Abstract: A method of providing therapeutic treatment by delivering therapeutic aptamers locally to a target site using microneedles includes providing complementary sequence modified microneedles by reacting a complementary sequence (CS) with a polymer thereby forming a covalent bond between the polymer and the CS, forming microneedle patches using an initial casting solution consisting of the polymer, the therapeutic aptamer, and a covalent bond between a complementary sequence (CS) and the polymer, thereby loading the therapeutic aptamer into the microneedles, each microneedle having a base, shaft and tip, physically binding the therapeutic aptamer to the CS, inserting the microneedles into the tissue such that the tips and shafts are embedded into the target site and the bases are on a surface of the target site, and sustained release of the aptamer to the target site due to dissociation of the aptamer from the CS over time.

Abstract: A headgear for magnetoencephalography includes a body defining a plurality of ports, where the body includes a first portion and a second portion; an adjustment mechanism coupled to the first portion and the second portion of the body and configured to adjust a separation between the first and second portion to facilitate fitting the headgear to a head of a user; and a plurality of optically pumped magnetometer (OPM) modules, where each of the OPM modules includes at least one vapor cell and is configured to be removably inserted into a one of the ports of the body, where each of the OPM modules is configured for coupling to a light source for receiving light.

Abstract: A method of providing therapeutic treatment by delivering therapeutic aptamers locally to a target site using microneedles includes providing complementary sequence modified microneedles by reacting a complementary sequence (CS) with a polymer thereby forming a covalent bond between the polymer and the CS, forming microneedle patches using an initial casting solution consisting of the polymer, the therapeutic aptamer, and a covalent bond between a complementary sequence (CS) and the polymer, thereby loading the therapeutic aptamer into the microneedles, each microneedle having a base, shaft and tip, physically binding the therapeutic aptamer to the CS, inserting the microneedles into the tissue such that the tips and shafts are embedded into the target site and the bases are on a surface of the target site, and sustained release of the aptamer to the target site due to dissociation of the aptamer from the CS over time.

Abstract: A system including a shuttle movable along a shuttle path, the shuttle being operable to support a sheet; a pick-up assembly including a yoke and a detection plate located above the shuttle path, the detection plate being freely supported by the yoke and movable in a vertical direction relative to the yoke with an upper limit and a lower limit defined by the yoke, wherein the yoke is operable to pick and place the sheet, and wherein the detection plate is used to detect the presence of a piece of debris on a surface of the sheet or a surface of the shuttle; and a cleaning device located adjacent to the pick-up assembly and above the shuttle path, wherein the cleaning device is operable to remove the piece of debris located on the surface of the sheet or the surface of the shuttle.