Abstract: An apparatus for filling a wound can include an array of at least four truncated ellipsoids interconnected to define at least one fluid path through, for example perpendicular to, the array. The longest principal axis of each ellipsoid may be perpendicular to the array. Each truncated ellipsoid may be a spheroid and/or may include an approximately elliptical contact surface at each contact surface between two interconnected ellipsoids. Each fluid pathway may have four continuously-curved concave sides and may have a parallelogram-shaped cross-section with continuously-curved concave edges. A dressing may include the apparatus, a dressing layer coupled to the apparatus, a backing layer disposed over a surface of the dressing layer opposite the apparatus, and an attachment device disposed on at least a margin of the backing layer. Methods of treating various tissue sites using the apparatus or dressing with negative-pressure therapy are also disclosed.

Abstract: In one aspect, a dressing for transferring skin grafts from a donor site to a recipient site is disclosed, which comprises a substrate having a surface configured for contact with one or more epidermal skin grafts, a plurality of capture sites distributed across said substrate surface, wherein each of said capture sites is configured for capturing at least one epidermal skin graft, and a plurality of topographical features distributed over said substrate surface and coupled to at least one of said capture sites so as to provide at least one of inducing proliferation and facilitating migration of keratinocytes in the captured epidermal skin grafts to surrounding tissue.

Abstract: A method of manufacturing a tissue interface for a reduced pressure tissue treatment system is provided. The method includes foaming a plurality of polymer particles to form a porous polymer. The method also includes sintering the porous polymer to form a sintered porous polymer. The method further includes texturing the sintered porous polymer. A system to provide reduced pressure at a tissue site is provided. The system includes a cover configured to form a seal over the tissue site. The system also includes a reduced-pressure source configured to provide reduced pressure through the cover at the tissue site. The system further includes a tissue interface configured to be disposed underneath the cover at the tissue site and comprising a porous polymer that is formed from one or more polymer particles that may be foamed and textured.

Abstract: An apparatus for filling a wound can include an array of at least four truncated ellipsoids interconnected to define at least one fluid path through, for example perpendicular to, the array. The longest principal axis of each ellipsoid may be perpendicular to the array. Each truncated ellipsoid may be a spheroid and/or may include an approximately elliptical contact surface at each contact surface between two interconnected ellipsoids. Each fluid pathway may have four continuously-curved concave sides and may have a parallelogram-shaped cross-section with continuously-curved concave edges. A dressing may include the apparatus, a dressing layer coupled to the apparatus, a backing layer disposed over a surface of the dressing layer opposite the apparatus, and an attachment device disposed on at least a margin of the backing layer. Methods of treating various tissue sites using the apparatus or dressing with negative-pressure therapy are also disclosed.

Abstract: The present disclosure provides amine-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include a covalently attached molecule comprising free amine groups. Such amine groups can be used, for instance, to conjugate biologically active polypeptides and/or linkers. Methods for using modified polymers are also provided.

Abstract: Aptamer-modified polymers and materials thereof, used for binding factors in a wound bed. The aptamer-modified materials can be polypeptides conjugated to polymer foam materials and used, for example, as dressings, wound inserts, or pads.

Abstract: A method may include forming a mesh comprising a plurality of strands meshed together. Each of the plurality of strands may include a polymeric film. The method may include perforating the mesh to form a perforated mesh having one or more perforations. The method may further include texturing the perforated mesh to form at textured and perforated mesh having at least one of a dimple or a channel. A system may include a cover configured to form a seal over the tissue site. The system may also include a reduced-pressure source configured to provide reduced pressure through the cover at the tissue site. The system may further include a tissue interface configured to be disposed underneath the cover at the tissue site. The tissue interface may include a textured mat having a plurality of strands of polymeric film matted together and at least one of a dimple or a channel.

Abstract: A treatment system for applying negative-pressure therapy to a wound site is disclosed. The treatment system may include a non-adherent material for applying to the perimeter of the wound site. In some embodiments, the treatment system may include a tape, a tissue interface, a sealing member, and a negative-pressure subsystem. The tape material may provide a smooth surface along the perimeter of the wound site for protecting the wound edges from stresses and for promoting epithelialization.

Abstract: The present disclosure provides amine-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include a covalently attached molecule comprising free amine groups. Such amine groups can be used, for instance, to conjugate biologically active polypeptides and/or linkers. Methods for using modified polymers are also provided.

Abstract: The present disclosure provides amine-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include a covalently attached molecule comprising free amine groups. Such amine groups can be used, for instance, to conjugate biologically active polypeptides and/or linkers. Methods for using modified polymers are also provided.

Abstract: The present disclosure provides amine-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include a covalently attached molecule comprising free amine groups. Such amine groups can be used, for instance, to conjugate biologically active polypeptides and/or linkers. Methods for using modified polymers are also provided.

Abstract: The present disclosure provides amine-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include a covalently attached molecule comprising free amine groups. Such amine groups can be used, for instance, to conjugate biologically active polypeptides and/or linkers. Methods for using modified polymers are also provided.

Abstract: The present disclosure provides sulfhydryl-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include free sulfhydryl group, which can serve as a linker to attach biologically active molecules. For example, sulfhydryl groups can be used to conjugate biologically active polypeptides and/or metals to foam polymers. Methods for using sulfhydryl-modified polymers, such as for wound dressings, are also provided.

Abstract: Aptamer-modified polymers and materials thereof, used for binding factors in a wound bed. The aptamer-modified materials can be polypeptides conjugated to polymer foam materials and used, for example, as dressings, wound inserts, or pads.

Abstract: The present invention provides aptamer-modified polymers and materials thereof, which may be used for the binding of factors in a wound bed. For example, the aptamer-modified materials can be polypeptides conjugated to polymer foam materials. Such materials may be used, for example, for dressings, wound inserts, or pads.

Abstract: The present disclosure provides sulfhydryl-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include free sulfhydryl group, which can serve as a linker to attach biologically active molecules. For example, sulfhydryl groups can be used to conjugate biologically active polypeptides and/or metals to foam polymers. Methods for using sulfhydryl-modified polymers, such as for wound dressings, are also provided.

Abstract: The present disclosure provides amine-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include a covalently attached molecule comprising free amine groups. Such amine groups can be used, for instance, to conjugate biologically active polypeptides and/or linkers. Methods for using modified polymers are also provided.

Abstract: The present invention provides aptamer-modified polymers and materials thereof, which may be used for the binding of factors in a wound bed. For example, the aptamer-modified materials can be polypeptides conjugated to polymer foam materials. Such materials may be used, for example, for dressings, wound inserts, or pads.