Patents by Inventor James Crow
James Crow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12226471Abstract: The present invention relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof.Type: GrantFiled: May 1, 2023Date of Patent: February 18, 2025Assignees: The Trustees of the University of Pennsylvania, The Johns Hopkins University, Vanderbilt UniversityInventors: Drew Weissman, George M. Shaw, Justin R. Bailey, Stuart C. Ray, James Crowe, Jr., Andrew Flyak
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Publication number: 20240123050Abstract: The present invention relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof.Type: ApplicationFiled: May 1, 2023Publication date: April 18, 2024Inventors: Drew Weissman, George M. Shaw, Justin R. Bailey, Stuart C. Ray, James Crowe, Jr., Andrew Flyak
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Patent number: 11660332Abstract: The present invention relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof.Type: GrantFiled: April 27, 2018Date of Patent: May 30, 2023Assignees: The Trustees of the University of Pennsylvania, The Johns Hopkins University, Vanderbilt UniveisilyInventors: Drew Weissman, George M. Shaw, Justin R. Bailey, Stuart C. Ray, James Crowe, Jr., Andrew Flyak
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Publication number: 20200222528Abstract: The present invention relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof.Type: ApplicationFiled: April 27, 2018Publication date: July 16, 2020Inventors: Drew Weissman, George M. Shaw, Justin R. Bailey, Stuart C. Ray, James Crowe, Jr., Andrew Flyak
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Patent number: 10162166Abstract: The present disclosure provides devices, systems and methods for the acquisition and display of captured and/or saved slide images of a sample. In particular embodiments, the images are displayed on a portable computer attached to a removable device configured to hold a slide of the sample. The device is aligned with the portable computer so that the displayed sample image is overlaid with the sample being held by the device. In exemplary embodiments, the displayed image is used as a template for dissection of the sample being held by the device.Type: GrantFiled: October 28, 2015Date of Patent: December 25, 2018Assignee: MIKROSCAN TECHNOLOGIES, INC.Inventors: Victor Casas, James Crowe
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Patent number: 9111405Abstract: Vending Machines (VMs) employ a series of physical locks to prevent unauthorized access and/or control of the machine. In addition to the lock on the front door, in one embodiment of the invention an electrical door switch is employed that is used to enable a set of protected commands to the Vending Machine Controller Card (VMCC) only when the door has been opened. An electronic override of this switch, via remote control of a telemetry device (VIU) coupled to the VM, allows the VMCC to accept protected-mode commands from a central command server via a wireless network regardless of whether the door was actually opened. Other embodiments are described herein.Type: GrantFiled: November 15, 2012Date of Patent: August 18, 2015Assignee: Vendwatch Telematics, LLCInventors: Alfonso Barragan, Herb Rose, James Crow
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Publication number: 20150164834Abstract: The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: February 24, 2015Publication date: June 18, 2015Applicant: United Therapeutics CorporationInventors: Gilles Cloutier, James Crow, Michael Wade, Richard E. Parker, James E. Loyd
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Patent number: 9041242Abstract: A method of providing operating electrical power from a stationary power source to a mobile conveyor utilized in material handling at a mine site as the conveyor moves over a predetermined path at the site without having to move long lengths of cable as the conveyor moves away from the power source. The method utilizes a cable reel that features a power receptacle into which a cable connector can be easily plugged and unplugged.Type: GrantFiled: December 26, 2012Date of Patent: May 26, 2015Assignee: FLSMIDTH A/SInventor: James Crowe
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Publication number: 20140179154Abstract: A method of providing operating electrical power from a stationary power source to a mobile conveyor utilized in material handling at a mine site as the conveyor moves over a predetermined path at the site without having to move long lengths of cable as the conveyor moves away from the power source. The method utilizes a cable reel that features a power receptacle into which a cable connector can be easily plugged and unplugged.Type: ApplicationFiled: December 26, 2012Publication date: June 26, 2014Applicant: FLSMIDTH A/SInventor: James Crowe
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Publication number: 20140135980Abstract: Vending Machines (VMs) employ a series of physical locks to prevent unauthorized access and/or control of the machine. In addition to the lock on the front door, in one embodiment of the invention an electrical door switch is employed that is used to enable a set of protected commands to the Vending Machine Controller Card (VMCC) only when the door has been opened. An electronic override of this switch, via remote control of a telemetry device (VIU) coupled to the VM, allows the VMCC to accept protected-mode commands from a central command server via a wireless network regardless of whether the door was actually opened. Other embodiments are described herein.Type: ApplicationFiled: November 15, 2012Publication date: May 15, 2014Inventors: Alfonso Barragan, Herb Rose, James Crow
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Publication number: 20110135645Abstract: The present invention discloses methods for generating antibodies to human metapneumovirus (HMPV) polypeptides, including antibodies that immunospecifically bind to a HMPV F-protein. The invention also discloses methods for preventing, treating, or ameliorating symptoms associated with HMPV infection.Type: ApplicationFiled: October 4, 2007Publication date: June 9, 2011Applicant: The Scripps Research InstituteInventors: R. Anthony Williamson, Zhifeng Chen, Pietro Paolo Sanna, Dennis R. Burton, James Crowe, John V. Williams
