Patents by Inventor James Coughlin

James Coughlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10299800
    Abstract: In one embodiment, the present invention includes a method of alignment for resection of tissue including obtaining a surgical device comprising an alignment guide, a first guide structure and a second guide structure; securing the alignment guide to a bone, the alignment guide including a positioning block; placing the first guide structure onto the positioning block of the alignment guide; viewing a target location of a first resection plane on the bone using the first guide structure; adjusting the target location of the first resection plane by adjusting a position of the first guide structure; attaching the second guide structure to the first guide structure; viewing a target location of a second resection plane on the bone using the second guide structure; and adjusting the target location of the second resection plane by adjusting a position of the second guide structure.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: May 28, 2019
    Assignee: Stryker European Holdings I, LLC
    Inventors: Thomas Loring, Stephen G. Gilbert, Victor Chan, Chulho Pak, Michael Daniels, Greg Horton, James K. Deorio, Michael Coughlin, Keith Wapner
  • Patent number: 10011626
    Abstract: A method of preparing purified decitabine comprises mixing crude decitabine with solvent, such as dimethylacetamide, to form a solution or suspension and forming the purified decitabine from the solution or suspension. The forming step comprises adding an anti-solvent, such as ethanol, to the solution or suspension. The forming step may further comprise after adding ethanol to provide a mixture of dimethylacetamide and ethanol: cooling the mixture; isolating the solid decitabine present in the cooled mixture; and evaporating residual dimethylacetamide and ethanol from the solid decitabine to provide the purified decitabine. The mixture of dimethylacetamide and ethanol may be heated. The purification method preferably results in decitabine having a ratio of the ?-anomer of decitabine to the ?-anomer of decitabine of at least about 99.9:0.1.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: July 3, 2018
    Assignee: Johnson Matthey Public Limited Company
    Inventor: Daniel James Coughlin
  • Patent number: 9815844
    Abstract: Compositions comprising hydrocodone benzoic acid enol ester to form novel prodrugs including hydrocodone benzoic acid enol ester salts, and various polymorphs. Also provided are processes for the preparation of hydrocodone benzoic acid enol ester salts, and various polymorphs.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: November 14, 2017
    Assignee: KemPharm, Inc.
    Inventors: Brian W. Heinrich, Da-Ming Gou, Mahmoud Mirmehrabi, Bernhard Paul, Daniel James Coughlin
  • Publication number: 20160168182
    Abstract: A method of preparing purified decitabine comprises mixing crude decitabine with solvent, such as dimethylacetamide, to form a solution or suspension and forming the purified decitabine from the solution or suspension. The forming step comprises adding an anti-solvent, such as ethanol, to the solution or suspension. The forming step may further comprise after adding ethanol to provide a mixture of dimethylacetamide and ethanol: cooling the mixture; isolating the solid decitabine present in the cooled mixture; and evaporating residual dimethylacetamide and ethanol from the solid decitabine to provide the purified decitabine. The mixture of dimethylacetamide and ethanol may be heated. The purification method preferably results in decitabine having a ratio of the ?-anomer of decitabine to the ?-anomer of decitabine of at least about 99.9:0.1.
    Type: Application
    Filed: February 25, 2016
    Publication date: June 16, 2016
    Applicant: Johnson Matthey Public Limited Company
    Inventor: Daniel James COUGHLIN
  • Publication number: 20160039837
    Abstract: Compositions comprising hydrocodone benzoic acid enol ester to form novel prodrugs including hydrocodone benzoic acid enol ester salts, and various polymorphs. Also provided are processes for the preparation of hydrocodone benzoic acid enol ester salts, and various polymorphs.
    Type: Application
    Filed: March 10, 2014
    Publication date: February 11, 2016
    Applicant: Johnson Matthey Public Limited Company
    Inventors: Brian W. HEINRICH, Da-Ming GOU, Mahmoud MIRMEHRABI, Bernhard PAUL, Daniel James COUGHLIN
  • Publication number: 20140094598
    Abstract: A method of preparing purified decitabine comprises mixing crude decitabine with solvent, such as dimethylacetamide, to form a solution or suspension and forming the purified decitabine from the solution or suspension. The forming step comprises adding an anti-solvent, such as ethanol, to the solution or suspension. The forming step may further comprise after adding ethanol to provide a mixture of dimethylacetamide and ethanol: cooling the mixture; isolating the solid decitabine present in the cooled mixture; and evaporating residual dimethylacetamide and ethanol from the solid decitabine to provide the purified decitabine. The mixture of dimethylacetamide and ethanol may be heated. The purification method preferably results in decitabine having a ratio of the ?-anomer of decitabine to the ?-anomer of decitabine of at least about 99.9:0.1.
