Patents by Inventor James D. Buchner

James D. Buchner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11059017
    Abstract: A method for process monitoring and control of a chemical reactor in which a chemical reaction utilizing a halogenated selectivity modifier is performed includes: measuring a level of halogenated components in an inlet stream of a reactor inlet; measuring a level of halogenated components in an outlet stream of a reactor outlet; based on the level of halogenated components at the inlet stream and the outlet stream, determining a process performance indicator associated with a halogenated component; and adjusting an amount of halogenated selectivity modifier added to the reactor based on the process performance indicator.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: July 13, 2021
    Assignee: MultiPhase Solutions, Inc.
    Inventors: James D. Buchner, Sr., James D. Buchner, Jr.
  • Publication number: 20210041420
    Abstract: Cell and organ (or tissue) cultures provide a micro-environment with respect to nutrients, gas exchange, and scaffolding in order to encourage specific cell function, and in some cases to mimic in-vivo cellular expression under in-vitro conditions. We describe apparatus and methods to chemically, spatially, and temporally measure diffusible molecules produced, or used by cells or tissues in culture. In this manner, mechanisms of cell-cell interaction and other chemical signaling, detailed biochemical pathways, and the action of potential pharmaco-therapy agents can be better understood at a molecular level. In addition to basic science, the technical advantages of process monitoring and control can be applied to optimize culture products in bioreactors. Embodiments of this device are intended to simulate and monitor [input and output] the behavior of vascular capillary beds in higher species vascular systems.
    Type: Application
    Filed: October 26, 2020
    Publication date: February 11, 2021
    Inventors: James D. Buchner, Ross C. Willoughby
  • Patent number: 10852296
    Abstract: Cell and organ (or tissue) cultures provide a micro-environment with respect to nutrients, gas exchange, and scaffolding in order to encourage specific cell function, and in some cases to mimic in-vivo cellular expression under in-vitro conditions. We describe apparatus and methods to chemically, spatially, and temporally measure diffusible molecules produced, or used by cells or tissues in culture. In this manner, mechanisms of cell-cell interaction and other chemical signaling, detailed biochemical pathways, and the action of potential pharmaco-therapy agents can be better understood at a molecular level. In addition to basic science, the technical advantages of process monitoring and control can be applied to optimize culture products in bioreactors. Embodiments of this device are intended to simulate and monitor [input and output] the behavior of vascular capillary beds in higher species vascular systems.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: December 1, 2020
    Assignee: BiOMICom Incorporated
    Inventors: James D. Buchner, Ross C. Willoughby
  • Publication number: 20190083951
    Abstract: A method for process monitoring and control of a chemical reactor in which a chemical reaction utilizing a halogenated selectivity modifier is performed includes: measuring a level of halogenated components in an inlet stream of a reactor inlet; measuring a level of halogenated components in an outlet stream of a reactor outlet; based on the level of halogenated components at the inlet stream and the outlet stream, determining a process performance indicator associated with a halogenated component; and adjusting an amount of halogenated selectivity modifier added to the reactor based on the process performance indicator.
    Type: Application
    Filed: September 14, 2018
    Publication date: March 21, 2019
    Inventors: James D. Buchner, Sr., James D. Buchner, Jr.
  • Patent number: 9719890
    Abstract: The current invention describes in vivo and vitro (cultured) sampling technologies that allow direct temporal and spatial sampling from living ecosystems such as those associated with marine ecology. The optional use of parallel sampling methods, observatory design, provides for the ability to measure the response of individual organisms to a variety of both biotic and abiotic stresses. Sampling in small volumes and close proximity to living organisms has allowed direct measurement of various invertebrate and other aquatic species in marine ecosystems. These sampling techniques are intended to apply to any liquid based ecosystem in an attempt to minimize sampling as a dependent variable in measuring the chemical and biological behavior of the ecosystem. If is intended that this sampling technology be used to directly measure the chemical behavior of a wide variety of organisms; including, plants, animals, and micro-organisms (e.g. algae, plankton).
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: August 1, 2017
    Assignee: BIOMICOM INCORPORATED
    Inventors: James D Buchner, Ross C Willoughby
  • Publication number: 20170097286
    Abstract: The current invention describes in vivo and vitro (cultured) sampling technologies that allow direct temporal and spatial sampling from living ecosystems such as those associated with marine ecology. The optional use of parallel sampling methods, observatory design, provides for the ability to measure the response of individual organisms to a variety of both biotic and abiotic stresses. Sampling in small volumes and close proximity to living organisms has allowed direct measurement of various invertebrate and other aquatic species in marine ecosystems. These sampling techniques are intended to apply to any liquid based ecosystem in an attempt to minimize sampling as a dependent variable in measuring the chemical and biological behavior of the ecosystem. If is intended that this sampling technology be used to directly measure the chemical behavior of a wide variety of organisms; including, plants, animals, and micro-organisms (e.g. algae, plankton).
    Type: Application
    Filed: May 24, 2013
    Publication date: April 6, 2017
    Inventors: James D. Buchner, Ross C. Willoughby
  • Publication number: 20140349328
    Abstract: The current invention describes in vivo and vitro (cultured) sampling technologies that allow direct temporal and spatial sampling from living ecosystems such as those associated with marine ecology. The optional use of parallel sampling methods, observatory design, provides for the ability to measure the response of individual organisms to a variety of both biotic and abiotic stresses. Sampling in small volumes and close proximity to living organisms has allowed direct measurement of various invertebrate and other aquatic species in marine ecosystems. These sampling techniques are intended to apply to any liquid based ecosystem in an attempt to minimize sampling as a dependent variable in measuring the chemical and biological behavior of the ecosystem. If is intended that this sampling technology be used to directly measure the chemical behavior of a wide variety of organisms; including, plants, animals, and micro-organisms (e.g. algae, plankton).
    Type: Application
    Filed: May 24, 2013
    Publication date: November 27, 2014
    Applicant: BiOMICom Incorporated
    Inventors: James D. Buchner, Ross C. Willoughby
  • Patent number: 4977785
    Abstract: Methods and apparatus for introduction of sample from a flowing stream into mass spectrometers or other analyzing apparatus for analytical and process stream analysis of the sample. The apparatus generates an aerosol during the decompression of a gas, liquid or supercritical fluid stream. The aerosol's properties are dependent upon mass flow, pressure, temperature, solubility of sample, and the physical dimensions of the aerosol generating device. Upon aerosol generation, a less volatile sample in the form of condensed particles is separated from the gaseous components by accelerating the aerosol through a nozzle restrictor and utilizing momentum differences between solute particles and carrier gas molecules to obtain high solute enrichments at various particles or gas-phase detectors. The device functions primarily as an interface between a supercritical fluid chromatograph and the mass spectrometer.
    Type: Grant
    Filed: February 19, 1988
    Date of Patent: December 18, 1990
    Assignee: Extrel Corporation
    Inventors: Ross C. Willoughby, James D. Buchner