Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

Abstract: Provided are spacers, ion-exchange devices comprising spacers, and methods of preparing spacers for improved fluid distribution and sealing throughout an ion-exchange device. These spacers can include an internal cavity surrounded by a perimeter of the spacer. The perimeter can have a first opening and a second opening within the perimeter, and the first opening and the second opening can be located on opposite sides of the internal cavity. The spacers can also have a first and second plurality of channels located within the perimeter, wherein each channel of the first and second plurality of channels extends from the internal cavity towards the first opening or the second opening.

Abstract: The present disclosure is directed ion-exchange systems and devices that include composite ion-exchange membranes having 3D printed spacers on them. These 3D printed spacers can drastically reduce the total intermembrane spacing within the system/device while maintaining a reliable sealing surface around the exterior border of the membrane. By adding the spacers directly to the membrane using additive manufacturing, the amount of material used can be reduced without adversely impacting the manufacturability of the composite membrane as well as allow for complex spacer geometries that can reduce the restrictions to flow resulting in less pressure drop associated with the flow in the active area of the membranes.

Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

Abstract: Provided are spacers, ion-exchange devices comprising spacers, and methods of preparing spacers for improved fluid distribution and sealing throughout an ion-exchange device. These spacers can include an internal cavity surrounded by a perimeter of the spacer. The perimeter can have a first opening and a second opening within the perimeter, and the first opening and the second opening can be located on opposite sides of the internal cavity. The spacers can also have a first and second plurality of channels located within the perimeter, wherein each channel of the first and second plurality of channels extends from the internal cavity towards the first opening or the second opening.

Abstract: Provided are hybrid electrochemical and membrane-based systems for removing silica from water stream to achieve ultra-pure water. The silica concentration of a feed water stream may dictate the most effective and economical variation of disclosed hybrid processes to use. For example, for a feed water stream having a silica concentration of 1-30 ppm, a hybrid system for treating the feed water includes an electrodialysis reversal unit, the electrodialysis reversal unit comprising an inlet stream and a product outlet stream; a reverse osmosis unit, the reverse osmosis unit comprising an inlet stream and a product outlet stream, wherein the inlet stream of the reverse osmosis unit comprises the product outlet stream of the electrodialysis reversal unit; and an electrodeionization unit, the electrodeionization unit comprising an inlet stream and a product outlet stream, wherein the inlet stream of the electrodeionization unit comprises the product outlet stream of the reverse osmosis unit.

Abstract: A string includes a pipe that is connected to an expansion mechanism and a retrieval tool that is connected to the pipe above the expansion mechanism. The retrieval tool includes a carrier that can selectively latch on an expandable liner and one or more actuators. The retrieval tool can ensure latching of the carrier while the expandable liner is above the Blow-out Preventer. The retrieval tool can prevent accidental latching of the carrier on the expandable liner during the expansion of the liner. By manipulating the pipe, the retrieval tool can force the carrier's release from the expandable liner.

Abstract: The present disclosure is directed ion-exchange systems and devices that include composite ion-exchange membranes having 3D printed spacers on them. These 3D printed spacers can drastically reduce the total intermembrane spacing within the system/device while maintaining a reliable sealing surface around the exterior border of the membrane. By adding the spacers directly to the membrane using additive manufacturing, the amount of material used can be reduced without adversely impacting the manufacturability of the composite membrane as well as allow for complex spacer geometries that can reduce the restrictions to flow resulting in less pressure drop associated with the flow in the active area of the membranes.

Abstract: Provided are spacers, ion-exchange devices comprising spacers, and methods of preparing spacers for improved fluid distribution and sealing throughout an ion-exchange device. These spacers can include an internal cavity surrounded by a perimeter of the spacer. The perimeter can have a first opening and a second opening within the perimeter, and the first opening and the second opening can be located on opposite sides of the internal cavity. The spacers can also have a first and second plurality of channels located within the perimeter, wherein each channel of the first and second plurality of channels extends from the internal cavity towards the first opening or the second opening.

