Patents by Inventor James D. Bergstrom

James D. Bergstrom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying compounds useful for inhibiting farnesyl diphosphate synthase
    Publication number: 20040235797
    Abstract: The present invention relates to methods for identifying compounds useful as inhibitors of farnesyl diphosphate synthase. More particularly, the compounds so identified are useful for inhibiting bone resorption. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of a farnesyl diphosphate synthase inhibitor.
    Type: Application
    Filed: June 25, 2004
    Publication date: November 25, 2004
    Inventors: James D. Bergstrom, Alfred A. Reszka, Gideon A. Rodan
  • Methods for identifying compounds useful for inhibiting farnesyl diphosphate synthase
    Publication number: 20020151459
    Abstract: The present invention relates to methods for identifying compounds useful as inhibitors of farnesyl diphosphate synthase. More particularly, the compounds so identified are useful for inhibiting bone resorption. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of a farnesyl diphosphate synthase inhibitor.
    Type: Application
    Filed: April 11, 2002
    Publication date: October 17, 2002
    Applicant: Merck & Co., Inc.
    Inventors: James D. Bergstrom, Alfred A. Reszka, Gideon A. Rodan
  • Cholesterol lowering compounds
    Patent number: 5506262
    Abstract: Disclosed herein are compounds of structural formula (I) ##STR1## which are useful as cholesterol lowering agents. These compounds are also useful as inhibitors of squalene synthetase, inhibitors of fungal growth, inhibitors of farnesyl-protein transferase and farnesylation of the oncogene protein Ras. These compounds are also useful in the treatment of cancer.
    Type: Grant
    Filed: November 10, 1993
    Date of Patent: April 9, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Robert M. Burk, William H. Parsons, John J. Acton, III, Gregory D. Berger, Tesfaye Biftu, Robert L. Bugianesi, Yuan-Ching P. Chiang, Claude Dufresne, Narindar N. Girotra, Robert W. Marquis, Jr., Chan-Hwa Kuo, Sandra P. Plevyak, Mitree M. Ponpipom, Lori L. Whiting, James D. Bergstrom, Conrad Santini
  • Cholesterol-lowering agents
    Patent number: 5369125
    Abstract: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer.
    Type: Grant
    Filed: March 19, 1993
    Date of Patent: November 29, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Gregory D. Berger, James D. Bergstrom, Tesfaye Biftu, Robert L. Bugianesi, Robert M. Burk, Narindar N. Girotra, C. H. Kuo, William H. Parsons, Mitree M. Ponpipom, Lori L. Whiting
  • Squalene synthetase inhibitors
    Patent number: 5135935
    Abstract: Compounds of structural formula (I): ##STR1## are squalene synthestase inhibitors useful in inhibiting the biosynthesis of cholesterol in the treatment of hypercholesterolemia and related disorders.
    Type: Grant
    Filed: May 17, 1991
    Date of Patent: August 4, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Alfred W. Alberts, Gregory D. Berger, James D. Bergstrom
  • Squalene synthetase inhibitors
    Patent number: 5132320
    Abstract: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: July 21, 1992
    Assignee: Merck & Co., Inc.
    Inventors: James D. Bergstrom, Otto D. Hensens, Claude Dufresne, Leeyuan Huang, Janet C. Onishi, Deborah L. Zink
  • Novel squalene synthetase inhibitors
    Patent number: 5102907
    Abstract: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: April 7, 1992
    Assignee: Merck & Co., Inc.
    Inventors: James D. Bergstrom, Claude Dufresne, Leeyuan Huang, Mary Nallin, Janet C. Onishi
  • Novel squalene synthetase inhibitors
    Patent number: 5096923
    Abstract: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: March 17, 1992
    Assignee: Merck & Co., Inc.
    Inventors: James D. Bergstrom, Otto D. Hensens, Leeyuan Huang, Jerrold M. Liesch, Janet C. Onishi, Frank L. Vanmiddlesworth