Abstract: Provided herein are biomimetic osteochondral implants that are generally useful for the at least partial resurfacing of damaged cartilage within a joint. The implants are constructed to have a modular, layered structure in which the physical properties (e.g., stiffness and lubricity) or dimensions of each layer can be adjusted (e.g., by using the appropriate material and controlling the thickness thereof) based on the anatomy to be replaced. For example, the material and or thicknesses of the layers can be selected to approximate the physical properties and/or dimensions of cartilage (and, optionally, chondral and subchondral bone). Also provided herein are methods of treatment involving the use of said biomimetic osteochondral implants to repair an osteochondral defect in a joint.

Abstract: Provided herein are biomimetic osteochondral implants that are generally useful for the at least partial resurfacing of damaged cartilage within a joint. The implants are constructed to have a modular, layered structure in which the physical properties (e.g., stiffness and lubricity) or dimensions of each layer can be adjusted (e.g., by using the appropriate material and controlling the thickness thereof) based on the anatomy to be replaced. For example, the material and or thicknesses of the layers can be selected to approximate the physical properties and/or dimensions of cartilage (and, optionally, chondral and subchondral bone). Also provided herein are methods of treatment involving the use of said biomimetic osteochondral implants to repair an osteochondral defect in a joint.

Abstract: Provided herein are biomimetic osteochondral implants that are generally useful for the at least partial resurfacing of damaged cartilage within a joint. The implants are constructed to have a modular, layered structure in which the physical properties (e.g., stiffness and lubricity) or dimensions of each layer can be adjusted (e.g., by using the appropriate material and controlling the thickness thereof) based on the anatomy to be replaced. For example, the material and or thicknesses of the layers can be selected to approximate the physical properties and/or dimensions of cartilage (and, optionally, chondral and subchondral bone). Also provided herein are methods of treatment involving the use of said biomimetic osteochondral implants to repair an osteochondral defect in a joint.

Abstract: A kit of patient-specific guides for use in preparing a proximal femur to receive a prosthesis is described, and includes patient-specific preparation guides. The femoral resection guide has a body including a proximal cut guide surface and a distal conforming surface contoured to rest against and substantially conform to a femoral neck and/or a metaphysis of the proximal femur. The proximal cut guide surface is configured to guide a cutting instrument for resecting the head of the proximal femur. The femoral canal preparation guide has a body including a proximal surface and a distal surface having a first confirming portion contoured to rest against and substantially conform to an unresected portion of a femoral neck and/or a metaphysis of the proximal femur. The body includes a guide aperture extending therethrough that is dimensioned to guide an instrument for preparing a canal of the proximal femur.

Abstract: Patient-specific instruments for preparing bones, such as a proximal femur and an acetabulum in a total hip arthroplasty, to receive respective orthopedic prostheses. The guides include a femoral resection guide and a bone canal preparation guide, each having a surface conforming to at least one of a metaphysis and a femoral neck of a femur. The femoral resection guide includes a cut referencing surface to guide a cutting instrument, and the bone canal preparation guide includes a guide aperture sized to guide a rasping instrument. An acetabular guide includes a surface conforming to an acetabulum and a guide aperture for guiding a surgical instrument such as a reaming instrument. The patient-specific, conforming surfaces of each of the guides may be designed based on patient-specific anatomical data obtained from the use of imaging technology.