Abstract: The present application describes stapled peptide degron chimeras, which act as protein degradation inducing moieties, either by combining a stapled peptide that binds a disease-related protein with a small molecule degron, such as a cereblon- or VHL-binding small molecule as the degron, or a polypeptide sequence degron, such as a Cop1-binding Trib peptide as the degron; or by combining a stapled peptide degron with a peptide, such as a stapled peptide, or a small molecule that binds a disease-related protein. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of stapled peptide degron chimeras which can be utilized in the treatment of proliferative disorders or other conditions whereby elimination of a disease-causing or disease-related protein would have a therapeutic benefit. The present application also provides methods for making compounds of the application and intermediates thereof.

Abstract: A latch assembly for connecting a hood assembly to a truck includes a striker bolt that is surrounded by a sleeve that is engaged by a rotary latch. The sleeve is of shorter length than the striker bolt so that it can slide along the striker bolt. The rotary latch fixedly engages the sleeve so that any relative motion between the hood and frame translates to movement of the sleeve along the striker bolt rather than between the rotary latch and striker bolt. The sleeve arrangement thus provides wear protection to rotary latch, allows for self alignment of the hood and fender assembly along the striker bolt axis and dynamic movement of the latch during vehicle operation.