Abstract: A system and method for software verification provides a lifting dictionary for each desired computer architecture. The lifting dictionary is used to translate native machine language instructions into descriptive intermediate language instructions. Each descriptive intermediate language instruction is atomic, in that, each descriptive intermediate language instruction changes at most one state of the emulated system. An emulator then runs the descriptive intermediate language instructions with tools that show each change of state after each DIL is emulated.

Abstract: A pallet is taught having two openings on at least one side of the pallet, the two openings formed by a bisecting wall separating the openings. More specifically, at least one bisecting post creates a first opening and a second opening Each of the said first and second openings each have a convexly curved runner, said runner convexly curved along its width; and a concavely curved ceiling, said ceiling concavely curved along its width wherein the center point of the radius of the curved runner varies from the radius of the curved ceiling.

Abstract: A liner hanger is used for deploying a liner into a wellbore. The liner hanger includes a tubular body having a first end and a second end. The first end can include a connection to a liner. The second end can include a sealed connection to an operational pipe. The sealed connection can be releasable. An expansion tool attached to a work string can be used for suspending the liner hanger into the wellbore. At least a portion of the expandable pipe is radially expanded using the expansion tool. The radial expansion of the expandable pipe can cause compression of at least one seal member against a base casing.

Abstract: Provided are spacers, ion-exchange devices comprising spacers, and methods of preparing spacers for improved fluid distribution and sealing throughout an ion-exchange device. These spacers can include an internal cavity surrounded by a perimeter of the spacer. The perimeter can have a first opening and a second opening within the perimeter, and the first opening and the second opening can be located on opposite sides of the internal cavity. The spacers can also have a first and second plurality of channels located within the perimeter, wherein each channel of the first and second plurality of channels extends from the internal cavity towards the first opening or the second opening.

Abstract: Provided are spacers, ion-exchange devices comprising spacers, and methods of preparing spacers for improved fluid distribution and sealing throughout an ion-exchange device. These spacers can include an internal cavity surrounded by a perimeter of the spacer. The perimeter can have a first opening and a second opening within the perimeter, and the first opening and the second opening can be located on opposite sides of the internal cavity. The spacers can also have a first and second plurality of channels located within the perimeter, wherein each channel of the first and second plurality of channels extends from the internal cavity towards the first opening or the second opening.

Abstract: A liner hanger is used for deploying a liner into a wellbore. The liner hanger includes a tubular body having a first end and a second end. The first end can include a connection to a liner. The second end can include a sealed connection to an operational pipe. The sealed connection can be releasable. An expansion tool attached to a work string can be used for suspending the liner hanger into the wellbore. At least a portion of the expandable pipe is radially expanded using the expansion tool. The radial expansion of the expandable pipe can cause compression of at least one seal member against a base casing.

Abstract: Provided are spacers, ion-exchange devices comprising spacers, and methods of preparing spacers for improved fluid distribution and sealing throughout an ion-exchange device. These spacers can include an internal cavity surrounded by a perimeter of the spacer. The perimeter can have a first opening and a second opening within the perimeter, and the first opening and the second opening can be located on opposite sides of the internal cavity. The spacers can also have a first and second plurality of channels located within the perimeter, wherein each channel of the first and second plurality of channels extends from the internal cavity towards the first opening or the second opening.

Abstract: A string includes a pipe that is connected to an expansion mechanism and a retrieval tool that is connected to the pipe above the expansion mechanism. The retrieval tool includes a carrier that can selectively latch on an expandable liner and one or more actuators. The retrieval tool can ensure latching of the carrier while the expandable liner is above the Blow-out Preventer. The retrieval tool can prevent accidental latching of the carrier on the expandable liner during the expansion of the liner. By manipulating the pipe, the retrieval tool can force the carrier's release from the expandable liner.

Abstract: A method of reducing hydraulic shock in a BOP system including a pressure regulator having an input port and an output port, and a regulator piston that moves between an open and a closed position based on a change in hydraulic pressure applied to the regulator piston via a pilot port. The method includes initiating a function, and monitoring the state of the function as it is carried out to predict when the function nears the end of its cycle. The method also includes, when the function reaches a predetermined state, adjusting the hydraulic pressure on the regulator piston via the pilot port to gradually move the regulator piston between the open to the closed position to reduce fluid flow through the fluid path in a controlled manner to reduce hydraulic shock.

Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.