for navigation. A taxonomic node network is rendered on a first portion of a user computing device display screen. The taxonomic node network includes elements corresponding to categories within the selected taxonomy, with the elements being animated for dynamic redistribution around a selected one of the network elements. Another portion of the user computing device display screen is automatically updated to display indicia of job opportunities categorized within a taxonomy category associated with the selected network element.

Abstract: A communication system comprising a base station and two or more terminals configured for communicating with the base station by means of a communications protocol, wherein: the communications protocol operates in a frequency band to which unlicensed access is permitted; and the terminals are configured for unattended operation with the base station.

Abstract: A frequency shifter configured to shift the frequency of a signal, the frequency shifter comprising: a resonant structure configured to mechanically resonate at a first frequency; and a plurality of capacitors, each capacitor having a variable plate separation distance, wherein the resonant structure is configured to cause the plate separation distance of each capacitor to oscillate so as to cause the frequency of the signal to shift by the first frequency.

Abstract: A frequency shifter configured to shift the frequency of a signal, the frequency shifter comprising: a resonant structure configured to mechanically resonate at a first frequency; and a plurality of capacitors, each capacitor having a variable plate separation distance, wherein the resonant structure is configured to cause the plate separation distance of each capacitor to oscillate so as to cause the frequency of the signal to shift by the first frequency.

Abstract: A communication system comprising a base station and two or more terminals configured for communicating with the base station by means of a communications protocol, wherein: the communications protocol operates in a frequency band to which unlicensed access is permitted; and the terminals are configured for unattended operation with the base station.

Abstract: A frequency shifter configured to shift the frequency of a signal, the frequency shifter comprising: a resonant structure configured to mechanically resonate at a first frequency; and a plurality of capacitors, each capacitor having a variable plate separation distance, wherein the resonant structure is configured to cause the plate separation distance of each capacitor to oscillate so as to cause the frequency of the signal to shift by the first frequency.

Abstract: A frequency shifter configured to shift the frequency of a signal, the frequency shifter comprising: a resonant structure configured to mechanically resonate at a first frequency; and a plurality of capacitors, each capacitor having a variable plate separation distance, wherein the resonant structure is configured to cause the plate separation distance of each capacitor to oscillate so as to cause the frequency of the signal to shift by the first frequency.