    Type: Application
    Filed: September 30, 2013
    Publication date: April 3, 2014
    Applicant: Johnson Matthey Public Limited Company
    Inventor: Daniel James Coughlin
  • Publication number: 20080154611
    Abstract: A method implemented on a mobile device that includes speech recognition functionality involves presenting to a user of the mobile device a voice-control interface that supports two types of commands at a common level of the interface, the two types of commands including a first type and a second type, the first type being command and control commands and the second type being search request commands. The method further involves: receiving an utterance from the user that corresponds to a command of either of the first type or the second type; recognizing the utterance; if the received utterance is a command of the first type, performing a corresponding command and control function; and if the received utterance is a command of the second type, generating a representation of a corresponding search request and then using the representation to request a search that is responsive to the search request.
    Type: Application
    Filed: February 12, 2007
    Publication date: June 26, 2008
    Applicant: VOICE SIGNAL TECHNOLOGIES, INC.
    Inventors: Gunnar Evermann, Daniel L. ROTH, Laurence S. GILLICK, James COUGHLIN
  • Publication number: 20080154870
    Abstract: Methods and systems for providing voice-mediated search capability to a mobile communications device involve receiving a signal from the mobile device that includes a representation of a spoken search request from a user of the mobile device, using speech recognition software to convert the search request into a text search request, extracting side information contained implicitly within the received signal, using the extracted side information to assign the user to a category, sending the text search request and the user category to content providers, receiving from the content providers content that is responsive to the text search request and the user category, and sending to the mobile device search results that are based on content from content providers. The methods and systems further involve sending searches and user categories to advertising providers, and sending advertisements returned by the advertising providers to the mobile device along with the search results.
    Type: Application
    Filed: February 12, 2007
    Publication date: June 26, 2008
    Applicant: VOICE SIGNAL TECHNOLOGIES, INC.
    Inventors: Gunnar Evermann, Daniel L. ROTH, Laurence S. GILLICK, James COUGHLIN
  • Publication number: 20080154608
    Abstract: A method implemented on a mobile device that includes speech recognition functionality involves: receiving an utterance that includes a search request from a user of the device; recognizing that the utterance includes a search request; sending a representation of the search request to a remote server over a wireless data connection; receiving information over the wireless data connection that is responsive to the search request; presenting the information on the mobile device; receiving an input from the user selecting an item present in the received information, the item identifying a remote resource; using the selected item to connect to the remote resource, the connection to the remote resource not involving the remote server; and sending to the remote server an indication that a connection was made to the resource identified by the selected item. The method further involves storing a log of the user's connection to remote resources and sending the log to the server.
    Type: Application
    Filed: February 12, 2007
    Publication date: June 26, 2008
    Inventors: Gunnar Evermann, Daniel L. ROTH, Laurence S. GILLICK, James Coughlin
  • Publication number: 20080153465
    Abstract: Methods and devices for providing a user of a mobile communications device with mobile voice-mediated search capability. The methods and devices involve receiving an utterance from a user of the mobile device, the utterance including a search request; using the speech recognition functionality to recognize that the utterance includes a search request; as a result of recognizing that the utterance includes a search request, establishing a wireless data connection to a remote server; sending a representation of the search request to the remote server over the wireless data connection; receiving search results that are responsive to the search request; and presenting the search results on the mobile device.
    Type: Application
    Filed: February 9, 2007
    Publication date: June 26, 2008
    Applicant: Voice Signal Technologies, Inc.
    Inventors: Gunnar Evermann, Daniel L. Roth, Laurence S. Gillick, James Coughlin
  • Publication number: 20080154612
    Abstract: A method implemented on a mobile device that includes speech recognition functionality involves: receiving an utterance from a user of the mobile device, the utterance including a spoken search request; recognizing that the utterance includes a spoken search request; sending a representation of the spoken search request to a remote server over a wireless data connection; receiving search results over the wireless data connection that are responsive to the search request; storing the results on the mobile device; receiving a subsequent search request; performing a subsequent search responsive to the subsequent search request to generate subsequent search results, the subsequent search including searching the stored search results; and presenting the subsequent results on the mobile device.
    Type: Application
    Filed: February 12, 2007
    Publication date: June 26, 2008
    Applicant: Voice Signal Technologies, Inc.
    Inventors: Gunnar Evermann, Daniel L. Roth, Laurence S. Gillick, James Coughlin
  • Patent number: 5690413
    Abstract: A safety light is provided which is removably securable to a marine safety vest. Marine safety vests commonly include a back panel and two front panels, each of which have a first side and a second side and at least one slot formed therein. The panels are connected by straps which are threaded through the slots. The safety light includes a lamp which is pivotally mounted to an outer surface of a first plate. A threaded shaft extends from the inner surface of the plate to extend through a slot of a front panel of a vest. A battery pack or other energy source is provided to power the lamp. A securing member is provided to be placed against the inner surface of the front panel and includes an internally threaded boss which receives the shaft of the first plate to secure the safety light to the vest.
    Type: Grant
    Filed: February 27, 1996
    Date of Patent: November 25, 1997
    Inventor: James Coughlin