Abstract: The present invention relates to efficient synthetic processes useful in the preparation of Compound A, a BTK inhibitor of Formula (I): or a pharmaceutically acceptable salt thereof, including the preparation of intermediates used to make Compound A or a pharmaceutically acceptable salt thereof.

Abstract: An external medical device includes a first cartridge bay with a first cartridge port, a second cartridge bay with a second cartridge port, a fluid outlet in fluid communication with the first cartridge port, a fluid pump configured to deliver a therapeutic fluid from a fluid cartridge engaged with the first cartridge port through the fluid outlet in response to fluid outlet control signals, a fluid inlet in fluid communication with the second cartridge port, and a fluid control structure in fluid communication with the fluid inlet to control fluid flow through the fluid inlet.

Abstract: An external medical device includes a fluid inlet, an inlet valve in fluid communication with the fluid inlet to control fluid flow through the fluid inlet in response to fluid inlet control signals, a fluid outlet in fluid communication with a fluid reservoir, a fluid pump configured to deliver a therapeutic fluid from the fluid reservoir through the fluid outlet in response to fluid outlet control signals, a fluid sensor configured to monitor the therapeutic fluid between the fluid pump and the fluid outlet and further configured to output sensor data corresponding to a monitored condition of the therapeutic fluid, and a control module configured to receive the sensor data and output, based on the sensor data, the fluid inlet control signals to the inlet valve and the fluid outlet control signals to the fluid pump.

Abstract: An external medical device includes a fluid inlet, an inlet valve in fluid communication with the fluid inlet to control fluid flow through the fluid inlet in response to fluid inlet control signals, a fluid outlet in fluid communication with a fluid reservoir, a fluid pump configured to deliver a therapeutic fluid from the fluid reservoir through the fluid outlet in response to fluid outlet control signals, a fluid sensor configured to monitor the therapeutic fluid between the fluid pump and the fluid outlet and further configured to output sensor data corresponding to a monitored condition of the therapeutic fluid, and a control module configured to receive the sensor data and output, based on the sensor data, the fluid inlet control signals to the inlet valve and the fluid outlet control signals to the fluid pump.

Abstract: A method of controlling a neutral section operation of a train (14) including a lead locomotive (16) and at least one remote locomotive (12) in communication with the lead locomotive. The locomotives are electrically powered from respective electrical connections to a catenary (22) having at least one neutral section (26). The method includes sensing when a lead locomotive is proximate the neutral section of the catenary. The lead locomotive then commands the remote locomotive to perform a neutral section operation when the lead locomotive has traveled a distance equal to a distance (20) between the lead locomotive and the remote locomotive. The lead locomotive determines when to issue a neutral section command based on a speed of the lead locomotive and an elapsed time from when the lead locomotive senses its location proximate the neutral section.

Abstract: Method for controlling the level of tractive efforts in a train having a first locomotive at a head end of the train, constituting a lead locomotive, and a second locomotive positioned in the train behind the lead locomotive, constituting a remote locomotive, with the remote locomotive being configured to selectively operate in either of two modes of operation, such as a first mode in which the locomotive operates at a full tractive effort level of operation and a second mode in which the locomotive operates in a partial tractive effort level of operation producing a tractive effort which is less than the full tractive effort of the locomotive. The method allows selecting (e.g., at the lead locomotive) one of the two modes of operation for producing a level of tractive effort appropriate for conditions as the train moves along a length of track. The method further allows transmitting a signal indicative of the selected mode of operation from the lead locomotive to the remote locomotive.

Abstract: A locomotive (10) is operable in two or more distinct configurations, with the change in configuration being response to a configuration input signal (35). A locomotive configuration is represented by the set of end use device control signals (13) that are generated by the locomotive control systems (22) in response to the respective set of operational input values (27). For a given set of operational input values, a first set of end use device control signals is generated when a configuration input has a first value, and a second set of end use device control signals is generated when a configuration input has a second value. The configuration input variable may be responsive to the locomotive location, a wayside device signal, an operator action or the health of the locomotive, for example. Locomotive configuration changes may include peak horsepower rating, number of engine cylinders fueled, number of throttle notch settings, adhesion limits, mission priorities or emission profile, for example.