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Publication number: 20090124697Abstract: The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: September 19, 2008Publication date: May 14, 2009Inventors: Gilles Cloutier, James Crow, Michael Wade, Richard E. Parker, James E. Loyd
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Publication number: 20070286873Abstract: The present invention provides an improved form of a nucleic acid encoding for the influenza hemagluttinin H5N1. The optimized gene sequence permits production via recombinant means, of the H5N1 HA protein for use in diagnostic assays and vaccines.Type: ApplicationFiled: May 23, 2007Publication date: December 13, 2007Inventors: John Williams, James Crowe
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Publication number: 20070269451Abstract: A nucleic acid vaccine construct comprising an isolated polynucleotide which encodes a polypeptide comprising at least five consecutive amino acid residues from the VNTR monomer of Muc1 wherein one or more of said amino acids is a glycosylation site, characterised in that when said isolated polynucleotide is expressed in a mammalian cell, glycosylation of the resulting polypeptide is altered or prevented at at least one of said glycosylation sites.Type: ApplicationFiled: November 2, 2006Publication date: November 22, 2007Inventors: James Crowe, Jonathan Ellis
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Publication number: 20070028414Abstract: A road sweeper includes a blower housing having an opening, a hopper having an opening, and the openings being in axial alignment when the hopper and blower housing are each in a sweeping position thereof. The blower housing is biased for tilting movement from its sweeping position to an inclined dump position upon relative movement of the hopper to preclude abrasion, wear and damage to an O-ring seal disposed between the openings. The blower housing can also be moved to a third repair position in which components thereof are accessible from the cab side of the sweeper.Type: ApplicationFiled: August 8, 2005Publication date: February 8, 2007Inventors: Gary Young, James Crow
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Publication number: 20060173765Abstract: A method and computer program product are presented for selecting and arranging an appropriate combination of network components, or elements, in a communications network. The selection of network components is done in a manner that maximizes the net present value of cash flow resulting from the provision of communications services between nodes of the network. The method comprises the steps of receiving information that constrains network design and price establishment, and then using the constraint information to select a combination of network components for each link in the communications network. According to the invention, the selection of network components is performed for each of several successive time periods, effectively planning the evolution of the network. The selections are made so that the network components satisfy demand over time while maximizing the net present value of the cash flow that results from the provision of communications services.Type: ApplicationFiled: March 20, 2006Publication date: August 3, 2006Inventors: James Crowe, Russell Rushmeier, Indraneel Das, Paul Koster, Jose Alvarez, Mark Reynolds, Lorraine Lotosky
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Publication number: 20050260216Abstract: The present invention relates to an isolated polypeptide useful for immunisation against self-antigens. In particular the invention relates to a self-protein that is capable of raising auto-antibodies when administered in vivo. The invention particularly relates to rendering human cytokines immunogenic in humans. The invention further relates to pharmaceutical compositions comprising such compounds and their use in medicine and to methods for their production.Type: ApplicationFiled: March 1, 2002Publication date: November 24, 2005Inventors: Claire Ashman, James Crowe, Jonathan Ellis, Alan Lewis
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Publication number: 20050186209Abstract: The present invention relates to an isolated polypeptide useful for immunisation against self-antigens. In particular the invention relates to a self-protein that is capable of raising auto-antibodies when administered in vivo. The invention particularly relates to rendering human cytokines immunogenic in humans. The invention further relates to pharmaceutical compositions comprising such compounds and their use in medicine and to methods for their production.Type: ApplicationFiled: January 24, 2005Publication date: August 25, 2005Inventors: Claire Ashman, James Crowe, Jonathan Ellis, Alan Lewis
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Patent number: 6756033Abstract: A method of delivering benzindene prostaglandins to a patient by inhalation is discussed. A benzindene prostaglandin known as UT-15 has unexpectedly superior results when administered by inhalation compared to parenterally administered UT-15 in sheep with induced pulmonary hypertension.Type: GrantFiled: August 6, 2002Date of Patent: June 29, 2004Assignee: United Therapeutics CorporationInventors: Gilles Cloutier, James Crow, Michael Wade, Richard E. Parker, James E. Loyd
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Patent number: 6688313Abstract: An electrical smoking system comprising a cigarette and an electric lighter, wherein the cigarette comprises a tubular tobacco mat partially filled with material tobacco so as to define a filled tobacco rod portion and an unfilled tobacco rod portion. The cigarette and the lighter are mutually arranged so that when the cigarette is received in the lighter, the electrical heater element of the lighter at least partially superposes at least a portion of the filled tobacco rod portion. The cigarette and the lighter are also mutually arranged so that when the cigarette is received in the lighter, the free end of the cigarette is occluded. The cigarette includes a zone of perforations at a location along the filled tobacco rod portion, with the cigarette being free of perforations along the unfilled tobacco rod portion. An apparatus for perforating a cigarette which can be smoked in an electrical smoking device includes a drum link-up assembly and a laser perforating apparatus.Type: GrantFiled: March 23, 2001Date of Patent: February 10, 2004Assignee: Philip Morris IncorporatedInventors: Susan E. Wrenn, A. Clifton Lilly, Jr., Traci L. Franklin, Patrick H. Hayes, Mary Ellen Counts, William James Crowe